Research Projects
Our research projects cover a wide range of biomedical fields. See an overview of all our current projects.
List of Projects
2026-2030
Mechanisms of R-loop-mediated DNA Replication Stress: From Basic Principles to Cancer Therapy
1. 3. 2026 – 28. 2. 2029
The role of GABAergic inhibition in mechanisms of impaired processing of complex sounds in sensorineural hearing loss
Program: INTEREXCELLENCE II – INTERACTION
2025–2027
The impact of microbiota transfer on microglia-mediated inflammation in ALS
2025–2027
Reprogramming of glial cells into interneurons using synthetic mRNA
2025–2027
Function of mTOR signaling pathway in NG2 glia after ischemic brain injury
2026–2028
Impact of mTOR signaling modulation in NG2-expressing cells on the neuroregeneration after ischemic brain injury
2025–2027
Extracellular vesicles as activators of Wnt/b-catenin signaling pathway in blood-brain barrier after ischemia
2024–2027
Personalized bone reconstruction with fast-osseointegrative and antibacterial titanium implants after osteosarcoma surgical resection
2024–2027
Prevention and treatment of the orthopedic infections with injectable resorbable bone substitute gradually releasing pathogen-specific antimicrobial compounds
2024–2027
Nanofibrous surgical threads for delivery of bioactive and antimicrobial substances
3/2025–12/2028
Treatment of spinal cord injury via targeted inhibition of the inflammasome with gene therapy stimulation of motor pathway axon regeneration
Program: INTEREXCELLENCE II – INTERACTION
2025–2029
Real-world emission Experiments and comprehensive Assessment of Low-carbon fuels: towards Clean Hard-to-Electrify traffic Modes
Mezinárodní konsorcium vedené koordinátorem Tampereen Korkeakoulusäätiö Sr – Tamperskou univerzitou ve Finsku.
An international consortium led by the coordinator Tampereen Korkeakoulusäätiö Sr – Tampere University in Finland.
1. 5. 2025 – 31. 12. 2028
Role of kynurenines in the pathophysiology of the inflammatory response and vasospasm in patients with aneurysmal subarachnoid hemorrhage
2025–2027
A study of epigenetic memory as a tool to reduce negative impacts of exposure to nanoparticles
1. 4. 2025 – 31. 3. 2028
Advanced Glycomimetics for the Treatment of Age-Related Neurodegenerative Disorders: A Comprehensive Biological Study
2025–2027
The role of auxiliary subunits of GABAB receptors in pathological conditions of the mouse sensory nervous system
1. 3. 2024 – 31. 12. 2026
Innovative use of nanofibers and 3D bioprinting for regenerative medicine
2024–2028
Mushrooms – New threats and opportunities
1. 5. 2024 – 31. 12. 2027
The predictive value of circulating biomarkers for complete pathological response after total neoadjuvant radiochemotherapy of rectal cancer
Hlavní řešitel: Radmila Lemstrová – Univerzita Palackého v Olomouci
2024–2026
Renewal and modernization of the national infrastructure for translational medicine EATRIS-CZ
2024–2026
Modernization of Czech-BioImaging large research infrastructure
2024–2026
Upgrade and modernization of the LRI Nanomaterials and nanotechnologies for environmental protection and a sustainable future
2024–2026
Impact of Wnt signaling modulation on the heterogeneity and functions of NG2-expressing cells in the adult cortex following focal brain ischemia
2024–2026
Novel open-channel blockers of NMDA receptors with enhanced membrane-to-channel inhibition
2024–2026
Reconstruction of the spinal cord sensory pathway using an integrin approach to axon regeneration.
1. 5. 2020 – 31. 12. 2024
Novel diagnostic methods in examination of age related changes of the auditory system.
