Institute of Experimental Medicine of the CAS

Biomedical research towards effective diagnosis and treatment

About Us

Research

Study & Careers


News

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Job opening for a postdoctoral position – Department of Genome Biology

CareerOpen Position Published on 14. 01. 2026 Reading time: 1 minute

Czech research on the cover of Hearing Research journal: A new co-authored study by scientists from the IEM CAS reveals early structural and functional changes in Alzheimer's disease

PublicationResearch Published on 13. 01. 2026 Reading time: 2 minutes

From the past to the future: The IEM CAS celebrated its 50th anniversary

AnniversaryConference Published on 19. 12. 2025 Reading time: 3 minutes

The President of the Czech Republic has appointed new professors, including Jan Malínský

Award Published on 17. 12. 2025 Reading time: 1 minute

Kristýna Kárová: The spinal cord is a fascinating element of the central nervous system

ArticleInterview Published on 16. 12. 2025 Reading time: 1 minute

World first for Czech science: The IEM CAS research team has demonstrated the feasibility of reversing oocyte ageing

PublicationResearch Published on 03. 12. 2025 Reading time: 5 minutes
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Events

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27. 01. 2026

μLectures: Noise in microscopy images

Czech-BioimagingMicroscopyμLectures

05. 02. 2026

Institutional Seminar Series 2/2026 (Double Seminar)

Professional EventsSeminar

07. 05. 2026

Institutional Seminar Series 5/2026

Professional EventsSeminar

28. 05. 2026 - 29. 05. 2026

Advanced 3D image visualization and quantification

CourseCzech-BioimagingMicroscopy

04. 06. 2026

Institutional Seminar Series 6/2026

Professional EventsSeminar

02. 12. 2026 - 04. 12. 2026

Introduction to programming for image processing

CourseCzech-BioimagingMicroscopy
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About Us

We are a renowned centre of basic biomedical research in the Czech Republic and worldwide. Our projects are focused on biomedical challenges, such as finding effective diagnostic markers and treatment of serious diseases associated with ageing of the human population (neurodegeneration, trauma, ischemia, musculoskeletal disorders, cancer and degenerative changes in vision and hearing). We also seriously consider the impact of environmental pollution on human health.

  • We are a proud holder of the “HR Excellence in Research” and “Ethnic Friendly Employer” awards.
  • We are a member of the Euro-BioImaging, Czech-BioImaging, EATRIS, and NanoEnviCz infrastructures.
More information
Annual Brochure 2023 – 2024 (pdf, 28616 kB)
  • 1975 Established
  • 220 Employees
  • 31 Projects
  • 79 Publications (2025)

Research Departments and Centres

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Department of Neuroregeneration

Research Department

Head of the Department

Pavla Jendelová

Department of Developmental Biology

Research Department

Head of the Department

Ondřej Machoň

Department of Functional Organisation of Biomembranes

Research Department

Head of the Department

Jan Malínský

Department of Cell Nucleus Plasticity

Research Department

Head of the Department

Helena Fulková

Department of Toxicology and Molecular Epidemiology

Research Department

Head of the Department

Pavel Rössner

Department of Genome Biology

Research department

Head of Department

Martin Andrš

Department of Molecular Biology of Cancer

Research Department

Head of the Department

Veronika Vymetálková

Department of Neurochemistry

Research Department

Head of the Department

Martin Horák

Department of Auditory Neuroscience

Research department

Head of the Department

Rostislav Tureček

Department of Tissue Engineering

Research Department

Head of the Department

Eva Filová

Department of Cellular Neurophysiology

Research Department

Head of the Department

Miroslava Anděrová

Centre for Reconstructive Neuroscience

Research Centre

Head of the Research Centre

James Fawcett

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Latest Publications

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Impaired prepulse inhibition in APP/PS1 mice is accompanied by substantial morphological changes in neurons of the central auditory system and hippocampus

 Department of Auditory Neuroscience AutořiSvobodová Burianová J.Černotová D.Klausová T.Profant O.Fuksa J.Syka J.Svoboda J. Published on 2026 Metadata Hear Res . 2026 Jan:469:109484. doi: 10.1016/j.heares.2025.109484. Epub 2025 Nov 20.

