Department

Department of Toxicology and Molecular Epidemiology

Research Department

Head of the Department

Pavel Rössner

Education / Academic Qualifications

  • 1998

    Ph.D., RNDr. / Faculty of Science, Charles University in Prague / Molecular and Cell Biology, Genetics and Virology

  • 1994

    Mgr. (M.Sc.) / Faculty of Science, Charles University in Prague / Molecular Biology

Professional Associations

  • Czech and Slovak Environmental Mutagen Society (Vice-Chairperson)
  • Czecho-Slovak Biological Society

Publications

Select year

Transcriptomic and epigenomic profiling reveals alteredresponses to diesel emissions in Alzheimer’s disease both invitro and in population-based data

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiSaveleva L.Červená T.Mengoni C.Šíma M.Krejčík Z.Vrbová K.Sikorová J.Mussalo L.de Crom T. O. E.Šímová Z.Ivanova M.Shahbaz M. A.Penttilä E.Löppönen H.Koivisto A. M.Ikram M. A.Jalava P. I.Malm T.Chew S.Vojtíšek M.Topinka J.Giugno R.Rössner P.Kanninen K. M. Published on 2024 Metadata Alzheimers Dement . 2024 Dec 24. doi: https://doi.org/10.1002/alz.14347.

The Immunomodulatory Effect of Silver Nanoparticles in a Retinal Inflammatory Environment

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiPalacká K.Heřmánková B.Červená T.Rössner P.Zajícová A.Uherkova E.Holáň V.Javorková E. Published on 2024 Metadata Inflammation . 2024 Aug 27. doi: 10.1007/s10753-024-02128-w. Online ahead of print.

Transcriptome changes in humans acutely exposed to nanoparticles during grinding of dental nanocomposites

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiŠímová Z.Šíma M.Pelclova D.Klusackova P.Zdimal V.Schwarz J.Maskova L.Bradna P.Roubickova A.Krejčík Z.Klema J.Rössner P.Rössnerová A. Published on 2024 Metadata Nanomedicine (Lond) . 2024 Jul 14;19(17):1511-1523. doi: 10.1080/17435889.2024.2362611. Epub 2024 Jul 2.

The effect of air pollution on selected immune system parameters, 8-isoprostane, and alpha-1-antitrypsin of people living in environmentally distinct regions

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiJiřík V.Machaczka O.Riedlová P.Kramná D.Siemiatkowski G.Ośródka L.Krajny E.Ambrož A.Topinka J.Rössner P. Published on 2024 Metadata Environmental Sciences Europe, Published: 02 July 2024, Volume 36, article number 125, (2024)

Gene expression profiles and protein-protein interaction networks in THP-1 cells exposed to metal-based nanomaterials

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiŠíma M.Líbalová H.Závodná T.Vrbová K.Kléma J.Rössner P. Published on 2024 Metadata Environ Toxicol Pharmacol . 2024 Jun:108:104469. doi: 10.1016/j.etap.2024.104469. Epub 2024 May 15.

Genetic alteration profiling in middle-aged women acutely exposed during the mechanical processing of dental nanocomposites

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiRössnerová A.Chvojková I.Elzeinová F.Pelclova D.Klusackova P.Zdimal V.Ondrackova L.Bradna P.Roubickova A.Šímová Z.Rössner P. Published on 2024 Metadata Environ Toxicol Pharmacol. 2024 Jun:108:104462. doi: 10.1016/j.etap.2024.104462. Epub 2024 May 6.

The Genotoxicity of Organic Extracts from Particulate Emissions Produced by Neat Gasoline (E0) and a Gasoline-Ethanol Blend (E15) in BEAS-2B Cells

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiLíbalová H.Závodná T.Elzeinová F.Barošová H.Červená T.Milcová A.Vaňková J.Paradeisi F.Vojtisek-Lom M.Sikorová J.Topinka J.Rössner P. Published on 2023 Metadata J Xenobiot . 2023 Dec 21;14(1):1-14. doi: 10.3390/jox14010001.

Differential DNA damage response and cell fate in human lung cells after exposure to genotoxic compounds

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiLíbalová H.Závodná T.Margaryan H.Elzeinová F.Milcová A.Vrbová K.Barošová H.Červená T.Topinka J.Rössner P. Published on 2023 Metadata Toxicol In Vitro. 2024 Feb:94:105710. doi: 10.1016/j.tiv.2023.105710. Epub 2023 Oct 13.

The Impact of Metal Nanoparticles on the Immunoregulatory and Therapeutic Properties of Mesenchymal Stem Cells.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiHoláň V.Červená T.Zajícová A.Heřmánková B.Echalar B.Palacká K.Rössner P.Javorková E. Published on 2023 Metadata Stem Cell Reviews and Reports.19: 1360-1369.

