IEM head

Department

Department of Developmental Biology

Head

Ondrej Machon, PhD

Website

http://www.iem.cas.cz/en/research/departments/department-of-developmental-biology/

Project title

Molecular interactions of nerve-associated cells with dermal placodes

Supervisor

Ondrej Machon, PhD

Project description

The project will study the interactions of neural crest-derived cranial nerves with epithelial structures, such as developing teeth, hair or salivary glands. We aim to reveal signals from cranial nerves and nerve-associated cells that initiate the formation of epithelial placodes corresponding to the mentioned organs. The experiments are carried out in transgenic mouse models based on tissue-specific gene inactivation in the neural crest. All required mouse strains are already available in our lab and preliminary tests have been initiated.

Candidate profile

M.Sc. (Mgr.) degree or equivalent in molecular/cellular biology or biochemistry; strong interest in developmental and molecular biology

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