Institute of Experimental Medicine of the CAS

Biomedical research towards effective diagnosis and treatment

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Research

Study & Careers


News

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The Frontiers in Oncology journal has published an editorial by scientists of the IEM CAS

PublicationResearch Published on 21. 11. 2023 Reading time: 1 minute

The poster by Andrea Rössnerová was awarded the special committee award "Honorable Mention"

Award Published on 20. 11. 2023 Reading time: 1 minute

Final results of the NEURORECON project: Gene therapy takes spinal cord injury treatment a step further, and helps restore axon growth

Press ReleaseResearch Published on 31. 10. 2023 Reading time: 4 minutes
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Events

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07. 12. 2023

Institutional Seminar Series 12/2023

Institutional SeminarProfessional Events

04. 01. 2024

Institutional Seminar Series 01/2024

Professional EventsSeminar

18. 01. 2024

Institutional Seminar Series (alternative date from 10/2023)

Institutional SeminarProfessional Events

01. 02. 2024

Institutional Seminar Series 02/2024

Professional EventsSeminar

07. 03. 2024

Institutional Seminar Series 03/2024

Professional EventsSeminar
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About Us

We are a renowned centre of basic biomedical research in the Czech Republic and worldwide. Our projects are focused on biomedical challenges, such as finding effective diagnostic markers and treatment of serious diseases associated with ageing of the human population (neurodegeneration, trauma, ischemia, musculoskeletal disorders, cancer and degenerative changes in vision and hearing). We also seriously consider the impact of environmental pollution on human health.

  • We are a proud holder of the “HR Excellence in Research” and “Ethnic Friendly Employer” awards.
  • We are a member of the Czech-Bioimaging, EATRIS, and NanoEnviCz infrastructures.
More information
Annual Brochure 2021-2022 (pdf, 46372 kB)
  • 1975 Established
  • 202 Employees
  • 74 Projects
  • 90 Publications (2022)

Research Departments and Centres

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Department of Nanotoxicology and Molecular Epidemiology

Research Department

Head of the Department

Pavel Rössner

Department of Developmental Biology

Research Department

Head of the Department

Ondřej Machoň

Department of Neuroregeneration

Research Department

Head of the Department

Pavla Jendelová

Department of Neurochemistry

Research Department

Head of the Department

Martin Horák

Department of Auditory Neuroscience

Research department

Head of the Department

Rostislav Tureček

Department of Tissue Engineering

Research Department

Head of the Department

Eva Filová

Centre for Reconstructive Neuroscience

Research Centre

Head of the Research Centre

James Fawcett

Department of the Molecular Biology of Cancer

Research Department

Head of the Department

Pavel Vodička

Department of Cell Nucleus Plasticity

Research Department

Head of the Department

Helena Fulková

Department of Genetic Toxicology and Epigenetics

Research Department

Head of the Department

Jan Topinka

Department of Functional Organisation of Biomembranes

Research Department

Head of the Department

Jan Malínský

Department of Cellular Neurophysiology

Research Department

Head of the Department

Miroslava Anděrová

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Latest Publications

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Low oral dose of 4-methylumbelliferone reduces glial scar but is insufficient to induce functional recovery after spinal cord injury

 DepartmentCentre for Reconstructive Neuroscience Department of Neuroregeneration AutořiŠtěpánková K.Chudíčková M.Šimková Z.Varea N.Kubinová Š.Urdzíková-Machová L.Jendelová P.Kwok J.C.F. Published on 2023 Metadata Sci Rep. 2023 Nov 6;13(1):19183. doi: 10.1038/s41598-023-46539-5.

Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations

 DepartmentDepartment of the Molecular Biology of Cancer AutořiThomas M.Su Y-R.Rosenthal E. A.Sakoda L. C.Schmit S. L.Timofeeva M. N.Chen Z.Fernandez-Rozadilla C.Law P. J.Murphy N.Carreras-Torres R.Diez-Obrero V.van Duijnhoven F. J. B.Jiang S.Shin A.Wolk A.Phipps A. I.Burnett-Hartman A.Gsur A.Chan A. T.Zauber A. G.Wu A. H.Lindblom A.Um C. Y.Tangen C. M.Gignoux C.Newton C.Haiman C. A.Qu C.Bishop D. T.Buchanan D. D.Crosslin D. R.Conti D. V.Kim D-H.Hauser E.White E.Siegel E.Schumacher F. R.Rennert G.Giles G. G.Hampel H.Brenner H.Oze I.Oh J. H.Lee J. K.Schneider J. L.Chang-Claude J.Kim J.Huyghe J. R.Zheng J.Hampe J.Greenson J.Hopper J. L.Palmer J. R.Visvanathan K.Matsuo K.Matsuda K.Jung K. J.Li L.Le Marchand L.Vodičková L.Bujanda L.Gunter M. J.Matejcic M.Jenkins M. A.Slattery M. L.D'Amato M.Wang M.Hoffmeister M.Woods M. O.Kim M.Song M.Iwasaki M.Du M.Udaltsova N.Sawada N.Vodička P.Campbell P. T.Newcomb P. A.Cai Q.Pearlman R.Pai R. K.Schoen R. E.Steinfelder R. S.Haile R. W.Vandenputtelaar R.Prentice R. L.Küry S.Castellví-Bel S.Tsugane S.Berndt S. I.Lee S. C.Brezina S.Weinstein S. J.Chanock S. J.Jee S. H.Kweon S-S.Vadaparampil S.Harrison T. A.Yamaji T.Keku T. O.Vymetálková V.Arndt V.Jia W-H.Shu X-O.Lin Y.Ahn Y-O.Stadler Z. K.Van Guelpen B.Ulrich C. M.Platz E. A.Potter J. D.Li C. I.Meester R.Moreno V.Figueiredo J. C.Casey G.Lansdorp Vogelaar I.Dunlop M. G.Gruber S. B.Hayes R. B.Pharoah P. D.Houlston R. S.Jarvik G. P.Tomlinson I. P.Zheng W.Corley D. A.Peters U.Hsu L. Published on 2023 Metadata Nat Commun. 2023 Oct 2;14(1):6147. doi: 10.1038/s41467-023-41819-0.

Astrocyte-like subpopulation of NG2 glia in the adult mouse cortex exhibits characteristics of neural progenitor cells

 DepartmentDepartment of Cellular Neurophysiology AutořiJaneckova L.Knotek T.Kriška J.Heřmanová Z.Kirdajová D.Kubovciak J.Berkova L.Turečková J.Garcia S. C.Galuskova K.Kolar M.Anděrová M.Korinek V. Published on 2023 Metadata Glia . 2023 Sep 29. doi: 10.1002/glia.24471. Online ahead of print.

Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment

 DepartmentDepartment of Genetic Toxicology and Epigenetics AutořiMussalo L.Avesani S.Shahbaz M. A.Závodná T.Saveleva L.Järvinen A.Lampinen R.Belaya I.Krejčík Z.Ivanova M.Hakkarainen H.Kalapudas J.Penttilä E.Löppönen H.Koivisto A. M.Malm T.Topinka J.Giugno R.Aakko-Saksa P.Chew S.Rönkkö T.Jalava P.Kanninen K. M. Published on 2023 Metadata Sci Total Environ . 2023 Sep 13;905:167038. doi: 10.1016/j.scitotenv.2023.167038. Online ahead of print.

Lactose-Functionalized Carbosilane Glycodendrimers Are Highly Potent Multivalent Ligands for Galectin-9 Binding: Increased Glycan Affinity to Galectins Correlates with Aggregation Behavior

 DepartmentDepartment of Genetic Toxicology and Epigenetics AutořiMüllerová M.Hovorková M.Závodná T.Červenková Štastná L.Krupková A.Hamala V.Nováková K.Topinka J.Bojarová P.Strašák T. Published on 2023 Metadata Biomacromolecules . 2023 Sep 8. doi: 10.1021/acs.biomac.3c00426. Online ahead of print.

