Two different phospholipases C, Isc1 and Pgc1, cooperate to regulate mitochondrial function
Mitochondria are constantly adapting to changes in nutrient availability and environmental stresses. We have proposed a model in which this adaptation is mediated by lipids. Specifically, we have shown that mitochondrial phospholipids regulate cellular sphingolipid biosynthesis and vice versa. In this way, the cell is able to coordinate mitochondrial structure and performance with the actual needs of the cellular metabolism. This seems to be a universally applicable principle of cellular regulation.
Balazova, M., Vesela, P., Babelova, L., Durisova, I., Kanovicova, P., Zahumensky, J., Malinsky, J.: (2022) Two different phospholipases C, Isc1 and Pgc1, cooperate to regulate mitochondrial function. Microbiology Spectrum. 10(6): e02489-22.