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Auditory Neuroscience

Research department

Group photo of the Department of Auditory Neuroscience team

The main task of our department is to study the mechanisms of audiological disorders, which significantly reduce the quality of life of people, especially the aging population. We mainly use animal models of the disorders, in which we combine interdisciplinary experimental approaches covering levels from in vitro to in vivo. We also carry out experimental studies in human volunteers using audiometric methods combined with fMRI measurements.

Rostislav Tureček

Head of the Department
Rostislav Tureček, Ph.D.

Telefonní číslo +420 241 062 748
Mailová adresa rostislav.turecek@iem.cas.cz
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Researchers

Assoc. Prof. Zbyněk Bureš, Ph.D.

Jana Svobodová Burianová, Ph.D.

Minseok Kang, Ph.D.

Assoc. Prof. Oliver Profant, M.D., Ph.D.

Kateryna Pysanenko, Ph.D.

Natalia Rybalková, Ph.D.

Prof. Josef Syka, M.D., Sc.D.

Assoc. Prof. Daniel Šuta, Ph.D.

Rostislav Tureček, Ph.D.

PhD Students

Dora Čapková, M.D.

Jakub Fuksa, M.D.

Adolf Melichar, M.Sc.

Pre-Grad Students

Jana Dittrichová, B.Sc.

Laboratory Technicians

Štěpánka Suchánková, B.Sc.

Research Assistants and Technicians

Milan Jilek, M.Sc.

Jan Setnička

Important results


Important results in 2022

ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization

It was discovered that the transcription factor ISL1 regulates the molecular and cellular features of auditory neurons. In the mutant mice with selective absence of Isl1, spiral ganglion neurons migrate into the central cochlea and the cochlear wiring is profoundly reduced and disrupted. The central axons of Isl1 mutants lose their topographic projections and segregation at the cochlear nucleus. Our findings show that ISL1 is one of the obligatory factors required to sculpt auditory structural and functional tonotopic maps.

Kolážový snímek s grafy a výsledky charakteristiky neuronů colliculus inferior. Detailní popis naleznete pod obrázkem.

Characteristics of inferior colliculus neurons in control mice and in mice with conditionally deleted Isl1 (Isl1CKO) mice. Characteristics of inferior colliculus (IC) neurons are affected in conditionally deleted Isl1 (Isl1CKO) mice.

 

Publication:

Filová, I., Pysanenko, K., Tavakoli, M., Vochyanova, S., Dvořáková, M., Bohuslavová, R., Smolík, O., Fabriciová, V., Hrabalová, P., Benešová, Š., Valihrach, L., Černý, J., Yamoah, E.N., Syka, J., Fritzsch, B., Pavlinková, G.: (2022) ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization. Proceedings of the National Academy of Sciences of the United States of America. 119(37): e2207433119.


Projects

Provider

Year

1. 5. 2020 – 31. 12. 2024

Novel diagnostic methods in examination of age related changes of the auditory system.
1. 1. 2021 – 30. 6. 2024

The role of GABAB receptor-associated KCTD16 proteins in the sensory nervous system
1. 1. 2023 – 31. 12. 2025

Transcriptional and epigenetic regulation of auditory neuron development

Publications

The Influence of Asymmetric Hearing Loss on Peripheral and Central Auditory Processing Abilities in Patients With Vestibular Schwannoma

 DepartmentDepartment of Auditory Neuroscience AutořiSvobodová V.Profant O.Syka J.Tóthová D.Bureš Z. Published on 2024 Metadata Ear Hear . 2024 Jul 15. doi: 10.1097/AUD.0000000000001555. Online ahead of print.

The effect of aging, hearing loss, and tinnitus on white matter in the human auditory system revealed with fixel-based analysis

 DepartmentDepartment of Auditory Neuroscience AutořiSvobodová V.Profant O.Škoch A.Tintěra J.Tóthová D.Chovanec M.Čapková D.Syka J. Published on 2024 Metadata Front Aging Neurosci . 2024 Jan 9:15:1283660. doi: 10.3389/fnagi.2023.1283660. eCollection 2023.

Mice prone to tinnitus after acoustic trauma show increased pre-exposure sensitivity to background noise

 DepartmentDepartment of Auditory Neuroscience AutořiRybalko N.Suchánková S.Bureš Z.Jovanovič N.Melichar A.Profant O.Tureček R. Published on 2023 Metadata Front Behav Neurosci . 2023 Dec 8:17:1321277. doi: 10.3389/fnbeh.2023.1321277. eCollection 2023.