Effects of antimicrobial metal nanoparticles on characteristics and function properties of mouse mesenchymal stem cells.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiEchalar B.Dostalová D.Palacká K.Javorková E.Heřmánková B.Červená T.Zajícová A.Holáň V.Rössner P. Published on 2023 Metadata Toxicology in Vitro. 87: 105536.

The impact of extractable organic matter from gasoline and alternative fuel emissions on bronchial cell models (BEAS-2B, MucilAir (TM)).

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiŠíma M.Červená T.Elzeinová F.Ambrož A.Beránek V.Vojtíšek-Lom M.Kléma J.Ciganek M.Rössner P. Published on 2022 Metadata Toxicology in vitro. 80: 105316.

Maternal Diet Quality and Health Status of Newborns.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiPavlíková H.Ambrož A.Hoňková K.Chvojková I.Šrám R.Rössner P.Topinka J.Gramblička T.Parizek O.Parizkova D.Pulcmanová J.Rössnerová A. Published on 2022 Metadata Foods. 11(23): 3893.

Genome-Wide DNA Methylation in Policemen Working in Cities Differing by Major Sources of Air Pollution.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiHoňková K.Rössnerová A.Chvojková I.Milcová A.Margaryan H.Pastorková A.Ambrož A.Rössner P.Jirik V.Rubeš J.Šrám R.Topinka J. Published on 2022 Metadata International Journal of Molecular Sciences. 23(3):1666.

Oxidative Stress and Antioxidant Response in Populations of the Czech Republic Exposed to Various Levels of Environmental Pollutants.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiAmbrož A.Rössner P.Rössnerová A.Hoňková K.Milcová A.Pastorková A.Klema J.Pulkrabová J.Pařízek O.Vondrášková V.Zelenka J.Vrzáčková N.Schmuczerová J.Topinka J.Šrám R. Published on 2022 Metadata International Journal of Environmental Research and Public Health. Volume. 19(6): 3609.

The Impact of Air Pollution Exposure on the MicroRNA Machinery and Lung Cancer Development.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiŠíma M.Rössnerová A.Šímová Z.Rössner P. Published on 2021 Metadata Journal of Personalized Medicine. 11(1):60.

Individual DNA Methylation Pattern Shifts in Nanoparticles-Exposed Workers Analyzed in Four Consecutive Years.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiRössnerová A.Hoňková K.Chvojková I.Pelcová D.Ždímal V.Hubáček J. A.Lischková L.Vlčková Š.Ondráček J.Dvořáčková Š.Topinka J.Rössner P. Published on 2021 Metadata International Journal of Molecular Sciences. 22(15): 7834.

In vitro exposure to complete engine emissions – a mini-review.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiRössner P.Červená T.Vojtisek-Lom M. Published on 2021 Metadata Toxicology. 462: 152953

Markers of lipid oxidation and inflammation in bronchial cells exposed to complete gasoline emissions and their organic extracts.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiRössner P.Červená T.Vojtíšek-Lom M.Neca J.Ciganek, M.Vrbová K.Ambrož A.Nováková Z.Elzeinová F.Šíma M.Šímová Z.Holáň V.Beránek V.Pechout M.Macoun D.Rössnerová A.Topinka J. Published on 2021 Metadata Chemosphere. 281: 130833.

Biomonitoring of 89 POPs in blood serum samples of Czech city policemen.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiPolachová A.Gramblicka T.Bechynská K.Parizek O.Parizková D.Dvořáková D.Hoňková K.Rössnerová A.Rössner P.Šrám R.Topinka J.Pulkrabová J. Published on 2021 Metadata Environmental Pollution. 291: 118140.

International database comparison of results with the comet assay in human biomonitoring. Baseline frequency of DNA damage and effect of main confounders.

 DepartmentDepartment of Molecular Biology of Cancer Department of Toxicology and Molecular Epidemiology AutořiMilić M.Ceppi M.Bruzzone M.Azqueta A.Brunborg G.Godschalk R.Koppen G.Langie S.Møller P.Teixeira J. P.Alija A.Anderson D.Andrade V.Andreoli C.Asllani F.Bangkoglu E. E.Barančoková M.Basaran N.Boutet-Robinet E.Buschini A.Cavallo D.Pereira C. C.Costa C.Costa S.Da Silva J.Del Bo‘ C.Srećković V. D.Djelić N.Dobrzyńska M.Duračková Z.Dvořáková M.Gajski G.Galati S.García Lima O.Giovannelli L.Goroshinskaya I. A.Grindel A.Gutzkow K. B.Hernández A.Hernández C.Holven K. B.Ibero-Baraibar I.Ottestad I.Kadioglu E.Kažimirová A.Kuznetsova E.Ladeira C.Laffon B.Lamonaca P.Lebailly P.Louro H.Cardoso T. M.Marcon F.Marcos R.Moretti M.Moretti S.Najafzadeh M.Nemeth Z.Neri M.Novotna B.Orlow I.Paduchova Z.Pastor S.Perdry H.Spremo-Potparević B.Ramadhani D.Riso P.Rohr P.Rojas E.Rössner P.Safar A.Sardas S.Silva M. J.Sirota N.Smolkova B.Staruchova M.Stetina R.Stopper H.Surikova E. I.Ulven S. M.Ursini C. L.Valdiglesias V.Valverde M.Vodička P.Volkovova K.Wagner K.-H.Živković L.Dušinská M.Collins A. R.Bonassi S. Published on 2021 Metadata Mutation Research-Reviews in Mutation Research. 787: 108371.

