Institute of Experimental Medicine of the CAS

Biomedical research towards effective diagnosis and treatment

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Research

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News

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Autumn transformation in the colours of science

Other Published on 06. 11. 2025 Reading time: 1 minute

The BIOCEV Board announces a selection procedure for the position of Scientific Director

Other Published on 30. 10. 2025 Reading time: 1 minute

BIOCEV DAYS 2025: New directions in regenerative medicine and biomedical research

ConferenceProfessional Events Published on 22. 10. 2025 Reading time: 1 minute

A new perspective on the relationship between the nervous system and pancreatic cancer

PublicationResearch Published on 13. 10. 2025 Reading time: 2 minutes

Jan Malínský appointed new director of the IEM CAS

Other Published on 03. 10. 2025 Reading time: 3 minutes

Open science forms the future of research: Arzuv Čaryjeva represented the IEM CAS at the Open Science Fair 2025 conference in Geneva

ConferenceProfessional Events Published on 03. 10. 2025 Reading time: 2 minuty
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Events

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12. 11. 2025 - 14. 11. 2025

Introduction to Programming for Image Processing

CourseCzech-BioimagingMicroscopy

25. 11. 2025

μLectures: Noise in microscopy images

Czech-BioimagingMicroscopyμLectures

04. 12. 2025

Institutional Seminar Series 12/2025

Professional EventsSeminar
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About Us

We are a renowned centre of basic biomedical research in the Czech Republic and worldwide. Our projects are focused on biomedical challenges, such as finding effective diagnostic markers and treatment of serious diseases associated with ageing of the human population (neurodegeneration, trauma, ischemia, musculoskeletal disorders, cancer and degenerative changes in vision and hearing). We also seriously consider the impact of environmental pollution on human health.

  • We are a proud holder of the “HR Excellence in Research” and “Ethnic Friendly Employer” awards.
  • We are a member of the Euro-BioImaging, Czech-BioImaging, EATRIS, and NanoEnviCz infrastructures.
More information
Annual Brochure 2023 – 2024 (pdf, 28616 kB)
  • 1975 Established
  • 219 Employees
  • 46 Projects
  • 86 Publications (2024)

Research Departments and Centres

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Department of Molecular Biology of Cancer

Research Department

Head of the Department

Veronika Vymetálková

Centre for Reconstructive Neuroscience

Research Centre

Head of the Research Centre

James Fawcett

Department of Functional Organisation of Biomembranes

Research Department

Head of the Department

Jan Malínský

Department of Cell Nucleus Plasticity

Research Department

Head of the Department

Helena Fulková

Department of Developmental Biology

Research Department

Head of the Department

Ondřej Machoň

Department of Toxicology and Molecular Epidemiology

Research Department

Head of the Department

Pavel Rössner

Department of Neurochemistry

Research Department

Head of the Department

Martin Horák

Department of Neuroregeneration

Research Department

Head of the Department

Pavla Jendelová

Department of Auditory Neuroscience

Research department

Head of the Department

Rostislav Tureček

Department of Cellular Neurophysiology

Research Department

Head of the Department

Miroslava Anděrová

Department of Tissue Engineering

Research Department

Head of the Department

Eva Filová

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Latest Publications

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Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses

 Department of Neuroregeneration AutořiRen L.Liu C.Çifcibaşı K.Ballmann M.Rammes G.Mota Reyes C.Tokalov S.Klingl A.Grünert J.Goyal K....Romanyuk N.Giesert F.Saur D.Rad R.Schmid R. M.Algül H.Krüger A.Friess H.Ceyhan G. O.Istvanffy R.Demir İ. E. Published on 2025 Metadata Cancer Cell . 2025 Sep 25:S1535-6108(25)00395-2. doi: 10.1016/j.ccell.2025.09.003. Online ahead of print.

DNA damage in oral mucosal epithelial cells cultured in complex and xenobiotic-free media: a comparison study

 Department of Molecular Biology of Cancer AutořiCabral J. V.Vodenková S.Tomášová K.Vodickova L.El Yamani N.Rundén Pran E.Dusinska M.Safanda A.Jirsova K. Published on 2025 Metadata Mutagenesis . 2025 Aug 29;40(3):526-532. doi: 10.1093/mutage/geaf008.

