Research Infrastructures

Czech-Bioimaging (open in a new window) is the national research infrastructure for biological and medical imaging and provides an open acces for various imaging technologies. It is also the part of the larger international project Euro-Bioimaging (open in a new window).

EATRIS-CZ (open in a new window) is an abbreviation for European Advanced Translational Research Infrastructure in Medicine. It is one of the largest research infrastructures in the Czech Republic and involves the leading biomedical research and development centres. EATRIS provides access to a wide range of preclinical and clinical expertise and facilities.

The focus of IEM CAS in the EATRIS infrastructure is mainly, but not only within the domain of advanced therapy medicinal products (ATMPs). IEM CAS has the expertise and technologies that enable to perform research and commercial projects of basic and applied research in the development of ATMPs. IEM CAS is accredited for the work with genetically modified organisms (in the first and second risk categories), embryonic stem cells and for the use of experimental animals (mouse, rat, guinea pig). Animal models focus on spinal cord injury, stroke and cerebral ischemia, healing of skin, bone, cartilage and cornea defects, as well as models of neurodegenerative diseases such as Alzheimer’s disease and dementia.

The breeding of animals and experiments are conducted under conventional or IVC conditions. At present, a new facility for breeding is being established. Another component of our research is the testing of nanomaterials and the evaluation of the potential negative effects of nanoparticles on human health.

Devices provided and provided by IEM for use by external entities

• Fully equipped laboratories for genomic and proteomic analysis: MiSeq Illumina Sequencer, iScan Illumina Microarray Analyzer, Apogee A-50 Micro Cytometer, QuantStudio ™ 6 Flex Real-Time PCR System, StepOne Plus Real-Time PCR System, Bugbox Plus, Zetasizer Nano ZS, Agilent Fragment Analyzer, Roche LightCycler® 480 Real-Time PCR System
• Cell Culture Laboratories (BSL2)
• Histological laboratories
• Electrophysiological laboratories (Patch clamp)
• Laboratories with calcium imaging and neurosurgery equipment (Neurostar Stereotaxic Robot)
• Wide range of behavioural tests with appropriate analysis (MotoRater, Morris Water Maze, von Frey)
• Imaging technologies for live and fixed specimens: Zeiss LSM 5 Duo Confocal Microscope, Olympus FV1200 MPE, Two-photon Microscope (Ultima IV), Electron Microscope (Philips Electron Optics), Leica DMI 6000B Fluorescence Microscope with TissueGnostics Image Analysis, Lightsheet Microscope (LaVision ), Olympus SpinSR10 Spinning Disk Confocal Super Resolution Microscope

NanoEnviCz (open in a new window) integrates the infrastructure facilities of Czech research organisations for research in nanotechnology sciences. The program is focused on research in nanomaterials and nanocomposites for environmental and related applications. Our services include controllable syntheses of nanomaterials, their complex chemical, structural, morphological and surface characterisation, tuning their functional properties, and monitoring their potential toxicity and hazard.