Department

Department of Neuroregeneration

Research Department

Head of the Department

Pavla Jendelová

Centre for Reconstructive Neuroscience

Research Centre

 James Fawcett

Head of the Department

James Fawcett

Education / Academic Qualifications

  • 2014

    doc. (Assoc. Prof.) / Second Faculty of Medicine, Charles University in Prague / Physiology in Medicine

  • 1999

    Ph.D. / First Faculty of Medicine, Charles University in Prague / Neuroscience

  • 1988

    RNDr. (M.Sc.) / Faculty of Science, Charles University in Prague / Biology

Professional Associations

  • American Society for Neural Therapy and Repair – ASNTR
  • Czech Neuroscience Society
  • Czech Society for Gene Therapy and Stem Cells
  • Ministry of Education and Science for the control of research on human embryonic stem cells (expert)
  • Physiological Society

Publications

Select year

Dizocilpine derivatives as neuroprotective NMDA receptor antagonists without psychomimetic side effects

 DepartmentDepartment of Neurochemistry AutořiKonecny J.Misiachna A.Chvojkova M.Kletečková L.Kolcheva M.Novak M.Prchal L.Ladislav M.Hemelíková K.Netolický J.Hrabinova M.Kobrlova T.Zdarova Karasova J.Pejchal J.Fibigar J.Vecera Z.Kucera T.Jendelová P.Baráčková P.Langore E.Doderović J.Pang Y.P.Valeš K.Korabecny J.Soukup O.Horák M. Published on 2024 Metadata Eur J Med Chem . 2024 Dec 15:280:116981. doi: 10.1016/j.ejmech.2024.116981. Epub 2024 Oct 18.

Inhibition of PHLDA3 expression in human superoxide dismutase 1-mutant amyotrophic lateral sclerosis astrocytes protects against neurotoxicity

 DepartmentDepartment of Neuroregeneration Centre for Reconstructive Neuroscience Department of Cellular Neurophysiology AutořiSzebényi K.Vargová I.Petrova V.Turečková J.Gibbons G. M.Řehořová M.Abdelgawad M.Sándor A.Marekova D.Kwok J.C.F.Jendelová P.Fawcett J.Lakatos A. Published on 2024 Metadata Brain Commun . 2024 Jul 25;6(4):fcae244. doi: 10.1093/braincomms/fcae244. eCollection 2024.

mTOR pathway inhibition alters proliferation as well as differentiation of neural stem cells

 DepartmentDepartment of Neuroregeneration Department of Neurochemistry AutořiRomanyuk N.Šintáková K.Arzhanov I.Horák M.Gandhi Ch.Jhanwar-Uniyal M.Jendelová P. Published on 2024 Metadata Front Cell Neurosci . 2024 May 15:18:1298182. doi: 10.3389/fncel.2024.1298182. eCollection 2024.

Toxicity of Large and Small Surface-Engineered Upconverting Nanoparticles for In Vitro and In Vivo Bioapplications

 DepartmentDepartment of Neuroregeneration AutořiUrdzíková-Machová L.Marekova D.Vasylyshyn T. Matouš P.Patsula V.Oleksa V.Shapoval O.Vosmanská M.Liebl D.Benda A.Herynek V.Horák D.Jendelová P. Published on 2024 Metadata Int J Mol Sci . 2024 May 13;25(10):5294. doi: 10.3390/ijms25105294.

Storage conditions affect the composition of the lyophilized secretome of multipotent mesenchymal stromal cells

 DepartmentDepartment of Neuroregeneration AutořiRohulska O.Vackova I.Prazak S.Turnovcová K.Kubinova S.Bacakova L.Jendelová P.Petrenko Y. Published on 2024 Metadata Sci Rep . 2024 May 3;14(1):10243. doi: 10.1038/s41598-024-60787-z.

Low oral dose of 4-methylumbelliferone reduces glial scar but is insufficient to induce functional recovery after spinal cord injury

 DepartmentCentre for Reconstructive Neuroscience Department of Neuroregeneration AutořiŠtěpánková K.Chudíčková M.Šimková Z.Varea N.Kubinová Š.Urdzíková-Machová L.Jendelová P.Kwok J.C.F. Published on 2023 Metadata Sci Rep. 2023 Nov 6;13(1):19183. doi: 10.1038/s41598-023-46539-5.

The activation of dormant ependymal cells following spinal cord injury

 DepartmentDepartment of Neuroregeneration AutořiRodriguez-Jimenez F. J.Jendelová P.Erceg S. Published on 2023 Metadata Stem Cell Res Ther. 2023 Jul 5;14(1):175. doi: 10.1186/s13287-023-03395-4.

