Department

Department of Molecular Biology of Cancer

Research Department

Head of the Department

Veronika Vymetálková

Education / Academic Qualifications

  • 2009

    Ph.D. / Third Faculty of Medicine, Charles University in Prague / Cell and Molecular Biology, Genetics and Virology

  • 2005

    Ing. (M.Sc.) / Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava / Biochemistry

Professional Associations

  • Czech Health Research Council, Agency for Health Research of the Czech Republic
  • GECCO – Genetics and Epidemiology of Colorectal Cancer Consortium
  • TRANSCOLONCAN – Translational Research for Prevention and Stratification of Colorectal Cancer

 

Publications

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Plasma miR-122-5p and miR-142-5p and their role in chemoresistance of colon cancer patients

 DepartmentDepartment of Molecular Biology of Cancer AutořiČervená K.Landecka A.Selvi S.Horák J.Novosadova V.Manakova K.Levy M.Vymetálková V. Published on 2024 Metadata Mutagenesis . 2024 Sep 14:geae023. doi: 10.1093/mutage/geae023. Online ahead of print.

Fecal miRNA profiles in colorectal cancers with mucinous morphology

 DepartmentDepartment of Molecular Biology of Cancer AutořiNaccarati A.Dragomir M. P.Tarallo S.Gagliardi A.Alberini V.Buchler T.Gallo G.Vymetálková V.Vodičková L.Vodička P.Pardini B.Ferrero G. Published on 2024 Metadata Mutagenesis . 2024 Jun 6:geae015. doi: 10.1093/mutage/geae015. Online ahead of print.

Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

 DepartmentDepartment of Molecular Biology of Cancer AutořiChen Z.Guo X.Tao R.Huyghe J. R.Law P. J.Fernandez-Rozadilla C.Ping J.Jia G.J. LongLi C....Vodička P.Vodičková L.Vymetálková V....Hsu L.Cai Q.Dunlop M. G.Gruber S. B.Houlston R. S.Moreno V.Casey G.Peters U.Tomlinson I.Zheng W. Published on 2024 Metadata Nat Commun . 2024 Apr 26;15(1):3557. doi: 10.1038/s41467-024-47399-x.

Editorial: Strategies in overcoming the chemoresistance in colorectal cancer

 DepartmentDepartment of Molecular Biology of Cancer AutořiVodenková S.Buchler T.Vymetálková V. Published on 2023 Metadata Front Oncol . 2023 Oct 2:13:1295204. doi: 10.3389/fonc.2023.1295204. eCollection 2023.

Elucidating the Risk of Colorectal Cancer for Variants in Hereditary Colorectal Cancer Genes

 DepartmentDepartment of Molecular Biology of Cancer AutořiThomas M.Qu C.Wang X.Huyghe J. R.Joo J. E.Georgeson P.Arndt V.Berndt S. I.Bézieau S.Bien S. A.Bishop D. T.Brenner H.Brezina S.Burnett-Hartman A.Campbell P. T.Casey G.Castellví-Bel S.Chan A. T.Chang-Claude J.Chen X.Conti D. V.Cremolini C.Diergaarde B.Figueiredo J. C.FitzGerald L. M.Gago-Dominguez M.Gallinger S.Giles G. G.Gsu A.Gunter M. J.Hampe J.Hampel H.Harrison T. A.Hoffmeister M.Keku T. O.Kundaje A.Le Marchand L.Lenz H.-J.Li C. I.Li L.Lin Y.Lindblom A.Moreno V.Murphy N.Newcomb P. A.Newton C. C.Obón-Santacana M.Ogino S.Pai R. K.Palmer J. R.Pearlman R.Pharoah P. D. P.Phipps A. I.Platz E. A.Potter J. D.Rennert G.Sakoda L. C.Schafmayer C.Schmit S. L.Schoen R. E.Slattery M. L.Stadler Z. K.Steinfelder R. S.Thibodeau S. N.Ulrich C. M.Um C. Y.van Duijnhoven F. J. B.Van Guelpen B.Visvanathan K.Vodička P.Vodičková L.Vymetálková V.Weinstein S. J.White E.Winship I. M.Wolk A.Gruber S. B.Jenkins M. A.Hsu L.Buchanan D. D.Peters U. Published on 2023 Metadata Gastroenterology. 2023 Oct;165(4):1070-1076.e3. doi: 10.1053/j.gastro.2023.06.032. Epub 2023 Jul 14.

Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations

 DepartmentDepartment of Molecular Biology of Cancer AutořiThomas M.Su Y-R.Rosenthal E. A.Sakoda L. C.Schmit S. L.Timofeeva M. N.Chen Z.Fernandez-Rozadilla C.Law P. J.Murphy N.Carreras-Torres R.Diez-Obrero V.van Duijnhoven F. J. B.Jiang S.Shin A.Wolk A.Phipps A. I.Burnett-Hartman A.Gsur A.Chan A. T.Zauber A. G.Wu A. H.Lindblom A.Um C. Y.Tangen C. M.Gignoux C.Newton C.Haiman C. A.Qu C.Bishop D. T.Buchanan D. D.Crosslin D. R.Conti D. V.Kim D-H.Hauser E.White E.Siegel E.Schumacher F. R.Rennert G.Giles G. G.Hampel H.Brenner H.Oze I.Oh J. H.Lee J. K.Schneider J. L.Chang-Claude J.Kim J.Huyghe J. R.Zheng J.Hampe J.Greenson J.Hopper J. L.Palmer J. R.Visvanathan K.Matsuo K.Matsuda K.Jung K. J.Li L.Le Marchand L.Vodičková L.Bujanda L.Gunter M. J.Matejcic M.Jenkins M. A.Slattery M. L.D'Amato M.Wang M.Hoffmeister M.Woods M. O.Kim M.Song M.Iwasaki M.Du M.Udaltsova N.Sawada N.Vodička P.Campbell P. T.Newcomb P. A.Cai Q.Pearlman R.Pai R. K.Schoen R. E.Steinfelder R. S.Haile R. W.Vandenputtelaar R.Prentice R. L.Küry S.Castellví-Bel S.Tsugane S.Berndt S. I.Lee S. C.Brezina S.Weinstein S. J.Chanock S. J.Jee S. H.Kweon S-S.Vadaparampil S.Harrison T. A.Yamaji T.Keku T. O.Vymetálková V.Arndt V.Jia W-H.Shu X-O.Lin Y.Ahn Y-O.Stadler Z. K.Van Guelpen B.Ulrich C. M.Platz E. A.Potter J. D.Li C. I.Meester R.Moreno V.Figueiredo J. C.Casey G.Lansdorp Vogelaar I.Dunlop M. G.Gruber S. B.Hayes R. B.Pharoah P. D.Houlston R. S.Jarvik G. P.Tomlinson I. P.Zheng W.Corley D. A.Peters U.Hsu L. Published on 2023 Metadata Nat Commun. 2023 Oct 2;14(1):6147. doi: 10.1038/s41467-023-41819-0.

A Fecal MicroRNA Signature by Small RNA Sequencing Accurately Distinguishes Colorectal Cancers: Results From a Multicenter Study

 DepartmentDepartment of Molecular Biology of Cancer AutořiPardini B. Ferrero G.Tarallo S.Gallo G.Francavilla A.Licheri N.Trompetto M.Clerico G.Senore C.Peyre S.Vymetálková V.Vodičková L.Liska V.Vycital O.Levy M.Macinga P.Hucl T.Budinska E.Vodička P.Cordero F.Naccarati A. Published on 2023 Metadata Gastroenterology. 2023 May 30;S0016-5085(23)00811-9. doi: 10.1053/j.gastro.2023.05.037. Online ahead of print.

Monitoring of telomere dynamics in peripheral blood leukocytes in relation to colorectal cancer patients' outcomes.

 DepartmentDepartment of Molecular Biology of Cancer AutořiTomášová K.Kroupa M.Zinková A.Korabečná M.Vymetálková V.Skrobánek P.Sojka L.Levy M.Hemminki K.Liška V.Hošek P.Kumar R.Vodičková L.Vodička P. Published on 2022 Metadata Frontiers in Oncology. 12:962929.

Discovery of Long Non-Coding RNA MALAT1 Amplification in Precancerous Colorectal Lesions.

