Institute of Experimental Medicine of the CAS

Biomedical research towards effective diagnosis and treatment

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News

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The Academic Council of the CAS has elected the members of the Academy and Science Councils. Among them are Miroslava Anděrová, Director of the IEM CAS, and neuroscientist Pavla Jendelová

Award Published on 18. 03. 2025 Reading time: 2 minutes

Interview with toxicologists Jan Topinka and Kateřina Hoňková on Czech Television

InterviewTV Report Published on 16. 03. 2025 Reading time: 3 minutes

Scientists of the IEM CAS successfully defended the highest scientific degree – Research Professor

OtherResearch Published on 13. 03. 2025 Čtení na 5 minut

Téma magazine: Interview with neuroscientist Oliver Profant

ArticleInterview Published on 28. 02. 2025 Reading time: 1 minute

13th AACR-JCA Conference 2025: Scientists of the IEM CAS at the prestigious international conference

ConferenceProfessional Events Published on 20. 02. 2025 Reading time: 1 minute

The International Day of Women and Girls in Science – 154 reasons to celebrate

Popularisation of Science Published on 11. 02. 2025 Reading time: 1 minute
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Events

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24. 03. 2025

μLectures: Fluorophores

Czech-BioimagingMicroscopyμLectures

03. 04. 2025

Institutional Seminar Series 4/2025

Professional EventsSeminar

29. 05. 2025 - 30. 05. 2025

Advanced 3D image visualization and quantification

CourseCzech-BioimagingMicroscopy

02. 06. 2025 - 05. 06. 2025

53rd European Environment Mutagenesis and Genomics Society Meeting

ConferenceProfessional Events

08. 09. 2025 - 12. 09. 2025

Advanced Course on Preclinical Imaging

CourseCzech-BioimagingMicroscopy

12. 11. 2025 - 14. 11. 2025

Introduction to Programming for Image Processing

CourseCzech-BioimagingMicroscopy
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About Us

We are a renowned centre of basic biomedical research in the Czech Republic and worldwide. Our projects are focused on biomedical challenges, such as finding effective diagnostic markers and treatment of serious diseases associated with ageing of the human population (neurodegeneration, trauma, ischemia, musculoskeletal disorders, cancer and degenerative changes in vision and hearing). We also seriously consider the impact of environmental pollution on human health.

  • We are a proud holder of the “HR Excellence in Research” and “Ethnic Friendly Employer” awards.
  • We are a member of the Euro-BioImaging, Czech-BioImaging, EATRIS, and NanoEnviCz infrastructures.
More information
Annual Brochure 2021-2022 (pdf, 46372 kB)
  • 1975 Established
  • 219 Employees
  • 46 Projects
  • 86 Publications (2024)

Research Departments and Centres

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Department of Molecular Biology of Cancer

Research Department

Head of the Department

Veronika Vymetálková

Department of Functional Organisation of Biomembranes

Research Department

Head of the Department

Jan Malínský

Department of Cellular Neurophysiology

Research Department

Head of the Department

Miroslava Anděrová

Department of Neurochemistry

Research Department

Head of the Department

Martin Horák

Department of Cell Nucleus Plasticity

Research Department

Head of the Department

Helena Fulková

Department of Tissue Engineering

Research Department

Head of the Department

Eva Filová

Department of Neuroregeneration

Research Department

Head of the Department

Pavla Jendelová

Department of Auditory Neuroscience

Research department

Head of the Department

Rostislav Tureček

Centre for Reconstructive Neuroscience

Research Centre

Head of the Research Centre

James Fawcett

Department of Developmental Biology

Research Department

Head of the Department

Ondřej Machoň

Department of Toxicology and Molecular Epidemiology

Research Department

Head of the Department

Pavel Rössner

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Latest Publications

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Hyperactive delta isoform of PI3 kinase enables long-distance regeneration of adult rat corticospinal tract

 Department of Neuroregeneration Department of Auditory Neuroscience AutořiKárová K.Polčanová Z.Knight L.Suchánková S.Nieuwenhuis B.Holota R.Herynek V.Urdzíková-Machová L.Tureček R.Kwok J.C.F.Herik J. vdVerhaagen J.Eva R.Fawcett J.Jendelová P. Published on 2025 Metadata Mol Ther. 2025 Feb 5;33(2):752-770. doi: 10.1016/j.ymthe.2024.12.040. Epub 2025 Jan 1.

Binding of HCN channels to GABAB receptors in dopamine neurons of the VTA limits synaptic inhibition and prevents the development of anxiety

 Department of Auditory Neuroscience AutořiPérez-Garci E.Pysanenko K.Rizzi G.Studer F.Ulrich D.Fritzius T.Früh S.Porcu A.Besseyrias V.Melichar A.Gassmann M.Barkat T. R.Tureček R.Tan K. R.Bettler B. Published on 2025 Metadata Neurobiol Dis. 2025 Feb 4:206:106831. doi: 10.1016/j.nbd.2025.106831. Online ahead of print.

