10. 07. 2023
Lsp1 partially substitutes Pil1 function in eisosome assembly under stress conditions
Lecturer: Ing. Petra Veselá / Department of Functional Organisation of Biomembranes
The seminar was cancelled due to the illness of the lecturer! We will let you know soon about the alternative date. We apologise for cancelling this event and for any inconvenience this may cause. Thank you for your understanding.
Annotation: Eisosomes are large hemitubular structures that underlie the invaginated microdomains in the plasma membrane of various organisms and take part in the cellular stress response. In the yeast Saccharomyces cerevisiae, they are organized by BAR-domain containing proteins, Pil1 and Lsp1. While under normal laboratory conditions, deletion of the PIL1 gene results in the inability of cells to assemble eisosomes, deletion of LSP1 shows no apparent phenotype. We show that under stress conditions, Lsp1 takes over the Pil1 function and forms eisosomes even in the absence of Pil1.