Integrin-Driven Axon Regeneration in the Spinal Cord Activates a Distinctive CNS Regeneration Program

 DepartmentCentre for Reconstructive Neuroscience Department of Neuroregeneration AutořiCheah M.Cheng Y.Petrova V.Cimpean A.Jendelová P.Swarup V.Woolf C. J.Geschwind D. H.Fawcett J. Published on 2023 Metadata J Neurosci. 2023 Jun 28;43(26):4775-4794. doi: 10.1523/JNEUROSCI.2076-22.2023. Epub 2023 Jun 5.

Polymer-coated hexagonal upconverting nanoparticles: chemical stability and cytotoxicity

 DepartmentDepartment of Neuroregeneration AutořiPatsula V.Marekova D.Jendelová P.Nahorniak M.Shapoval O.Matouš P.Oleksa V.Konefał R.Vosmanská M.Urdzíková-Machová L.Horák D. Published on 2023 Metadata Front Chem. 2023 Jun 23:11:1207984. doi: 10.3389/fchem.2023.1207984. eCollection 2023.

Long-Term Cultures of Spinal Cord Interneurons.

 DepartmentCentre for Reconstructive Neuroscience Department of Cellular Neurophysiology Department of Neuroregeneration AutořiVargová I.Kriška J.Kwok J.C.F.Fawcett J.Jendelová P. Published on 2022 Metadata Frontiers in Cellular Neuroscience. 16: 827628

Perineuronal nets affect memory and learning after synapse withdrawal.

 DepartmentCentre for Reconstructive Neuroscience AutořiRůžička J.Dalecká M.Šafránková K.Peretti D.Jendelová P.Kwok J.C.F.Fawcett J. Published on 2022 Metadata Translational Psychiatry. 12(1):480.

Subretinal Implantation of Human Primary RPE Cells Cultured on Nanofibrous Membranes in Minipigs.

 DepartmentDepartment of Neuroregeneration AutořiLytvynchuk L.Ebbert A.Studenovská H.Nagymihaly R.Josifovska N.Rais D.Popelka S.Tichotová L.Nemesh Y.Čížková J.Juhásová J.Juhás Š.Jendelová P.Franeková J.Kozak I.Erceg S.Erceg S.Straňák Z.Müller B.Ellederová Z.Motlík J.Stieger K.Ardan T.Petrovski G. Published on 2022 Metadata Biomedicines. 10 (3): 669.

Neurogenesis as a Tool for Spinal Cord Injury.

 DepartmentDepartment of Neuroregeneration AutořiHavelíková K.Smejkalová B.Jendelová P. Published on 2022 Metadata International Journal of Molecular Sciences. 23(7): 3728.

The extracellular matrix and perineuronal nets in memory.

 DepartmentCentre for Reconstructive Neuroscience AutořiFawcett J.Fyhn M.Jendelová P.Kwok J.C.F.Růžička J.Sorg B. Published on 2022 Metadata Molecular Psychiatry. 27(8): 3192-3203.

Involvement of mTOR Pathways in Recovery from Spinal Cord Injury by Modulation of Autophagy and Immune Response. Involvement of mTOR Pathways in Recovery from Spinal Cord Injury by Modulation of Autophagy and Immune Response.

DepartmentDepartment of Neuroregeneration AutořiVargová L.Urdzíková-Machová L.Kárová K.Smejkalová B.Sursal T.Cimermanová V.Turnovcová K.Gandhi Ch.D.Jhanwar-Uniyal M.Jendelová P. Published on 2021 Metadata Biomedicines. 9(6): 593.

Understanding the Biological Basis of Glioblastoma Patient-derived Spheroids.

DepartmentDepartment of Neuroregeneration AutořiTurnovcová K.Marekova D.Sursal T.Krupová M.Gandhi R.Krůpa P.Kaiser R.Herynek V.Netuka D.Jendelová P. Published on 2021 Metadata Anticancer Research. 41(3): 1183-1195.

Planet of the AAVs: The Spinal Cord Injury Episode.

 DepartmentDepartment of Neuroregeneration AutořiŠtěpánková K.Jendelová P.Urdzíková-Machová L. Published on 2021 Metadata Biomedicines. 9(6): 613.

Activation of Neurogenesis in Multipotent Stem Cells CulturedIn Vitroand in the Spinal Cord Tissue After Severe Injury by Inhibition of Glycogen Synthase Kinase-3.

 DepartmentDepartment of Neuroregeneration AutořiRodriguez-Jimenez F.J.Vilches A.Perez-Arago M.A.Clemente E.Roman R.Leal J.Castro A.A.Fustero S.Moreno-Manzano V.Jendelová P.Stojkovic M.Erceg S. Published on 2021 Metadata Neurotherapeutics. 18 (1): 515-533.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

 DepartmentDepartment of Neuroregeneration AutořiKlionsky D.J.Abdel-Aziz A.K.Abdelfatah S.Abdellatif M.Abdoli A.Abel S.Abeliovich H.Abildgaard M.H....Jendelová P....Zwerschke W.Brand-Saberi B.Dong X.C.Kenchappa C.S.Li Z.Lin Y.Oshima S.Rong Y.Sluimer J.C.Stallings C.L.Tong C.K. Published on 2021 Metadata Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280.