Deficient central mechanisms in tinnitus: Exploring the impact on speech comprehension and executive functions

 DepartmentDepartment of Auditory Neuroscience AutořiSommerhalder N.Neff P.Bureš Z.Profant O.Kleinjung T.Meyer M. Published on 2023 Metadata Hear Res . 2023 Dec:440:108914. doi: 10.1016/j.heares.2023.108914. Epub 2023 Nov 10.

The role of GABAB receptors in the subcortical pathways of the mammalian auditory system.

 DepartmentDepartment of Auditory Neuroscience AutořiTureček R.Melichar A.Králíková M.Hrušková B. Published on 2023 Metadata Frontiers in Endocrinology.14 : 1195038.

Altered hearing function in mice with implanted cranial windows.

 DepartmentDepartment of Auditory Neuroscience AutořiJovanovič N.Suchánková S.Kang M.Melichar A.Bureš Z.Tureček R. Published on 2023 Metadata Neuroscience Letters. 792: 136969.

Head-shaking-induced nystagmus reflects dynamic vestibular compensation: A 2-year follow-up study.

 DepartmentDepartment of Auditory Neuroscience AutořiStriteska M.Valis M.Chrobok V.Profant O.Califano L.Syba J.Trnková K.Kremlacek J.Chovanec M. Published on 2022 Metadata Frontiers in Neurology. 13: 949696.

Early disruption of photoreceptor cell architecture and loss of vision in a humanized pig model of usher syndromes.

 DepartmentDepartment of Auditory Neuroscience AutořiGrotz S.Schaefer J.Wunderlich K.A.Ellederova Z.Auch H.Baehr A.Runa-Vochozkova P.Fadl J.Arnold V.Ardan T.Veith M.Santamaria G.Dhom G.Hitzl W.Kessler B.Eckardt Ch.Klein J.Brymova A.Linnert J.Kurome M.Zakharchenko V.Fischer A.Blutke A.Suchánková S.Popelář J.Rodriguez-Bocanegra E.Dlugaiczyk J.Straka H.May-Simera H.Wang W.Laugwitz K.L.Vandenberghe L.H.Wolf E.Nagel-Wolfrum K.Peters T.Motlik J.Fischer M.D.Wolfrum U.Klymiuk N. Published on 2022 Metadata EMBO Molecular Medicine. 14(4):e14817.

Estimated Vestibulogram (EVEST) for Effective Vestibular Assessment.

 DepartmentDepartment of Auditory Neuroscience AutořiStriteska M.Skoloudik L.Valis M.Mejzlik J.Trnková K.Chovanec M.Profant O.Chrobok V.Kremlacek J. Published on 2021 Metadata Biomed Research International. 8845943.

Decision making on vestibular schwannoma treatment: predictions based on machine-learning analysis.

 DepartmentDepartment of Auditory Neuroscience AutořiProfant O.Bureš Z.Balogová Z.Betka J.Fík Z.Chovanec M.Voráček J. Published on 2021 Metadata Scientific Reports. 11: 8376.

Binocular video head impulse test: Normative data study

 DepartmentDepartment of Auditory Neuroscience Autoři Striteská M.Chovanec M.Steinmetzer T.Chrobok V.Profant O.Schneider E.Kremlacek J.Valis M. Published on 2023 Metadata Frontiers in Neurology. 14: 1153102.

Differences in auditory temporal processing in the left and right auditory cortices of the rat.

 DepartmentDepartment of Auditory Neuroscience AutořiBureš Z.Pysanenko K.Syka J. Published on 2023 Metadata Hear Res . 2023 Mar 15;430:108708. doi: 10.1016/j.heares.2023.108708. Epub 2023 Feb 2.

Ablation of Gabra5 Influences Corticosterone Levels and Anxiety-like Behavior in Mice.

 DepartmentDepartment of Auditory Neuroscience AutořiSyding L. A.Kubik-Zahorodna A.Reguera D. P.Nickl P.Hrušková B.Králíková M.Kopkanová J.Novosadová V.Kašpárek P.Procházka J.Rozman J.Tureček R.Sedláček R. Published on 2023 Metadata Genes. 14(2): 285.

Functional changes in the auditory cortex and associated regions caused by different acoustic stimuli in patients with presbycusis and tinnitus.

