Department

Department of Neurochemistry

Research Department

Head of the Department

Martin Horák

Education / Academic Qualifications

  • 2005

    Ph.D. / Second Faculty of Medicine, Charles University in Prague / Neuroscience

  • 2001

    Mgr. (M.Sc.) / Faculty of Science, Charles University in Prague / Genetics, molecular biology and virology

Professional Associations

  • Society for Neuroscience
  • Czech Neuroscience Society

Publications

Morphing cholinesterase inhibitor amiridine into multipotent drugs for the treatment of Alzheimer's disease

 DepartmentDepartment of Neurochemistry AutořiMezeiova E.Prchal L.Hrabinova M.Muckova L.Pulkrabkova L.Soukup O.Misiachna A.Janousek J.Fibigar J.Kucera T.Horák M.Makhaeva G. F.Korabecny J. Published on 2024 Metadata Biomed Pharmacother. 2024 Apr:173:116399. doi: 10.1016/j.biopha.2024.116399. Epub 2024 Mar 15.

Subunit-Dependent Surface Mobility and Localization of NMDA Receptors in Hippocampal Neurons Measured Using Nanobody Probes

 DepartmentDepartment of Neurochemistry AutořiKortus S.Řeháková K.Klima M.Kolcheva M.Ladislav M.Langore E.Baráčková P.Netolický J.Misiachna A.Hemelíková K.Humpolickova J.Chalupska D.Silhan J.Kaniaková M.Hrčka Krausová B.Boura E.Zapotocky M.Horák M. Published on 2023 Metadata J Neurosci. 2023 Jun 28;43(26):4755-4774. doi: 10.1523/JNEUROSCI.2014-22.2023. Epub 2023 Jun 7.

Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists.

 DepartmentDepartment of Neurochemistry AutořiKonečný J.Misiachna A.Hrabinová M.Pulkrábková L.Benková M.Prchal L.Kučera T.Kobrlová T.Finger V.Kolcheva M.Kortus S.Jun D.Valko M.Horák M.Soukup O.Korábečný J. Published on 2020 Metadata Biomolecules. 11(1): 3.

Specific pathogenic mutations in the M3 domain of the GluN1 subunit regulate the surface delivery and pharmacological sensitivity of NMDA receptors.

 DepartmentDepartment of Neurochemistry AutořiKolcheva M.Kortus S.Hrčka Krausová B.Baráčková P.Misiachna A.Danačíková Š.Kaniaková M.Hemelíková K.Hotovec M.Řeháková K.Horák M. Published on 2021 Metadata Neuropharmacology. 189: 108528.

7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo.

 DepartmentDepartment of Neurochemistry AutořiKaniaková M.Korábečný J.Holubová K.Kletečková L.Chvojková M.Hakenová K.Prchal L.Novák M.Doležal R.Hepnarová V.Svobodová B.Kučera T.Lichnerová K.Hrčka Krausová B.Horák M.Valeš K.Soukup O. Published on 2021 Metadata Biochemical Pharmacology. 186: 114460.

The Extracellular Domains of GluN Subunits Play an Essential Role in Processing NMDA Receptors in the ER.

 DepartmentDepartment of Neurochemistry AutořiHorák M.Baráčková P.Langore E.Netolický J.Rivas-Ramirez P.Řeháková K. Published on 2021 Metadata Frontiers in Neuroscience. 15: 603715.

Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors.

 DepartmentDepartment of Neurochemistry AutořiGorecki L.Misiachna A.Damborský J.Doležal R.Korábečný J.Čejková L.Hakenová K.Chvojková M.Zdarová Karasová J.Prchal L.Novák M.Kolcheva M.Kortus S.Kortus Š.Valeš K.Horák M.Soukup O. Published on 2021 Metadata European Journal of Medicinal Chemistry. 219: 113434.

Structure-Guided Design of N-Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer’s Disease.

 DepartmentDepartment of Neurochemistry AutořiSvobodová B.Pulkrabová L.Pánek D.Misiachna A.Kolcheva M.Andrýs R.Handl J.Čapek J.Nývltová P.Roušar T.Prchal L.Hepnarová V.Hrabinová M.Mucková L.Tosnerová D.Karabanovich G.Finger V.Soukup O.Horák M.Korabecný J. Published on 2023 Metadata International Journal of Molecular Sciences. 24 (11): 9124.

The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors.

 DepartmentDepartment of Neurochemistry AutořiKolcheva M.Ladislav M.Netolický J.Kortus S.Řeháková K.Hrčka Krausová B.Hemelíková K.Misiachna A.Kádková A.Klíma M.Chalupská D.Horák M. Published on 2023 Metadata Neuropharmacology. 222: 109297.