 DepartmentDepartment of Molecular Biology of Cancer AutořiŠišková A.Král J.Drabová J.Červená K.Tomášová K.Jungwirth J.Hucl T.Kohout P.Summerová S.Vodičková L.Vodička P.Vymetálková V. Published on 2022 Metadata International Journal of Molecular Sciences. 23(14): 7656.

The Associations of Selenoprotein Genetic Variants with the Risks of Colorectal Adenoma and Colorectal Cancer: Case-Control Studies in Irish and Czech Populations.

 DepartmentDepartment of Molecular Biology of Cancer AutořiMukhtar M.Ashfield N.Vodičková L.Vymetálková V.Levy M.Liska V.Bruha J.Bendová P.O‘Sullivan J.Doherty G.Sheahan K.Nolan B.Vodička P.Hughes D. Published on 2022 Metadata Nutrients. 14(13): 2718.

Oxidative Damage in Sporadic Colorectal Cancer: Molecular Mapping of Base Excision Repair Glycosylases MUTYH and hOGG1 in Colorectal Cancer Patients.

DepartmentDepartment of Molecular Biology of Cancer AutořiKavec M.Urbanová M.Makovický P.Opattová A.Tomášová K.Kroupa M.Kostovciková K.Šišková A.Navvabi N.Schneiderová M.Vymetálková V.Vodičková L.Vodička P. Published on 2022 Metadata International Journal of Molecular Sciences. 23(10): 5704.

Mutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition.

 DepartmentDepartment of Molecular Biology of Cancer AutořiJungwirth J.Urbanová M.Boot A.Hošek P.Bendová P.Šišková A.Švec J.Kment M.Tůmová D.Summerová S.Beneš Z.Buchler T.Kohout P.Hucl T.Matěj R.Vodičková L.van Wezel T.Vodička P.Vymetálková V. Published on 2022 Metadata Scientific Reports. 12(1): 2570.

MALAT1 in colorectal cancer: Its implication as a diagnostic, prognostic, and predictive biomarker.

 DepartmentDepartment of Molecular Biology of Cancer AutořiČervená K.Vodenková S.Vymetálková V. Published on 2022 Metadata Gene. 843: 146791.

Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk.

 DepartmentDepartment of Molecular Biology of Cancer AutořiThomas M.Sakoda L. C.Hoffmeister M.Rosenthal E. A.Lee J. K.van Duijnhoven F. J. B.Platz E. A.Wu A. H.Dampier C. H.de la Chapelle A.Wolk A.Joshi A. D.Burnett-Hartman A.Gsur A.Lindblom A.Castells A.Win A. K.Namjou B.Van Guelpen B.Tangen C. M.He Q.Li C. I.Schafmayer C.Joshu C. E.Ulrich C. M.Bishop D. T.Buchanan D. D.Schaid D.Drew D. A.Muller D. C.Duggan D.Crosslin D. R.Albanes D.Giovannucci E. L.Larson E.Qu F.Mentch F.Giles G. G.Hakonarson H.Hampel H.Stanaway I. B.Figueiredo J. C.Huyghe J. R.Minnier J.Chang-Claude J.Hampe J.Harley J. B.Visvanathan K.Curtis K. R.Offit K.Li L.Le Marchand L.Vodickova L.Gunter M. J.Jenkins M. A.Slattery M. L.Lemire M.Woods M. O.Song M.Murphy N.Lindor N. M.Dikilitas O.Pharoah P. D. P.Campbell P. T.Newcomb P. A.Milne R. L.MacInnis R. J.Castellví-Bel S.Ogino S.Berndt S. I.Bézieau S.Thibodeau S. N.Gallinger S. J.Zaidi S. H.Harrison T. A.Keku T. O.Hudson T. J.Vymetálková V.Moreno V.Martín V.Arndt V.Wei W.-Q.Chung W.Su Y.-R.Hayes R. B.White E.Vodička P.Casey G.Gruber S. B.Schoen R. E.Chan A. T.Potter J. D.Brenner H.Jarvik G. P.Corley D. A.Peters U.Hsu L. Published on 2020 Metadata American Journal of Human Genetics. 107(3): 432-444.

Glyphosate Interaction with eEF11 Indicates Altered Protein Synthesis: Evidence for Reduced Spermatogenesis and Cytostatic Effect.

