Important Results
Compromised Astrocyte Swelling/Volume Regulation in the Hippocampus of the Triple Transgenic Mouse Model of Alzheimer's Disease
We have shown here that APP Swedish, MAPT P301L, and PSEN1 M146V mutations in the murine model of Alzheimer’s disease lead to the structural changes in the extracellular space differing from those observed in physiological aging. We suggest that they are caused by cell atrophy on the one hand and shifts and changes in the ECS content including an increase of the diffusion obstacles (barriers) on the other.
Scheme describing the major changes in astrocyte channel/transporter expression and extracellular matrix structure resulting in the altered ability of astrocytes to uptake ions and neurotransmitters from the extracellular space (ECS) and regulate their cell volume. Schematic illustration of astrocyte morphological changes, extracellular matrix structure, and changes in astrocytic channel and transporter expression in Ctrl (A) and triple transgenic (3xTgAD) mouse models of Alzheimer's disease (B).
Publication:
Turečková, J., Kamenická, M., Koleničová, D., Filipi, T., Heřmanová, Z., Kriška, J., Mészárošová, L., Pukajová, B., Valihrach, L., Androvič, P., Žucha, D., Chmelová, M., Vargová, L., Anděrová, M.: (2022) Compromised Astrocyte Swelling/Volume Regulation in the Hippocampus of the Triple Transgenic Mouse Model of Alzheimer’s Disease. Frontiers in Aging Neuroscience. 13: 783120.
2024
Nat. Nanotechnol. (2024). https://doi.org/10.1038/s41565-024-01711-4