Oocyte Age-Dependent DNA Damage Can Be Reverted by the DNA Repair Competent Karyoplasm of Young Oocytes

 Department of Cell Nucleus Plasticity AutořiDudko N.Ilčíková T.Novotna N.Czernik M.Loi P.Fulka J. Jr.Bhattacharjee P.Santoro R.Fulka H. Published on 2025 Metadata Aging Cell . 2025 Nov 15:e70300. doi: 10.1111/acel.70300. Online ahead of print.

Mutations in GFAP Alter Early Lineage Commitment of Organoids

 Department of Cellular Neurophysiology AutořiDykstra W.Matusova Z.Battaglia R. A.Abaffy P.Goya-Iglesias N.Pérez-Sala D.Ahlenius H.Kubista M.Pasterkamp R. J.Li L.Chao J.Shi Y.Valihrach L.Pekny M.Hol E. M. Published on 2025 Metadata Glia . 2025 Nov;73(11):2167-2188. doi: 10.1002/glia.70049. Epub 2025 Jul 30.

Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses

 Department of Neuroregeneration AutořiRen L.Liu C.Çifcibaşı K.Ballmann M.Rammes G.Mota Reyes C.Tokalov S.Klingl A.Grünert J.Goyal K....Romanyuk N.Giesert F.Saur D.Rad R.Schmid R. M.Algül H.Krüger A.Friess H.Ceyhan G. O.Istvanffy R.Demir İ. E. Published on 2025 Metadata Cancer Cell . 2025 Sep 25:S1535-6108(25)00395-2. doi: 10.1016/j.ccell.2025.09.003. Online ahead of print.

DNA damage in oral mucosal epithelial cells cultured in complex and xenobiotic-free media: a comparison study

 Department of Molecular Biology of Cancer AutořiCabral J. V.Vodenková S.Tomášová K.Vodickova L.El Yamani N.Rundén Pran E.Dusinska M.Safanda A.Jirsova K. Published on 2025 Metadata Mutagenesis . 2025 Aug 29;40(3):526-532. doi: 10.1093/mutage/geaf008.

Mechanisms underlying low mutation rates in mammalian oocytes and preimplantation embryos

 Department of Cell Nucleus Plasticity AutořiDudko N.Dobrucki J. W.Fulka H. Published on 2025 Metadata Nucleic Acids Res . 2025 Aug 11;53(15):gkaf760. doi: 10.1093/nar/gkaf760.

Transcriptomic Profiling of Mouse Mesenchymal Stem Cells Exposed to Metal-Based Nanoparticles

 Department of Toxicology and Molecular Epidemiology AutořiŠíma M.Líbalová H.Šímová Z.Echalar B.Palacká K.Červená T.Klema J.Krejčík Z.Holáň V.Rössner P. Published on 2025 Metadata Int J Mol Sci . 2025 Aug 5;26(15):7583. doi: 10.3390/ijms26157583.

Novel tacrine-based multi-target directed Ligands: Enhancing cholinesterase inhibition, NMDA receptor antagonism, and CNS bioavailability for Alzheimer's disease treatment

 Department of Neurochemistry AutořiSvobodova B.Moravcova Z.Misiachna A.Novakova G.Marek A.Finger V.Odvarkova J.Pejchal J.Zdarova Karasova J.Netolický J.Ladislav M.Hrabinova M.Sorf A.Muckova L.Fikejzlova L.Benkova M.Novak M.Prchal L.Capek J.Handl J.Rousar T.Greber K. E.Ciura K.Horák M.Soukup O.Korabecny J. Published on 2025 Metadata Eur J Med Chem . 2025 Aug 5:292:117678. doi: 10.1016/j.ejmech.2025.117678. Epub 2025 Apr 22.

Memantine Administration Enhances Glutamatergic and GABAergic Pathways in the Human Hippocampus of Alzheimer's Disease

Department of Neurochemistry AutořiFabrik I.Kupcik R.Fabrikova D.Chvojkova M.Holubova K.Hakenova K.Horák M.Soukup J.Manethova M.Rusina R.Matej R.Ryska A.Soukup O. Published on 2025 Metadata Proteomics . 2025 Aug;25(15):42-49. doi: 10.1002/pmic.70006. Epub 2025 Jul 9.
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