 DepartmentDepartment of Molecular Biology of Cancer AutořiSopko B.Tejral G.Bitti G.Sainz J.Garcia-Verdejo F.J.Martinez-Bueno M.Kumar A.Sanchez-Maldonado J.M.Diez-Villanueva A.Vodičková L.Vymetálková V.Sanchez V.M.Da Silva F.M.I.Sampaio-Marques B.Březina S.Butterbach K.ter Horst R.Hoffmeister M.Ludovico P.Jurado M.Li Y.Abate M.Medvediková M.Hajduch M.Chloupek J.Fajmonová J.Skoric M.Amler E.Erban T. Published on 2021 Metadata ACS Omega. 6(23):14848-14857.

Polymorphisms within Autophagy-Related Genes Influence the Risk of Developing Colorectal Cancer: A Meta-Analysis of Four Large Cohorts.

 DepartmentDepartment of Molecular Biology of Cancer AutořiSainz J.Garcia-Verdejo F.J.Martinez-Bueno M.Kumar A.Sanchez-Maldonado J.M.Diez-Villanueva A.Vodičková L.Vymetálková V.Sanchez V.M.Da Silva F.M.I.Sampaio-Marques B.Březina S.Butterbach K.ter Horst R.Hoffmeister M.Ludovico P.Jurado M.Sanchez-Rovira P.Netea M.G.Gsur A.Vodička P.Moreno V.Hemminki K.Brenner H.Chang-Claude J.Forsti A. Published on 2021 Metadata Cancer. 13(6):1258.

DNA Repair Gene Polymorphisms and Chromosomal Aberrations in Exposed Populations.

 DepartmentDepartment of Molecular Biology of Cancer AutořiNiazi Y.Thomsen H.Smolková B.Vodičková L.Vodenková S.Kroupa M.Vymetálková V.Kazimírová A.Barancoková M.Volkovová K.Staruchová M.Hoffmann P.Noethen M.M.Dusinska M.Musak L.Vodička P.Hemminki K.Foersti A. Published on 2021 Metadata Frontiers in Genetics. 12: 691947.

DNA repair gene polymorphisms and chromosomal aberrations in healthy, nonsmoking population.

DepartmentDepartment of Molecular Biology of Cancer AutořiNiazi Y.Thomsen H.Smolková B.Vodičková L.Vodenková S.Kroupa M.Vymetálková V.Kazimírová A.Barancoková M.Volkovová K.Staruchová M.Hoffmann P.Noethen M.Dusinská M.Musak L.Vodička P.Foersti A.Hemminki K. Published on 2021 Metadata DNA Repair. 101: 103079.

Telomere length in peripheral blood lymphocytes related to genetic variation in telomerase, prognosis and clinicopathological features in breast cancer patients.

 DepartmentDepartment of Molecular Biology of Cancer Department of Toxicology and Molecular Epidemiology AutořiKroupa M.Rachakonda S.Vymetálková V.Tomášová K.Liška V.Vodenková S.Čumová A.Rössnerová A.Vodičková L.Hemminki K.Souček P.Kumar R.Vodička P. Published on 2020 Metadata Mutagenesis. 35(6):491-497.

Genetic architectures of proximal and distal colorectal cancer are partly distinct.