 DepartmentDepartment of Auditory Neuroscience AutořiFuksa J.Profant O.Tintěra J.Svobodová V.Tóthová D.Skoch A.Syka J. Published on 2022 Metadata Frontiers in Neuroscience. 16: 921873.

ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization.

 DepartmentDepartment of Auditory Neuroscience AutořiFilová I.Pysanenko K.Tavakoli M.Vochyanova S.Dvořáková M.Bohuslavová R.Smolík O.Fabriciová V.Hrabalová P.Benešová Š.Valihrach L.Černý J.Yamoah E.N.Syka J.Fritzsch B.Pavlinková G. Published on 2022 Metadata Proceedings of the National Academy of Sciences of the United States of America. 119(37): e2207433119.

The influence of developmental noise exposure on the temporal processing of acoustical signals in the auditory cortex of rats.

 DepartmentDepartment of Auditory Neuroscience AutořiBureš Z.Pysanenko K.Syka J. Published on 2021 Metadata Hearing Research. 409: 108306.

Heterogeneous Associative Plasticity in the Auditory Cortex Induced by Fear Learning – Novel Insight Into the Classical Conditioning Paradigm.

 DepartmentDepartment of Auditory Neuroscience AutořiZelenka O.Novák O.Brunová A.Syka J. Published on 2021 Metadata Physiological Research. 70(3): 447-460.

Overexpression of Isl1 under the Pax2 Promoter, Leads to Impaired Sound Processing and Increased Inhibition in the Inferior Colliculus.

 DepartmentDepartment of Auditory Neuroscience AutořiChumak T.Filová I.Bureš Z.Popelář J.Pavlínková G.Syka J. Published on 2021 Metadata International Journal of Molecular Sciences. 22(9): 4507

Acoustically Enriched Environment during the Critical Period of Postnatal Development Positively Modulates Gap Detection and Frequency Discrimination Abilities in Adult Rats.

 DepartmentDepartment of Auditory Neuroscience AutořiPysanenko K.Rybalko N.Bureš Z.Šuta D.Lindovský J.Syka J. Published on 2021 Metadata Neural Plasticity. 6611922.

Effect of Kv3 channel modulators on auditory temporal resolution in aged Fischer 344 rats.

 DepartmentDepartment of Auditory Neuroscience AutořiRybalko N.Popelář J.Šuta D.Svobodová Burianová J.Alvaro, G.S.Large, CH.Syka J. Published on 2020 Metadata Hearing Research. 401: 108139.

The influence of aging, hearing and tinnitus on the morphology of cortical grey matter, amygdala and hippocampus.

 DepartmentDepartment of Auditory Neuroscience AutořiProfant O.Škoch A.Tintěra J.Svobodová V.Svobodová Burianová J.Syka J. Published on 2020 Metadata Frontiers in Aging Neuroscience. 409: 108306

Age-related changes in the temporal processing of acoustical signals in the auditory cortex of rats.

 DepartmentDepartment of Auditory Neuroscience AutořiBureš Z.Pysanenko K.Syka J. Published on 2020 Metadata Hearing Research. 402(SI): 108025.

Speech Comprehension and Its Relation to Other Auditory Parameters in Elderly Patients With Tinnitus.

 DepartmentDepartment of Auditory Neuroscience AutořiBureš Z.Profant O.Svobodová V.Tóthová D.Vencovský V.Syka J. Published on 2019 Metadata Frontiers in Aging Neuroscience. 11: 219.

Bright and photostable chemigenetic indicators for extended in vivo voltage imaging.

 DepartmentDepartment of Auditory Neuroscience AutořiAbdelfattah A.S.Kawashima T.Singh A.Novák O.Liu H.Shuai Y.C.Huang Y.C.Campagnola L.Seeman S.C.Yu J.Zheng J.H.Grimm J.B.Patel R.Friedrich J.Mensh B.D.Paninski L.Macklin J.J.Murphy G.J.Podgorski K.Lin B.J.Chen T.W.Turner G.C.Liu Z.Koyama M.Svoboda K.Ahrens M.B.Lavis L.D.Schreiter E.R. Published on 2019 Metadata Science. 365(6454): 699-704.

Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing

 DepartmentDepartment of Auditory Neuroscience AutořiDinamarca M.C.Raveh A.Schneider A.Fritzius T.Fruh S.Rem P.D.Stawarski M.Lalanne T.Tureček R.Choo M. Published on 2019 Metadata Nat Commun . 2019 Mar 22;10(1):1331. doi: 10.1038/s41467-019-09164-3.

Collaborators