Compromised Astrocyte Swelling/Volume Regulation in the Hippocampus of the Triple Transgenic Mouse Model of Alzheimer's Disease
We have shown here that APP Swedish, MAPT P301L, and PSEN1 M146V mutations in the murine model of Alzheimer’s disease lead to the structural changes in the extracellular space differing from those observed in physiological aging. We suggest that they are caused by cell atrophy on the one hand and shifts and changes in the ECS content including an increase of the diffusion obstacles (barriers) on the other.
Turečková, J., Kamenická, M., Koleničová, D., Filipi, T., Heřmanová, Z., Kriška, J., Mészárošová, L., Pukajová, B., Valihrach, L., Androvič, P., Žucha, D., Chmelová, M., Vargová, L., Anděrová, M.: (2022) Compromised Astrocyte Swelling/Volume Regulation in the Hippocampus of the Triple Transgenic Mouse Model of Alzheimer’s Disease. Frontiers in Aging Neuroscience. 13: 783120.