 DepartmentDepartment of Molecular Biology of Cancer AutořiHuyghe J.R.Harrison T.A.Bien S.A.Hampel H.Figueiredo J.C.Schmit S.L.Conti D.V.Chen S.Qu C.Lin Y.Barfield R.Baron J.A.Cross A.J.Diergaarde B.Duggan D.Harlid S.Imaz L.Kang H.M.Levine D.M.Perduca V.Perez-Cornago A.Sakoda L.C.Schumacher F.R.Slattery M.L.Toland A.E.van Duijnhoven F.J.B.Van Guelpen B.Agudo A.Albanes D.Alonso M.H.Anderson K.Arnau-Collell C.Arndt V.Banbury B.L.Bassik M.C.Berndt S.I.Bézieau S.B.Bishop D.T.Boehm J.Boeing H.Boutron-Ruault M.-C.Brenner H.Brezina S.Buch S.Buchanan D.D.Burnett-Hartman A.Caan B.J.Campbell P.T.Carr P.R.Castells A.Castellví-Bel S.Chan A.T.Chang-Claude J.Chanock S.J.Curtis K.R.de la Chapelle A.Easton D.F.English D.R.Feskens E.J.M.Gala M.Gallinger S.J.Gauderman W.J.Giles G.G.Goodman P.J.Grady W.M.Grove J.S.Gsur A.Gunter M.J.Haile R.W.Hampe J.Hoffmeister M.Hopper J.L.Hsu W.-L.Huang W.-Y.Hudson T.J.Jenab M.Jenkins M.A.Joshi A.D.Keku T.O.Kooperberg C.Kühn T.Küry S.Le Marchand L.Lejbkowicz F.Li C.I.Li L.Lieb W.Lindblom A.Lindor N.M.Männistö S.Markowitz S.D.Milne R.L.Moreno L.Murphy N.Nassir R.Offit K.Ogino S.Panico S.Parfrey P.S.Pearlman R.Pharoah P.D.P.Phipps A.I.Platz E.A.Potter J.D.Prentice R.L.Qi L.Raskin L.Rennert G.Rennert H.S.Riboli E.Schafmayer C.Schoen R.E.Seminara D.Song M.Su Y.-R.Tangen C.M.Thibodeau S.N.Thomas D.C.Trichopoulou A.Ulrich C.M.Visvanathan K.Vodička P.Vodičková L.Vymetálková V.Weigl K.Weinstein S.J.White E.Wolk A.Woods M.O.Wu A.H.Abecasis G.R.Nickerson D.A.Scacheri P.C.Kundaje A.Casey G.Gruber S.B.Hsu L.Moreno V.Hayes R.B.Newcomb P.A.Peters U. Published on 2021 Metadata Gut. 70(7): 1325-1334.

Identifying novel susceptibility genes for colorectal cancer risk from a transcriptome-wide association study of 125,478 subjects.

 DepartmentDepartment of Molecular Biology of Cancer AutořiGuo X.Lin W.Wen W.Huyghe J.Bien S.Cai Q.Harrison T.Chen Z.Qu C.Bao J.Long J.Yuan Y.Wang F.Bai M.Abecasis G.R.Albanes D.Berndt S.I.Bézieau S.Bishop D.T.Brenner H.Buch S.Burnett-Hartman A.Campbell P.T.Castellví-Bel S.Chan A.T.Chang-Claude J.Chanock S.J.Cho S.H.Conti D.V.de la Chapelle A.Feskens E.J.M.Gallinger S.J.Giles G.G.Goodman P.J.Gsur A.Guinter M.Gunter M.J.Hampe J.Hampel H.Hayes R.B.Hoffmeister M.Kampman E.Kang H.M.Keku T.O.Kim H.R.Le Marchand L.Lee S.C.Li C.I.Li L.Lindblom A.Lindor N.Milne R.L.Moreno V.Murphy N.Newcomb P.A.Nickerson D.A.Offit K.Pearlman R.Pharoah P.D.P.Platz E.A.Potter J.D.Rennert G.Sakoda L.C.Schafmayer C.Schmit S.L.Schoen R.E.Schumacher F.R.Slattery M.L.Su Y.-R.Tangen C.M.Ulrich C.M.van Duijnhoven F.J.B.van Guelpen B.Visvanathan K.Vodička P.Vodičková L.Vymetálková V.Wang X.White E.Wolk A.Woods M.O.Casey G.Hsu L.Jenkins M.A.Gruber S.B.Peters U.Zheng W. Published on 2021 Metadata Gastroenterology. 160(4) 1164–1178.

Genetic variations in 3'UTRs of SMUG1 and NEIL2 genes modulate breast cancer risk, survival and therapy response.

 DepartmentDepartment of Molecular Biology of Cancer AutořiČumová A.Vymetálková V.Opattová A.Boušková V.Pardini B.Kopečkov K.Kozevnikovová R.Licková K.Ambrus M.Vodičková L.Naccarati A.Souček P.Vodička P. Published on 2021 Metadata Mutagenesis. 36(4): 269-279.

Mutational landscape of plasma cell-free DNA identifies molecular features associated with therapeutic response in patients with colon cancer. A pilot study.

 DepartmentDepartment of Molecular Biology of Cancer AutořiČervená K.Pardini B.Urbanová M.Vodenková S.Pazourková E.Veškrnová V.Levy M.Buchler T.Mokrejs M.Naccarati A.Vodička P.Vymetálková V. Published on 2021 Metadata Mutagenesis. 36(5): 358-268.

