Perineuronal nets affect memory and learning after synapse withdrawal
It has been proposed that the cavities in perineuronal nets (PNNs), which contain synapses, can act as a memory store and that they remain stable after synaptic withdrawal (SW) caused by anoxia or hibernation. We monitor place memory before and after SW. Synaptic withdrawal caused only mild memory deficit, which was not worsened by PNNs disruption. After SW, only animals lacking PNNs showed memory restoration and relearning. The results support a role for PNNs in learning, but not in long‑term memory storage.
Ružička, J., Dalecká, M., Šafránková, K., Peretti, D., Jendelová, P., Kwok, J.C.F., Fawcet, J.W.: (2022) Perineuronal nets affect memory and learning after synapse withdrawal. Translational Psychiatry. 12(1):480. doi: 10.1038/s41398-022-02226-z.