Department

Centre for Reconstructive Neuroscience

Research Centre

 James Fawcett

Head of the Department

James Fawcett

Publications

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Activated alpha 9 integrin expression enables sensory pathway reconstruction after spinal cord injury

 DepartmentDepartment of Neuroregeneration Department of Auditory Neuroscience AutořiŠtěpánková K.Smejkalová B.Urdzíková-Machová L.Havelíková K.de Winter F.Suchánková S.Verhaagen J.Herynek V.Tureček R.Kwok J. C. F.Fawcett J.Jendelová P. Published on 2025 Metadata Acta Neuropathol Commun . 2025 May 2;13(1):89. doi: 10.1186/s40478-025-01995-0.

Combined strategy of α 9-integrin transduction and AEIDGIEL peptide-functionalized fibrin gel biomaterials to promote mature DRG neurite growth

 DepartmentDepartment of Neuroregeneration AutořiCimpean A.Roll L.Reinhard J.Kwok J. C. F.Faissner A.de Winter F.Fawcett J.Jendelová P. Published on 2025 Metadata Front Cell Neurosci . 2025 Apr 1:19:1568004. doi: 10.3389/fncel.2025.1568004. eCollection 2025.

Hyperactive delta isoform of PI3 kinase enables long-distance regeneration of adult rat corticospinal tract

 DepartmentDepartment of Neuroregeneration Department of Auditory Neuroscience AutořiKárová K.Polčanová Z.Knight L.Suchánková S.Nieuwenhuis B.Holota R.Herynek V.Urdzíková-Machová L.Tureček R.Kwok J. C. F.Herik J. vdVerhaagen J.Eva R.Fawcett J.Jendelová P. Published on 2025 Metadata Mol Ther. 2025 Feb 5;33(2):752-770. doi: 10.1016/j.ymthe.2024.12.040. Epub 2025 Jan 1.

Neuronal maturation and axon regeneration: unfixing circuitry to enable repair

 DepartmentCentre for Reconstructive Neuroscience AutořiHilton B. J.Griffin J. M.Fawcett J.Bradke F. Published on 2024 Metadata Nat Rev Neurosci . 2024 Oct;25(10):649-667. doi: 10.1038/s41583-024-00849-3. Epub 2024 Aug 20.

Inhibition of PHLDA3 expression in human superoxide dismutase 1-mutant amyotrophic lateral sclerosis astrocytes protects against neurotoxicity

 DepartmentDepartment of Neuroregeneration Centre for Reconstructive Neuroscience Department of Cellular Neurophysiology AutořiSzebényi K.Vargová I.Petrova V.Turečková J.Gibbons G. M.Řehořová M.Abdelgawad M.Sándor A.Marekova D.Kwok J. C. F.Jendelová P.Fawcett J.Lakatos A. Published on 2024 Metadata Brain Commun . 2024 Jul 25;6(4):fcae244. doi: 10.1093/braincomms/fcae244. eCollection 2024.

Regenerative capacity of neural tissue scales with changes in tissue mechanics post injury

 DepartmentCentre for Reconstructive Neuroscience AutořiCarnicer-Lombarte A.Barone D. G.Wronowski F.Malliaras G. G.Fawcett J.Franze K. Published on 2023 Metadata Biomaterials . 2023 Dec:303:122393. doi: 10.1016/j.biomaterials.2023.122393. Epub 2023 Nov 9.

Integrin-Driven Axon Regeneration in the Spinal Cord Activates a Distinctive CNS Regeneration Program

 DepartmentCentre for Reconstructive Neuroscience Department of Neuroregeneration AutořiCheah M.Cheng Y.Petrova V.Cimpean A.Jendelová P.Swarup V.Woolf C. J.Geschwind D. H.Fawcett J. Published on 2023 Metadata J Neurosci. 2023 Jun 28;43(26):4775-4794. doi: 10.1523/JNEUROSCI.2076-22.2023. Epub 2023 Jun 5.

Long-Term Cultures of Spinal Cord Interneurons.

 DepartmentCentre for Reconstructive Neuroscience Department of Cellular Neurophysiology Department of Neuroregeneration AutořiVargová I.Kriška J.Kwok J. C. F.Fawcett J.Jendelová P. Published on 2022 Metadata Frontiers in Cellular Neuroscience. 16: 827628

Age-related loss of axonal regeneration is reflected by the level of local translation.

 DepartmentCentre for Reconstructive Neuroscience Autořivan Erp S.van Berkel M.Feenstra E.M.Sahoo P. K.Wagstaff L.J.Twiss J.L.Fawcett J.Eva R.Ffrench-Constant Ch. Published on 2021 Metadata Experimental Neurology. 339: 113594.

Microglia-mediated degradation of perineuronal nets promotes pain.

