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Cellular Neurophysiology

Research Department

Group photo of the Department of Cellular Neurophysiology team

The Department is focused on research of the morphological and electrophysiological properties of glial cells. We investigate their functions in the pathophysiology of central nervous system disorders, such as focal cerebral ischemia, amyotrophic lateral sclerosis, Alzheimer's disease, schizophrenia, and tumorigenesis. We focus primarily on astrocytes and polydendrocytes (also known as NG2 glia). Using genetically modified mouse strains and new technologies specifically designed for the research of glial cells, we study the role of ion and water channels in cerebral edema and post-ischemic regeneration. In addition, we investigate the role of Wnt signaling in neurogenesis and gliogenesis following ischemic brain injury at the single-cell level.

Miroslava Anděrová

Head of the Department
Miroslava Anděrová, Ph.D.

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Jana Turečková, Ph.D.


Miroslava Anděrová, Ph.D.

Martina Chmelová, Ph.D.

Assoc. Prof. Daniel Jirák, Ph.D.

Ján Kriška, Ph.D.

Jana Turečková, Ph.D.

Ing. Lukáš Valihrach, Ph.D.

Assoc. Prof. Lýdia Vargová, M.D., Ph.D.

PhD Students

Tereza Filipi, M.Sc.

Alice Foltýnová, M.Sc.

Zuzana Heřmanová, M.Sc.

Tomáš Knotek, M.Sc.

Valeria Marchetti, M.Sc.

Ondřej Vaňátko, M.Sc.

Natalia Ziólkowska, M.Sc.

Natália Sirotová, MSc.

Pre-Grad Students

Monika Kubísková, B.Sc.

Laboratory Technicians

Markéta Hemerová, M.Sc.

Helena Pavlíková

Important Results

Compromised Astrocyte Swelling/Volume Regulation in the Hippocampus of the Triple Transgenic Mouse Model of Alzheimer's Disease

We have shown here that APP Swedish, MAPT P301L, and PSEN1 M146V mutations in the murine model of Alzheimer’s disease lead to the structural changes in the extracellular space differing from those observed in physiological aging. We suggest that they are caused by cell atrophy on the one hand and shifts and changes in the ECS content including an increase of the diffusion obstacles (barriers) on the other.

Schéma popisující hlavní změny v expresi astrocytárních kanálů/transportérů a struktuře extracelulární matrix. Detailní popis naleznete pod obrázkem.

Scheme describing the major changes in astrocyte channel/transporter expression and extracellular matrix structure resulting in the altered ability of astrocytes to uptake ions and neurotransmitters from the extracellular space (ECS) and regulate their cell volume. Schematic illustration of astrocyte morphological changes, extracellular matrix structure, and changes in astrocytic channel and transporter expression in Ctrl (A) and triple transgenic (3xTgAD) mouse models of Alzheimer's disease (B).



Turečková, J., Kamenická, M., Koleničová, D., Filipi, T., Heřmanová, Z., Kriška, J., Mészárošová, L., Pukajová, B., Valihrach, L., Androvič, P., Žucha, D., Chmelová, M., Vargová, L., Anděrová, M.: (2022) Compromised Astrocyte Swelling/Volume Regulation in the Hippocampus of the Triple Transgenic Mouse Model of Alzheimer’s Disease. Frontiers in Aging Neuroscience. 13: 783120.