Department

Department of Genetic Toxicology and Epigenetics

Research Department

Head of the Department

Jan Topinka

Publications

Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment

 DepartmentDepartment of Genetic Toxicology and Epigenetics AutořiMussalo L.Avesani S.Shahbaz M. A.Závodná T.Saveleva L.Järvinen A.Lampinen R.Belaya I.Krejčík Z.Ivanova M.Hakkarainen H.Kalapudas J.Penttilä E.Löppönen H.Koivisto A. M.Malm T.Topinka J.Giugno R.Aakko-Saksa P.Chew S.Rönkkö T.Jalava P.Kanninen K. M. Published on 2023 Metadata Sci Total Environ . 2023 Sep 13;905:167038. doi: 10.1016/j.scitotenv.2023.167038. Online ahead of print.

Lactose-Functionalized Carbosilane Glycodendrimers Are Highly Potent Multivalent Ligands for Galectin-9 Binding: Increased Glycan Affinity to Galectins Correlates with Aggregation Behavior

 DepartmentDepartment of Genetic Toxicology and Epigenetics AutořiMüllerová M.Hovorková M.Závodná T.Červenková Štastná L.Krupková A.Hamala V.Nováková K.Topinka J.Bojarová P.Strašák T. Published on 2023 Metadata Biomacromolecules . 2023 Sep 8. doi: 10.1021/acs.biomac.3c00426. Online ahead of print.

High aspect ratio nanomaterial-induced macrophage polarization is mediated by changes in miRNA levels.

 DepartmentDepartment of Genetic Toxicology and Epigenetics AutořiErdem J. S.Závodná T.Ervik T. K.Skare O.Hron T.Anmarkrud K. H.Kusnierczyk A.Catalan J.Ellingsen D. G.Topinka J.Zienolddiny-Narui S. Published on 2023 Metadata Frontiers in Immunology. 14: 1111123.

Biometal Dyshomeostasis in Olfactory Mucosa of Alzheimer's Disease Patients.

 DepartmentDepartment of Genetic Toxicology and Epigenetics AutořiLampinen R.Gorova V.Avesani S.Liddell J.Penttila E.Závodná T.Krejčík Z.Lehtola J.M.Saari T.Kalapudas J.Hannonen S.Lopponen H.Topinka J.Topinka J.Koivisto A.M.White A.R.Giugno R.Kanninen K.M. Published on 2022 Metadata International Journal of Molecular Sciences. 23(8): 4123.

An approach to classifying occupational exposures to endocrine disrupting chemicals by sex hormone function using an expert judgment process.

 DepartmentDepartment of Genetic Toxicology and Epigenetics AutořiPřichystalová R.Caron-Beaudoin E.Richardson l.Dirkx E.Amadou A.Závodná T.Cihak R.Cogliano V.Hynes J.Pelland-St-Pierre L.Verner M.A.van Tongeren M.Ho V. Published on 2021 Metadata Journal of Exposure Science and Environmental Epidemiology. 07/20.

Transcription profiles in BEAS-2B cells exposed to organic extracts from particulate emissions produced by a port-fuel injection vehicle, fueled with conventional fossil gasoline and gasoline-ethanol blend.

 DepartmentDepartment of Genetic Toxicology and Epigenetics Department of Nanotoxicology and Molecular Epidemiology AutořiLíbalová H.Závodná T.Vrbová K.Sikorová J.Vojtíšek-Lom M.Beránek V.Pechout M.Kléma J.Ciganek M.Machala M.Neca J.Rössner P.Topinka J. Published on 2021 Metadata Mutation Research – Genetic Toxicology and Environmental Mutagenesis. 872: 503414.

Testing Strategies of the In Vitro Micronucleus Assay for the Genotoxicity Assessment of Nanomaterials in BEAS-2B Cells.

 DepartmentDepartment of Nanotoxicology and Molecular Epidemiology Department of Genetic Toxicology and Epigenetics AutořiČervená T.Rössnerová A.Závodná T.Sikorová J.Vrbová K.Milcová A.Topinka J.Rössner P. Published on 2021 Metadata Nanomaterials. 11(8):1929.

Molecular Responses in THP-1 Macrophage-Like Cells Exposed to Diverse Nanoparticles.

 DepartmentDepartment of Genetic Toxicology and Epigenetics Department of Nanotoxicology and Molecular Epidemiology AutořiZávodná T.Javorková E.Vrbová K.Zajícová A.Holáň V.Pinkas D.Philimonenko V.Sikorová J.Kléma J.Topinka J.Rössner P. Published on 2019 Metadata Nanomaterials. 9(5): 687.

Nano-TiO2 stability in medium and size as important factors of toxicity in macrophage-like cells.

 DepartmentDepartment of Genetic Toxicology and Epigenetics Department of Nanotoxicology and Molecular Epidemiology AutořiZávodná T.Sikorová J.Milcová A.Vrbová K.Kléma J.Pikal P.Lubovská Z.Philimonenko A.Franco F.Topinka J.Rössner P. Published on 2019 Metadata Toxicology in vitro. 54: 178-188.