Characterization of RACK1-depleted mammalian cells by a palette of microscopy approaches reveals defects in cell cycle progression and polarity establishment

 DepartmentDepartment of Cellular Neurophysiology AutořiChvalová V.Venkadasubramanian V.Klimová Z.Vojtová J.Benada O.Vaňátko O.Vomastek T.Grousl T. Published on 2023 Metadata Exp Cell Res. 2023 Sep 1;430(1):113695. doi: 10.1016/j.yexcr.2023.113695. Epub 2023 Jun 30.

Autologous Mesenchymal Stromal Cells Immobilized in Plasma-Based Hydrogel for the Repair of Articular Cartilage Defects in a Large Animal Model

 DepartmentDepartment of Neuroregeneration AutořiBerounský K.Vacková I.Vištejnová L.Malečková A.Havránková J.Klein P.Kolinko Y.Petrenko Y.Pražák Š.Hanák F.Přidal J.Havlas V. Published on 2023 Metadata Physiol Res. 2023 Aug 31;72(4):485-495. doi: 10.33549/physiolres.935098.

Progress in Stem Cells-Based Replacement Therapy for Retinal Pigment Epithelium: In Vitro Differentiation to In Vivo Delivery

 DepartmentDepartment of Neuroregeneration AutořiGupta S.Lytvynchuk L.Ardan T.Studenovska H.Sharma R.Faura G.Eide L.Verma R. S.Znaor L.Erceg S.Stieger K.Motlik J.Petrovski G.Bharti K. Published on 2023 Metadata Stem Cells Transl Med. 2023 Aug 16;12(8):536-552. doi: 10.1093/stcltm/szad039.

A genetic locus within the FMN1/GREM1 gene region interacts with body mass index in colorectal cancer risk

 DepartmentDepartment of the Molecular Biology of Cancer AutořiAglago E. K.Kim A. E.Lin Y.Qu C.Evangelou M.Ren Y.Morrison J.Albanes D.Arndt V.Barry E. L.Baurley J. W.Berndt S. I.Bien S. A.Bishop D. T.Bouras E.Brenner H.Buchanan D. D.Budiarto A.Carreras-Torres R.Casey G.Cenggoro T. W.Chan A. T.Chang-Claude J.Chen X.Conti D. V.Devall M.Díez-Obrero V.Dimou N.Drew D.Figueiredo J. C.Gallinger S.Giles G. G.Gruber S. B.Gsur A.Gunter M. J.Hampel H.Harlid S.Hidaka A.Harrison T. A.Hoffmeister M.Huyghe J. R.Jenkins M. A.Jordahl K.Joshi A. D.Kawaguchi E. S.Keku T. O.Kundaje A.Larsson S. C.Le Marchand L.Lewinger J. P.Li L.Lynch B. M.Mahesworo B.Mandic M.Obón-Santacana M.Moreno V.Murphy N.Nan H.Nassir R.Newcomb P. A.Ogino S.Ose J.Pai R. K.Palmer J. R.Papadimitriou N.Pardamean B.Peoples A. R.Platz E. A.Potter J. D.Prentice R. L.Rennert G.Ruiz-Narvaez E.Sakoda L. C.Scacheri P. C.Schmit S. L.Schoen R. E.Shcherbina A.Slattery M. L.Stern M. C.Su Y. R.Tangen C. M.Thibodeau S. N.Thomas D. C.Tian Y.Ulrich C. M.van Duijnhoven F. J. B.Van Guelpen B.Visvanathan K.Vodička P.Wang J.White E.Wolk A.Woods M. O.Wu A. H.Zemlianskaia N.Hsu L.Gauderman W. J.Peters U.Tsilidis K. K.Campbell P. T. Published on 2023 Metadata Cancer Res . 2023 May 30;CAN-22-3713. doi: 10.1158/0008-5472.CAN-22-3713. Online ahead of print.
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