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Auditory Neuroscience

Research department

Group photo of the Department of Auditory Neuroscience team

The main task of our department is to study the mechanisms of audiological disorders, which significantly reduce the quality of life of people, especially the aging population. We mainly use animal models of the disorders, in which we combine interdisciplinary experimental approaches covering levels from in vitro to in vivo. We also carry out experimental studies in human volunteers using audiometric methods combined with fMRI measurements.

Rostislav Tureček

Head of the Department
Rostislav Tureček, Ph.D.

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Assoc. Prof. Zbyněk Bureš, Ph.D.

Jana Svobodová Burianová, Ph.D.

Minseok Kang, Ph.D.

Oliver Profant, M.D., Ph.D.

Kateryna Pysanenko, Ph.D.

Natalia Rybalková, Ph.D.

Prof. Josef Syka, M.D., Sc.D.

Assoc. Prof. Daniel Šuta, Ph.D.

Rostislav Tureček, Ph.D.

PhD Students

Dora Čapková, M.D.

Jakub Fuksa, M.D.

Adolf Melichar, M.Sc.

Pre-Grad Students

Jana Dittrichová, B.Sc.

Laboratory Technicians

Štěpánka Suchánková, B.Sc.

Research Assistants and Technicians

Milan Jilek, M.Sc.

Jan Setnička

Important results

Important results in 2022

ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization

It was discovered that the transcription factor ISL1 regulates the molecular and cellular features of auditory neurons. In the mutant mice with selective absence of Isl1, spiral ganglion neurons migrate into the central cochlea and the cochlear wiring is profoundly reduced and disrupted. The central axons of Isl1 mutants lose their topographic projections and segregation at the cochlear nucleus. Our findings show that ISL1 is one of the obligatory factors required to sculpt auditory structural and functional tonotopic maps.

Kolážový snímek s grafy a výsledky charakteristiky neuronů colliculus inferior. Detailní popis naleznete pod obrázkem.

Characteristics of inferior colliculus neurons in control mice and in mice with conditionally deleted Isl1 (Isl1CKO) mice. Characteristics of inferior colliculus (IC) neurons are affected in conditionally deleted Isl1 (Isl1CKO) mice.



Filová, I., Pysanenko, K., Tavakoli, M., Vochyanova, S., Dvořáková, M., Bohuslavová, R., Smolík, O., Fabriciová, V., Hrabalová, P., Benešová, Š., Valihrach, L., Černý, J., Yamoah, E.N., Syka, J., Fritzsch, B., Pavlinková, G.: (2022) ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization. Proceedings of the National Academy of Sciences of the United States of America. 119(37): e2207433119.