Polymorphisms within autophagy-related genes as susceptibility biomarkers for pancreatic cancer: A meta-analysis of three large European cohorts and functional characterization

 Department of Molecular Biology of Cancer AutořiGálvez-Montosa F.Peduzzi G.Sanchez-Maldonado J. M.Horst R. T.Cabrera-Serrano A. J.Gentiluomo M.Macauda A.Luque N.Ünal P.García-Verdejo F. J.Li Y.López J. A. L.Stein A.Bueno-de-Mesquita H. B.Arcidiacono P. G....Vodičková L....Dohan O.Tacelli M.Greenhalf W.Gazouli M.Neoptolemos J. P.Cavestro G. M.Boggi U.Latiano A.Hegyi P.Ginocchi L.Netea M. G.Sánchez-Rovira P.Canzian F.Campa D.Sainz J. Published on 2025 Metadata Int J Cancer. 2025 Jan 15;156(2):339-352. doi: 10.1002/ijc.35196. Epub 2024 Sep 25.

Portable emissions toxicity system: Evaluating the toxicity of emissions or polluted air by exposure of cell cultures at air-liquid interface in a compact field-deployable setup

 Department of Toxicology and Molecular Epidemiology AutořiVojtíšek M.Dittrich L.Pechout M.Červená T.Vimrová A.Sikorová J.Závodná T.Ondracek J.Aakko-Saksa P.Topinka J.Rössner P. Published on 2025 Metadata Sci Total Environ. 2025 Jan 10:959:178010. doi: 10.1016/j.scitotenv.2024.178010. Epub 2024 Dec 21.

The Influence of Asymmetric Hearing Loss on Peripheral and Central Auditory Processing Abilities in Patients With Vestibular Schwannoma

 Department of Auditory Neuroscience AutořiSvobodova V.Profant O.Syka J.Tóthová D.Bureš Z. Published on 2025 Metadata Ear Hear. 2025 Jan-Feb;46(1):60-70. doi: 10.1097/AUD.0000000000001555. Epub 2024 Jul 15.

Real-world outdoor air exposure effects in a model of the human airway epithelium - A comparison of healthy and asthmatic individuals using a mobile laboratory setting

 Department of Toxicology and Molecular Epidemiology AutořiRössner P.Líbalová H.Červená T.Šíma M.Šímová Z.Vrbová K.Ambrož A.Nováková Z.Elzeinová F.Vimrová A.Dittrich L.Vojtisek M.Pechout M.Vojtisek-Lom M. Published on 2025 Metadata Ecotoxicol Environ Saf. 2025 Jan 1:289:117495. doi: 10.1016/j.ecoenv.2024.117495. Epub 2024 Dec 7.

Characterization of additive gene-environment interactions for colorectal cancer risk

 Department of Molecular Biology of Cancer AutořiThomas C.E.Lin Y.Kim M.Kawaguchi E.S.Qu C.Um C.Y.Lynch B.M.Van Guelpen B.Tsilidis K.Carreras-Torres R.van Duijnhoven F.J.B.Sakoda L.C.Campbell P.T.Tian Y.Chang-Claude J.Bézieau S.Budiarto A.Palmer J.R.Newcomb P.A.Casey G.Le Marchand L.Giannakis M.Li C.I.Gsur A.Newton C.Obón-Santacana M.Moreno V.Vodička P.Brenner H.Hoffmeister M.Pellatt A.J.Schoen R.E.Dimou N.Murphy N.Gunter M.J.Castellví-Bel S.Figueiredo J.C.Chan A.T.Song M.Li L.Bishop D.T.Gruber S.B.Baurley J.W.Bien S.A.Conti D.V.Huyghe J.R.Kundaje A.Su Y.-R.Wang J.Keku T.O.Woods M.O.Berndt S.I.Chanock S.J.Tangen C.M.Wolk A.Burnett-Hartman A.Wu A.H.White E.Devall M.A.Díez-Obrero V.Drew D.A.Giovannucci E.Hidaka A.Kim A.E.Lewinger J.P.Morrison J.Ose J.Papadimitriou N.Pardamean B.Peoples A.R.Ruiz-Narvaez E.A.Shcherbina A.Stern M.C.Chen X.Thomas D.C.Platz E.A.Gauderman W.J.Peters U.Hsu L. Published on 2025 Metadata Epidemiology. 2025 Jan 1;36(1):126-138. doi: 10.1097/EDE.0000000000001795. Epub 2024 Sep 24.

Transcriptomic and epigenomic profiling reveals alteredresponses to diesel emissions in Alzheimer’s disease both invitro and in population-based data

 Department of Toxicology and Molecular Epidemiology AutořiSaveleva L.Červená T.Mengoni C.Šíma M.Krejčík Z.Vrbová K.Sikorová J.Mussalo L.de Crom T. O. E.Šímová Z.Ivanova M.Shahbaz M. A.Penttilä E.Löppönen H.Koivisto A. M.Ikram M. A.Jalava P. I.Malm T.Chew S.Vojtíšek M.Topinka J.Giugno R.Rössner P.Kanninen K. M. Published on 2024 Metadata Alzheimers Dement . 2024 Dec 24. doi: https://doi.org/10.1002/alz.14347.

Comparative Study of Functionalized Carbosilane Dendrimers for siRNA Delivery: Synthesis, Cytotoxicity, and Biophysical Properties

 Department of Toxicology and Molecular Epidemiology AutořiMüllerová M.Tarach P.Strašák T.Cuřínová P.Petrickovic R.Závodná T.Topinka J.Janaszewska A.Klajnert-Maculewicz B.Červenková Št'astná L. Published on 2024 Metadata ACS Omega. 2024 Dec 20;10(1):1047-1060. doi: 10.1021/acsomega.4c08314. eCollection 2025 Jan 14.
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