Important results in 2022
ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization
It was discovered that the transcription factor ISL1 regulates the molecular and cellular features of auditory neurons. In the mutant mice with selective absence of Isl1, spiral ganglion neurons migrate into the central cochlea and the cochlear wiring is profoundly reduced and disrupted. The central axons of Isl1 mutants lose their topographic projections and segregation at the cochlear nucleus. Our findings show that ISL1 is one of the obligatory factors required to sculpt auditory structural and functional tonotopic maps.
Filová, I., Pysanenko, K., Tavakoli, M., Vochyanova, S., Dvořáková, M., Bohuslavová, R., Smolík, O., Fabriciová, V., Hrabalová, P., Benešová, Š., Valihrach, L., Černý, J., Yamoah, E.N., Syka, J., Fritzsch, B., Pavlinková, G.: (2022) ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization. Proceedings of the National Academy of Sciences of the United States of America. 119(37): e2207433119.