Local Immune Changes in Early Stages of Inflammation and Carcinogenesis Correlate with the Collagen Scaffold Changes of the Colon Mucosa.

 DepartmentDepartment of Molecular Biology of Cancer AutořiČaja F.Stakheev D.Chernyavskiy O.Kubinová L.Krizan J.Dvořák J.Rossmann P.Štěpánková R.Makovický P.Makovický P.Vymetálková V.Souček P.Vodička P.Vodičková L.Levý M.Vannucci L. Published on 2021 Metadata Cancers. 13(10): 2463.

Genetic variations in microRNA-binding sites of solute carrier transporter genes as predictors of clinical outcome in colorectal cancer.

 DepartmentDepartment of Molecular Biology of Cancer AutořiBendová P.Pardini B.Susová S.Rosendorf J.Levy M.Skrobánek P.Buchler T.Král J.Liska V.Vodičková L.Landi S.Souček, P.Naccarati A.Vodička P.Vymetálková V. Published on 2021 Metadata Carcinogenesis. 42(3): 378-394.

The dynamics of telomere length in primary and metastatic colorectal cancer lesions

 DepartmentDepartment of Molecular Biology of Cancer AutořiKroupa M.Kubecek O.Tomášová K.Hanák P.Krupová M.Červená K.Šišková A.Rosendorf J.Hosek P.Vodičková L.Vodička P.Liška V.John S.Vymetálková V.Petera J. Published on 2023 Metadata Sci Rep . 2023 Jun 5;13(1):9097. doi: 10.1038/s41598-023-35835-9.

Differences in genome, transcriptome, miRNAome, and methylome in synchronous and metachronous liver metastasis of colorectal cancer

 DepartmentDepartment of Molecular Biology of Cancer Department of Toxicology and Molecular Epidemiology AutořiHorák J.Kubecek O.Šišková A.Hoňková K.Chvojková I.Krupova M.Manethova M.Vodenková S.García-Mulero S.John S.Cecka F.Vodičková L.Petera J.Filip S.Vymetálková V. Published on 2023 Metadata Front Oncol . 2023 Apr 27;13:1133598. doi: 10.3389/fonc.2023.1133598. eCollection 2023.

MUC13-miRNA-4647 axis in colorectal cancer: Prospects to identifications of risk factors and clinical outcomes.

 DepartmentDepartment of Molecular Biology of Cancer AutořiSojka L.Opattová A. Bartů L.Horák J.Kořenková V.Novosadová V.Krížková V.Bruha J.Liška V.Schneiderová M.Kubecek O.Vodičková L.Urbanová M.Simsa J.Vodička P.Vymetálková V. Published on 2023 Metadata Oncology Letters. 25 (2): 72.

An investigation of DNA damage and DNA repair in chemical carcinogenesis triggered by small-molecule xenobiotics and in cancer: Thirty years with the comet assay.

 DepartmentDepartment of Molecular Biology of Cancer AutořiVodička P.Vodenková S.Horák J.Opattová A.Tomášová K.Vymetálková V.Stetina R.Hemminki K.Vodičková L. Published on 2023 Metadata Mutation Research – Genetic Toxicology and Environmental Mutagenesis. 885: 503564.

Analysis of MicroRNA Expression Changes During the Course of Therapy In Rectal Cancer Patients.

 DepartmentDepartment of Molecular Biology of Cancer AutořiČervená K.Novosadová V.Pardini B.Naccarati A.Opattová A.Horák J.Vodenková S.Buchler T.Skrobanek P.Levy M.Vodička P.Vymetálková V. Published on 2021 Metadata Front Oncol . 2021 Sep 2:11:702258. doi: 10.3389/fonc.2021.702258. eCollection 2021.

Diagnostic and prognostic impact of cell-free DNA in human cancers: Systematic review

 DepartmentDepartment of Molecular Biology of Cancer AutořiČervená K.Vodička P.Vymetálková V. Published on 2019 Metadata Mutat Res Rev Mutat Res . 2019 Jul-Sep;781:100-129. doi: 10.1016/j.mrrev.2019.05.002. Epub 2019 May 11.