Transplantation of Neural Precursors Derived from Induced Pluripotent Cells Preserve Perineuronal Nets and Stimulate Neural Plasticity in ALS Rats.

 DepartmentDepartment of Neuroregeneration AutořiForostyak S.Forostyak O.Kwok J.C.F.Romanyuk N.Řehořová M.Kriška J.Dayanithi G.Raha-Chowdhury R.Jendelová P.Anděrová M.Fawcett J.Syková E. Published on 2020 Metadata International Journal of Molecular Sciences. 21(24):9593.

Gene Correction Recovers Phagocytosis in Retinal Pigment Epithelium Derived from Retinitis Pigmentosa-Human-Induced Pluripotent Stem Cells.

 DepartmentDepartment of Neuroregeneration AutořiArtero-Castro A.Long K.Bassett A.Avila-Fernandez A.Cortón M.Vidal-Puig A.Jendelová P.Rodriguez-Jimenez F.J.Clemente E.Ayuso C.Erceg S. Published on 2021 Metadata International Journal of Molecular Sciences. 22(4): 2092

4-Methylumbeliferone Treatment at a Dose of 1.2 g/kg/Day Is Safe for Long-Term Usage in Rats.

 DepartmentDepartment of Neuroregeneration Centre for Reconstructive Neuroscience AutořiŠtěpánková K.Marekova D.Kubášová K.Sedláček R.Turnovcová K.Vacková I.Kubinová Š.Makovický P.Petrovičová M.Kwok J.C.F.Jendelová P.Urdzíková-Machová L. Published on 2023 Metadata International Journal of Molecular Sciences. 24 (4): 3799.

The Role of Green Tea Catechin Epigallocatechin Gallate (EGCG) and Mammalian Target of Rapamycin (mTOR) Inhibitor PP242 (Torkinib) in the Treatment of Spinal Cord Injury.

 DepartmentDepartment of Neuroregeneration AutořiUrdzíková-Machová L.Cimermanová V.Kárová K.Dominguez J.Štěpánková K.Petrovicová M.Havelíková K.Gandhi Ch.D.Jhanwar-Uniyal M.Jendelová P. Published on 2023 Metadata Antioxidants. 12(2): 363.

Chemical and Colloidal Stability of Polymer-Coated NaYF4:Yb,Er Nanoparticles in Aqueous Media and Viability of Cells: The Effect of a Protective Coating.

 DepartmentDepartment of Neuroregeneration AutořiNahorniak M.Patsula V.Marekova D.Matous P.Shapoval O.Oleksa V.Vosmanská M.Urdzíková-Machová L.Jendelová P.Herynek V.Horák D. Published on 2023 Metadata International Journal of Molecular Sciences. 24(3): 2724.

Chemical and Colloidal Stability of Polymer-Coated NaYF4:Yb,Er Nanoparticles in Aqueous Media and Viability of Cells: The Effect of a Protective Coating

 DepartmentDepartment of Neuroregeneration AutořiNahorniak M.Patsula V.Marekova D.Matouš P.Shapoval O.Oleksa V.Vosmanská M.Urdzíková-Machová L.Jendelová P.Herynek V.Horák D. Published on 2023 Metadata Int J Mol Sci. 2023 Feb 1;24(3):2724. doi: 10.3390/ijms24032724.

New Model of Ventral Spinal Cord Lesion Induced by Balloon Compression in Rats

 DepartmentDepartment of Neuroregeneration Centre for Reconstructive Neuroscience AutořiKrůpa P.Štěpánková K.Kwok J.C.F.Fawcett J.Cimermanová V.Jendelová P.Urdzíková-Machová L. Published on 2020 Metadata Biomedicines . 2020 Nov 5;8(11):477. doi: 10.3390/biomedicines8110477.

Deciphering Retinal Diseases through the Generation of Three Dimensional Stem Cell-derived Organoids.

 DepartmentDepartment of Neuroregeneration AutořiArtero Castro A.Rodríguez Jimenez F.J.Jendelová P.Erceg S. Published on 2019 Metadata Stem Cells. 37(12): 1496-1504.

Short Review: Investigating ARSACS: models for understanding cerebellar degeneration.

 DepartmentDepartment of Neuroregeneration AutořiArtero Castro A.Machuca C.Rodriguez Jimenez F.J.Jendelová P.Erceg S. Published on 2019 Metadata Neuropathology and Applied Neurobiology. 45(6): 531-537.

The identification of small molecules that stimulate retinal pigment epithelial cells: potential novel therapeutic options for treating retinopathies.

 DepartmentDepartment of Neuroregeneration AutořiArtero-Castro A.Popelka Š.Jendelová P.Motlík J.Ardan T.Jimenez F.J.R.Erceg S. Published on 2019 Metadata Expert Opinion on Drug Discovery. 14 (2): 169-177.