Transcription profiles in BEAS-2B cells exposed to organic extracts from particulate emissions produced by a port-fuel injection vehicle, fueled with conventional fossil gasoline and gasoline-ethanol blend.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiLíbalová H.Závodná T.Vrbová K.Sikorová J.Vojtíšek-Lom M.Beránek V.Pechout M.Kléma J.Ciganek M.Machala M.Neca J.Rössner P.Topinka J. Published on 2021 Metadata Mutation Research – Genetic Toxicology and Environmental Mutagenesis. 872: 503414.

Airborne Benzo[a]Pyrene may contribute to divergent Pheno-Endotypes in children.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiChoi H.Dostál M.Pastorková A.Rössner P.Šrám R. Published on 2021 Metadata Environmental Health. 20(1): 40.

Biomarkers of nucleic acid oxidation – A summary state-of-the-art.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiChao M.R.Evans M.D.Hu Ch.W. Ji Y.Møller P.Rössner P.Rössner P.Cooke M.S. Published on 2021 Metadata Redox Biology. 42: 101872.

Ordinary Gasoline Emissions Induce a Toxic Response in Bronchial Cells Grown at Air-Liquid Interface View Web of Science ResearcherID and ORCID.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiČervená T.Vojtíšek-Lom M.Vrbová K.Ambrož A.Nováková Z.Elzeinová F.Šíma M.Beránek V.Pechout M.Macoun D.Kléma J.Rössnerová A.Ciganek M.Topinka J.Rössner P. Published on 2020 Metadata International Journal of Molecular Sciences. 22(1): 79.

Testing Strategies of the In Vitro Micronucleus Assay for the Genotoxicity Assessment of Nanomaterials in BEAS-2B Cells.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiČervená T.Rössnerová A.Závodná T.Sikorová J.Vrbová K.Milcová A.Topinka J.Rössner P. Published on 2021 Metadata Nanomaterials. 11(8):1929.

Effects of various environments on epigenetic settings and chromosomal damage.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiRössnerová A.Elzeinová F.Chvojková I.Hoňková K.Šíma M.Milcová A.Pastorková A.Schmuczerová J.Rössner P.Topinka J.Šrám R. Published on 2023 Metadata Environmental Pollution. 323: 121290.

Metal Nanoparticles with Antimicrobial Properties: The Toxicity Response in Mouse Mesenchymal Stem Cells

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiRössner P.Červená T.Echalar B.Palacká K.Milcová A.Nováková Z.Šíma M.Šímová Z.Hana VaňkováHoláň V. Published on 2023 Metadata Toxics. 2023 Mar 9;11(3):253. doi: 10.3390/toxics11030253.

A possible link between cognitive development in 5 years old children and prenatal oxidative stress.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiBlažková B.Ambrož A.Milcová A.Pastorková A.Rössner P.Solansky I.Veleminsky Jr. J.Veleminsky J.Šrám R. Published on 2022 Metadata Neuroendocrinology Letters. 43(1): 101.

Molecular Responses in THP-1 Macrophage-Like Cells Exposed to Diverse Nanoparticles.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiZávodná T.Javorková E.Vrbová K.Zajícová A.Holáň V.Pinkas D.Philimonenko V.Sikorová J.Kléma J.Topinka J.Rössner P. Published on 2019 Metadata Nanomaterials. 9(5): 687.

Short-term and Long-term Exposure of the MucilAir™ Model to Polycyclic Aromatic Hydrocarbons

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiČervená T.Vrbová K.Rössnerová A.Topinka J.Rössner P. Published on 2019 Metadata Altern Lab Anim . 2019 Mar;47(1):9-18. doi: 10.1177/0261192919841484. Epub 2019 Apr 30.

Nano-TiO2 stability in medium and size as important factors of toxicity in macrophage-like cells.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiZávodná T.Sikorová J.Milcová A.Vrbová K.Kléma J.Pikal P.Lubovská Z.Philimonenko A.Franco F.Topinka J.Rössner P. Published on 2019 Metadata Toxicology in vitro. 54: 178-188.