Mechanisms underlying low mutation rates in mammalian oocytes and preimplantation embryos

 Department of Cell Nucleus Plasticity AutořiDudko N.Dobrucki J. W.Fulka H. Published on 2025 Metadata Nucleic Acids Res . 2025 Aug 11;53(15):gkaf760. doi: 10.1093/nar/gkaf760.

Novel tacrine-based multi-target directed Ligands: Enhancing cholinesterase inhibition, NMDA receptor antagonism, and CNS bioavailability for Alzheimer's disease treatment

 Department of Neurochemistry AutořiSvobodova B.Moravcova Z.Misiachna A.Novakova G.Marek A.Finger V.Odvarkova J.Pejchal J.Zdarova Karasova J.Netolický J.Ladislav M.Hrabinova M.Sorf A.Muckova L.Fikejzlova L.Benkova M.Novak M.Prchal L.Capek J.Handl J.Rousar T.Greber K. E.Ciura K.Horák M.Soukup O.Korabecny J. Published on 2025 Metadata Eur J Med Chem . 2025 Aug 5:292:117678. doi: 10.1016/j.ejmech.2025.117678. Epub 2025 Apr 22.

Enhanced Response of ZnO Nanorod-Based Flexible MEAs for Recording Ischemia-Induced Neural Activity in Acute Brain Slices

 Department of Cellular Neurophysiology AutořiDel Río De Vicente J. I.Marchetti V.Lucarini I.Palmieri E.Polese D.Montaina L.Maita F.Kriška J.Turečková J.Anděrová M.Maiolo L. Published on 2025 Metadata Nanomaterials (Basel) . 2025 Jul 30;15(15):1173. doi: 10.3390/nano15151173.

Protamine sequence determines species-specific nuclear shape and histone retention

 Department of Cell Nucleus Plasticity AutořiCzernik M.Palazzese L.Winiarczyk D.Iuso D.Khochbin S.Fulka J.Fulka H.Fulka H.Villafranca R.Rielo J. A.Sanchez-Rodriguez A.Latorre N.Agudo-Rios C.Roldan E. R. S.Teves M. E.Loi P. Published on 2025 Metadata iScience . 2025 Jul 12;28(8):113102. doi: 10.1016/j.isci.2025.113102. eCollection 2025 Aug 15.

Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer

 Department of Molecular Biology of Cancer AutořiSimoes A. R.Carlés González S.Lopez-Doldan M. C.Duran G.Fernández-Montes A.Fernandez M. P.Salgado Fernandez M.Garcia Mata J.Paez D.Riera P.Guino E.Lopez-Fernandez L.Garcia de Santiago B.López Aspiroz E.Rojas A.Castells A.Castellvi-Bel S.Ruiz Ponte C.Vymetálková V.Carracedo A.Fernandez-Rozadilla C. Published on 2025 Metadata Br J Pharmacol . 2025 Jul 7. doi: 10.1111/bph.70051. Online ahead of print.

Biomimetic Tumour Model Systems for Pancreatic Ductal Adenocarcinoma in Relation to Photodynamic Therapy

 Department of Molecular Biology of Cancer AutořiSmith O. M.Lintern N.Tian J.Mesquita B. M.Oliveira S.Vymetálková V.Prakash J.Smith A. M.Jayne D. G.Heger M.Khaled Y. S.Photodynamic Therapy Study Group Published on 2025 Metadata Int J Mol Sci . 2025 Jul 2;26(13):6388. doi: 10.3390/ijms26136388.

Distinct Regulation of Early Trafficking of the NMDA Receptors by the Ligand-Binding Domains of the GluN1 and GluN2A Subunits

 Department of Neurochemistry AutořiNetolický J.Baráčková P.Misiachna A.Kolcheva M.Řeháková K.Hemelíková K.Kortus S.Langore E.Doderović J.Ladislav M.Korabecny J.Otyepka M.Srejber M.Horák M. Published on 2025 Metadata J Neurosci . 2025 Jun 25;45(26):e0226242025. doi: 10.1523/JNEUROSCI.0226-24.2025.
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