1. 5. 2020 – 31. 12. 2023
Dually acting cognitive enhancers for palliative treatment of Alzheimer´s disease
1. 5. 2021 – 31. 12. 2024
Monitoring of serum biomarkers in patients with acute spinal cord injury
1. 5. 2021 – 31. 12. 2024
Telomere homeostasis as potential biomerker of risk, prognosis and progression in gyneacologic tumours
1. 5. 2021 – 31. 12. 2024
Concept of liquid biopsy in mapping of microRNA and oncogenicKRAS mutations for early diagnosis and risk assessment of pancreatic cancer
1. 5. 2021 – 31. 12. 2024
Tumor cell and mutational landscape in colorectal cancer development
1. 5. 2022 – 31. 12. 2026
Evolution of genomic instability and disruption of telomere integrity in colorectal cancer
1. 5. 2022 – 31. 12. 2026
Significance of mitochondrial DNA in colorectal cancer
1. 5. 2022 – 31. 12. 2025
Blood flow modelling in intracranial vessels in relationship to endothelium changes and development of intracranial aneurysms
1. 5. 2023 – 31. 12. 2026
Galectin-positive glioblastoma exosomes: new biomarkers and targets for glycoanotherapeutics
1. 1. 2020 – 30. 6. 2023
Microbial metabolites and dietary factors influencing genome and epigenome in colorectal cancer development
1. 1. 2021 – 31. 12. 2023
Protective coatings against dissolution/disintegration of upcorventing lanthanide-based nanoparticles in biological media
1. 1. 2021 – 30. 6. 2024
The role of GABAB receptor-associated KCTD16 proteins in the sensory nervous system
1. 1. 2021 – 31. 12. 2023
The impact of metal nanoparticles on properties and functions of stem cells: an in vitro and in vivo study
1. 7. 2021 – 30. 6. 2024
Telomere homeostasis from colorectal adenoma to metastatic cancer
1. 1. 2021 – 31. 12. 2025
Horizontal transfer of mitochondria in cancer biology
1. 1. 2022 – 31. 12. 2024
Polymer-based drug delivery vectors targeting stemness and metabolism of glioblastoma cells
1. 1. 2022 – 31. 12. 2024
The role of Meis transcription factors in mesenchymal condensations during formation of the cranium
1. 1. 2022 – 31. 12. 2024
Non-invasive detection of circulating mRNA markers in diseases of the colon and rectum
1. 1. 2022 – 31. 12. 2024
The concept of rationally designed triple agents against Alzheimer's disease
1. 4. 2022 – 31. 12. 2024
Transcriptome changes and genome integrity in human subjects acutely and chronically exposed to nanoparticles
1. 4. 2022 – 31. 12. 2024
Metabolic reprogramming of mesenchymal stromal cells for regenerative medicine applications
1. 3. 2022 – 28. 2. 2025
Molecular and functional analysis of the nucleolus in 3D genome organization during early embryo development
GAČR ve spolupráci Swiss National Science Foundation
1. 1. 2023 – 31. 12. 2025
Modulation of extracellular matrix to enhance neuroplasticity for the rescue of age-related memory deficits
1. 1. 2023 – 31. 12. 2025
Transcriptional and epigenetic regulation of auditory neuron development
2022–2025
National institute for cancer research
2022–2024
Hyperactive PI3 Kinase and activated integrin for corticospinal regeneration
IRP – International Foundation for Research in Paraplegia
2022–2023
Reconstruction of the SC sensory pathway
IRP – International Foundation for Research in Paraplegia
2021–2024
Targeted and Improved Alzheimer's Disease Drug Development
Hlavním příjemcem je FN Hradec Králové, dalšími partnery jsou Bioinova, a.s. a University of Oslo
2018–2023
Healthy Aging in Industrial Environment
ÚEM je v projektu partnerem Ostravské univerzity
2017–2023
Center of Reconstructive Neuroscience
1. 5. 2019 – 30. 4. 2023
Transport derived Ultrafines and the Brain Effects
Mezinárodní konsorcium vedené koordinátorem ITA-SUOMEN YLIOPISTO – University of Eastern Finland
2023–2025
Particle emission prevention and impact: from real-world emissions of traffic to secondary PM of urban air
2023–2028
Excellence in Regenerative Medicine
2023–2026
Nanomaterials and nanotechnologies for protection of the environment and sustainable future
2022–2024
The role of sEVs derived from stem cell culture medium in the regeneration of spinal cord injury in vitro
2022–2025
Multifunctional nanofiber membranes as CBRN Shield for next generation defence and civil application
2022–2026
Towards Precision Medicine and Gene Therapy
2022–2024
Regeneration of sensory axons after spinal cord injury
2022–2024
The effect of 3D microenvironment on paracrine activity of multipotent mesenchymal stromal cells
2021–2023
Axon regeneration induced by blocking inhibitors produced by glial cells combined with expression of activated integrin
2021–2023
The role of the transcription factor Meis1 during craniofacial development in zebrafish (Danio rerio)
2021–2024
Genome stability in mammalian oocytes and somatic cells
2020–2023
Novel neuroprotective compounds based on NMDA receptor antagonism and cholinergic stimulation
1. 5. 2019 – 31. 12. 2023