 DepartmentCentre for Reconstructive Neuroscience AutořiTansley S.Gu N.Guzman A. U.Cai W.Wong C. Lister K.C.Munoz-Pino E.Yousefpour N.Roome R. B.Heal J.Wu N.Castonguay A.Lean G.Muir E. M.Kania A.Prager-Khoutorsky M.Zhang J.Gkogkas Ch.G.Fawcett J.Diatchenko L.Ribeiro-da-Silva A.De Koninck Y.Mogil J.Khoutorsky A. Published on 2022 Metadata Science. 377(6601): 80-86.

Perineuronal nets affect memory and learning after synapse withdrawal.

 DepartmentCentre for Reconstructive Neuroscience AutořiRůžička J.Dalecká M.Šafránková K.Peretti D.Jendelová P.Kwok J. C. F.Fawcett J. Published on 2022 Metadata Translational Psychiatry. 12(1):480.

Proteoglycan Sulphation in the Function of the Mature Central Nervous System.

DepartmentCentre for Reconstructive Neuroscience AutořiFawcett J.Kwok J. C. F. Published on 2022 Metadata Frontiers in Integrative Neuroscience. 16: 895493.

The extracellular matrix and perineuronal nets in memory.

 DepartmentCentre for Reconstructive Neuroscience AutořiFawcett J.Fyhn M.Jendelová P.Kwok J. C. F.Růžička J.Sorg B. Published on 2022 Metadata Molecular Psychiatry. 27(8): 3192-3203.

Oral treatment of 4-methylumbelliferone reduced perineuronal nets and improved recognition memory in mice.

 DepartmentCentre for Reconstructive Neuroscience AutořiDubišová J.Svobodová Burianová J.Svobodová L.Makovický P.Varea N.Cimpean A.Fawcett J.Kwok J. C. F.Kubinová Š. Published on 2022 Metadata Brain Research Bulletin. 181: 144-156.

Prevention of the foreign body response to implantable medical devices by inflammasome inhibition.

 DepartmentCentre for Reconstructive Neuroscience AutořiBarone D.G.Carnicer-Lombarte A.Tourlomousis P.Hamilton R.S.Prater M.Rutz A.L.Dimov I.B.Malliaras G.G.Lacour S.P.Robertson A.A.B.Franze K.Fawcett J.Bryant C.E. Published on 2022 Metadata National Academy of Sciences of the United States of America. 119(12): e2115857119

Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing.

DepartmentCentre for Reconstructive Neuroscience AutořiYang S.Gigout S.Molinaro A.Naito-Matsui Y.Hilton S.Foscarin S.Nieuwenhuis B.Tan Ch.L.Verhaagen J.Pizzorusso T.Saksida L.M.Bussey T.M.Kitagawa H.Kwok J. C. F.Fawcett J. Published on 2021 Metadata Molecular Psychiatry.

Substrate Specificity and Biochemical Characteristics of an Engineered Mammalian Chondroitinase ABC.

 DepartmentCentre for Reconstructive Neuroscience AutořiWarren P.M.Fawcett J.Kwok J. C. F. Published on 2021 Metadata ASC Omega. 6(17): 11223-11230.

Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury.

 DepartmentCentre for Reconstructive Neuroscience AutořiPetrova V.Nieuwenhuis B.Fawcett J.Eva R. Published on 2021 Metadata International Journal of Molecular Sciences. 22(4): 1798.

Transplantation of Neural Precursors Derived from Induced Pluripotent Cells Preserve Perineuronal Nets and Stimulate Neural Plasticity in ALS Rats.

 DepartmentDepartment of Neuroregeneration AutořiForostyak S.Forostyak O.Kwok J. C. F.Romanyuk N.Řehořová M.Kriška J.Dayanithi G.Raha-Chowdhury R.Jendelová P.Anděrová M.Fawcett J.Syková E. Published on 2020 Metadata International Journal of Molecular Sciences. 21(24):9593.

Improving adeno-associated viral (AAV) vector-mediated transgene expression in retinal ganglion cells: comparison of five promoters.

 DepartmentCentre for Reconstructive Neuroscience AutořiNieuwenhuis B.Laperrousaz E.Tribble J. R.Verhaagen J.Fawcett J.Martin K. R.Williams P. A.Osborne A. Published on 2023 Metadata Gene Ther. 2023 Jun;30(6):503-519. doi: 10.1038/s41434-022-00380-z. Epub 2023 Jan 13.

New Model of Ventral Spinal Cord Lesion Induced by Balloon Compression in Rats

 DepartmentDepartment of Neuroregeneration Centre for Reconstructive Neuroscience AutořiKrůpa P.Štěpánková K.Kwok J. C. F.Fawcett J.Cimermanová V.Jendelová P.Urdzíková-Machová L. Published on 2020 Metadata Biomedicines . 2020 Nov 5;8(11):477. doi: 10.3390/biomedicines8110477.

The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function

 DepartmentCentre for Reconstructive Neuroscience AutořiFawcett J.Oohashi T.Pizzorusso T. Published on 2019 Metadata Nat Rev Neurosci. 2019 Aug;20(8):451-465. doi: 10.1038/s41583-019-0196-3. Epub 2019 Jul 1.