Department

Department of Neurochemistry

Research Department

Head of the Department

Martin Horák

Education / Academic Qualifications

  • 2019

    Ph.D. / First Faculty of Medicine, Charles University in Prague / Medical Biophysics

  • 2012

    Ing. / Faculty of Electrical Engineering, Czech Technical University in Prague / Biomedical Engineering

Publications

Subunit-Dependent Surface Mobility and Localization of NMDA Receptors in Hippocampal Neurons Measured Using Nanobody Probes

 DepartmentDepartment of Neurochemistry AutořiKortus S.Řeháková K.Klima M.Kolcheva M.Ladislav M.Langore E.Baráčková P.Netolický J.Misiachna A.Hemelíková K.Humpolickova J.Chalupska D.Silhan J.Kaniaková M.Hrčka Krausová B.Boura E.Zapotocky M.Horák M. Published on 2023 Metadata J Neurosci. 2023 Jun 28;43(26):4755-4774. doi: 10.1523/JNEUROSCI.2014-22.2023. Epub 2023 Jun 7.

Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists.

 DepartmentDepartment of Neurochemistry AutořiKonečný J.Misiachna A.Hrabinová M.Pulkrábková L.Benková M.Prchal L.Kučera T.Kobrlová T.Finger V.Kolcheva M.Kortus S.Jun D.Valko M.Horák M.Soukup O.Korábečný J. Published on 2020 Metadata Biomolecules. 11(1): 3.

Specific pathogenic mutations in the M3 domain of the GluN1 subunit regulate the surface delivery and pharmacological sensitivity of NMDA receptors.

 DepartmentDepartment of Neurochemistry AutořiKolcheva M.Kortus S.Hrčka Krausová B.Baráčková P.Misiachna A.Danačíková Š.Kaniaková M.Hemelíková K.Hotovec M.Řeháková K.Horák M. Published on 2021 Metadata Neuropharmacology. 189: 108528.

Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors.

 DepartmentDepartment of Neurochemistry AutořiGorecki L.Misiachna A.Damborský J.Doležal R.Korábečný J.Čejková L.Hakenová K.Chvojková M.Zdarová Karasová J.Prchal L.Novák M.Kolcheva M.Kortus S.Kortus Š.Valeš K.Horák M.Soukup O. Published on 2021 Metadata European Journal of Medicinal Chemistry. 219: 113434.

The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors.

 DepartmentDepartment of Neurochemistry AutořiKolcheva M.Ladislav M.Netolický J.Kortus S.Řeháková K.Hrčka Krausová B.Hemelíková K.Misiachna A.Kádková A.Klíma M.Chalupská D.Horák M. Published on 2023 Metadata Neuropharmacology. 222: 109297.