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Cell Nucleus Plasticity

Research Department

Group photo of the Department of Cell Nucleus Plasticity team

The department is focused on the research of the early embryogenesis of mammals and the change in the plasticity of the cell nucleus, which accompanies the process of differentiation and dedifferentiation. These processes are accompanied by a significant change in the morphology of the nuclei and epigenetic remodeling of chromatin. The aim of the department is to characterize the influence of individual nuclear components and to define the role of subnuclear organelles in this process. Currently, the department‘s research focuses on the mechanism and role of active demethylation of the paternal genome after fertilization. Another topic is the impact of A‑ and B-type nuclear lamin depletion on early development.

Helena Fulková

Head of the Department
Helena Fulková, Ph.D.

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Pavel Čabart, Ph.D.

Tereza Ilčíková, M.Sc.

Natálie Novotná, M.Sc.

Ondřej Peller, B.Sc.

Tereza Znachorová, M.Sc.

PhD Students

Nataliia Dudko, MSc.

Important Results

Nuclear lamins play a key role in mammalian development

Nuclear lamins are key nuclear proteins and at least one member of this family of proteins is detectable in the nucleus of the majority of cells. However, althought this might indicate that nuclear lamins are encoded by esential genes at the cellular level, their role especially in development remains highly controversial.

Lamin AC in early embryos. The presence of lamin AC has been traditionally linked to an advanced differentiation of cells. However, it is paradoxically also clearly detectable in mouse zygotes, which are totipotent.



Paul, J.Ch., Fulka, H.: (2022) Nuclear Lamins: Key Proteins for Embryonic Development. Biology-Basel. 11(2): 198. doi: 10.3390/biology11020198. PMID: 35205065