Department

Department of Toxicology and Molecular Epidemiology

Research Department

Head of the Department

Pavel Rössner

Publications

Select year

Traffic-related diesel pollution particles impair the lysosomal functions of human iPSC-derived microglia

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiOhtonen S.Jäntti H.Giudice L.Mohamed A.Shakirzyanova A.Závodná T.Belevich I.Yan H.Sabogal-Guáqueta A. M.Saveleva L.Väänänen M.-A.Rillo-Albert A.Perciballi E.Ferrari D.Tervo M.-M.Gómez-Budia M.Krejčík Z.Aakko-Saksa P.Koistinaho J.Lehtonen Š.Kanninen K. M.Topinka J.Jokitalo E.Sierra A.Schmidt M.Dolga A. M.Jalava P. I.Korhonen P.Malm T. Published on 2025 Metadata Environ Int . 2025 May:199:109467. doi: 10.1016/j.envint.2025.109467. Epub 2025 May 5.

Traffic-related ultrafine particles influence gene regulation in olfactory mucosa cells altering PI3K/AKT signaling

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiMussalo L.Afonin A. M.Závodná T.Krejčík Z.Hoňková K.Fayad C.Shahbaz M. A.Kalapudas J.Penttilä E.Löppönen H.Koivisto A. M.Malm T.Topinka J.Jalava P.Lampinen R.Kanninen K. M. Published on 2025 Metadata Environ Int . 2025 May:199:109484. doi: 10.1016/j.envint.2025.109484. Epub 2025 Apr 17.

Comparative Study of Functionalized Carbosilane Dendrimers for siRNA Delivery: Synthesis, Cytotoxicity, and Biophysical Properties

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiMüllerová M.Tarach P.Strašák T.Cuřínová P.Petrickovic R.Závodná T.Topinka J.Janaszewska A.Klajnert-Maculewicz B.Červenková Št'astná L. Published on 2024 Metadata ACS Omega. 2024 Dec 20;10(1):1047-1060. doi: 10.1021/acsomega.4c08314. eCollection 2025 Jan 14.

Traffic-related ultrafine particles impair mitochondrial functions in human olfactory mucosa cells - Implications for Alzheimer's disease

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiMussalo L.Lampinen R.Avesani S.Závodná T.Krejčík Z.Kalapudas J.Penttilä E.Löppönen H.Koivisto A. M.Malm T.Topinka J.Giugno R.Jalava P.Kanninen K. M. Published on 2024 Metadata Redox Biol . 2024 Sep:75:103272. doi: 10.1016/j.redox.2024.103272. Epub 2024 Jul 19.

Gene expression profiles and protein-protein interaction networks in THP-1 cells exposed to metal-based nanomaterials

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiŠíma M.Líbalová H.Závodná T.Vrbová K.Kléma J.Rössner P. Published on 2024 Metadata Environ Toxicol Pharmacol . 2024 Jun:108:104469. doi: 10.1016/j.etap.2024.104469. Epub 2024 May 15.

Personal exposure monitoring to polycyclic aromatic hydrocarbons bound to size-segregated aerosol

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiParizek O.Závodná T.Milcová A.Drabova L.Stupak M.Gomersall V.Schmuczerova J.Jirik V.Topinka J.Pulkrabova J. Published on 2024 Metadata Atmospheric Pollution Research Volume 15, Issue 6, June 2024, 102122

The Genotoxicity of Organic Extracts from Particulate Emissions Produced by Neat Gasoline (E0) and a Gasoline-Ethanol Blend (E15) in BEAS-2B Cells

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiLíbalová H.Závodná T.Elzeinová F.Barošová H.Červená T.Milcová A.Vaňková J.Paradeisi F.Vojtisek-Lom M.Sikorová J.Topinka J.Rössner P. Published on 2023 Metadata J Xenobiot . 2023 Dec 21;14(1):1-14. doi: 10.3390/jox14010001.

Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiMussalo L.Avesani S.Shahbaz M. A.Závodná T.Saveleva L.Järvinen A.Lampinen R.Belaya I.Krejčík Z.Ivanova M.Hakkarainen H.Kalapudas J.Penttilä E.Löppönen H.Koivisto A. M.Malm T.Topinka J.Giugno R.Aakko-Saksa P.Chew S.Rönkkö T.Jalava P.Kanninen K. M. Published on 2023 Metadata Sci Total Environ. 2023 Dec 20:905:167038. doi: 10.1016/j.scitotenv.2023.167038. Epub 2023 Sep 13.

High aspect ratio nanomaterial-induced macrophage polarization is mediated by changes in miRNA levels

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiErdem J. S.Závodná T.Ervik T. K.Skare Ø.Hron T.Anmarkrud K. H.Kuśnierczyk A.Catalán J.Ellingsen D. G.Topinka J.Zienolddiny-Narui S. Published on 2023 Metadata Front Immunol . 2023 Jan 27:14:1111123. doi: 10.3389/fimmu.2023.1111123. eCollection 2023.

Lactose-Functionalized Carbosilane Glycodendrimers Are Highly Potent Multivalent Ligands for Galectin-9 Binding: Increased Glycan Affinity to Galectins Correlates with Aggregation Behavior

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiMüllerová M.Hovorková M.Závodná T.Červenková Štastná L.Krupková A.Hamala V.Nováková K.Topinka J.Bojarová P.Strašák T. Published on 2023 Metadata Biomacromolecules. 2023 Nov 13;24(11):4705-4717. doi: 10.1021/acs.biomac.3c00426. Epub 2023 Sep 8.

Differential DNA damage response and cell fate in human lung cells after exposure to genotoxic compounds

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiLíbalová H.Závodná T.Margaryan H.Elzeinová F.Milcová A.Vrbová K.Barošová H.Červená T.Topinka J.Rössner P. Published on 2023 Metadata Toxicol In Vitro. 2024 Feb:94:105710. doi: 10.1016/j.tiv.2023.105710. Epub 2023 Oct 13.

An approach to classifying occupational exposures to endocrine disrupting chemicals by sex hormone function using an expert judgment process.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiPřichystalová R.Caron-Beaudoin E.Richardson l.Dirkx E.Amadou A.Závodná T.Cihak R.Cogliano V.Hynes J.Pelland-St-Pierre L.Verner M.A.van Tongeren M.Ho V. Published on 2021 Metadata Journal of Exposure Science and Environmental Epidemiology. 07/20.

Transcription profiles in BEAS-2B cells exposed to organic extracts from particulate emissions produced by a port-fuel injection vehicle, fueled with conventional fossil gasoline and gasoline-ethanol blend.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiLíbalová H.Závodná T.Vrbová K.Sikorová J.Vojtíšek-Lom M.Beránek V.Pechout M.Kléma J.Ciganek M.Machala M.Neca J.Rössner P.Topinka J. Published on 2021 Metadata Mutation Research – Genetic Toxicology and Environmental Mutagenesis. 872: 503414.

Testing Strategies of the In Vitro Micronucleus Assay for the Genotoxicity Assessment of Nanomaterials in BEAS-2B Cells.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiČervená T.Rössnerová A.Závodná T.Sikorová J.Vrbová K.Milcová A.Topinka J.Rössner P. Published on 2021 Metadata Nanomaterials. 11(8):1929.

Biometal Dyshomeostasis in Olfactory Mucosa of Alzheimer's Disease Patients.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiLampinen R.Gorova V.Avesani S.Liddell J.Penttila E.Závodná T.Krejčík Z.Lehtola J.M.Saari T.Kalapudas J.Hannonen S.Lopponen H.Topinka J.Topinka J.Koivisto A.M.White A.R.Giugno R.Kanninen K.M. Published on 2022 Metadata International Journal of Molecular Sciences. 23(8): 4123.

Molecular Responses in THP-1 Macrophage-Like Cells Exposed to Diverse Nanoparticles.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiZávodná T.Javorková E.Vrbová K.Zajícová A.Holáň V.Pinkas D.Philimonenko V.Sikorová J.Kléma J.Topinka J.Rössner P. Published on 2019 Metadata Nanomaterials. 9(5): 687.

Nano-TiO2 stability in medium and size as important factors of toxicity in macrophage-like cells.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiZávodná T.Sikorová J.Milcová A.Vrbová K.Kléma J.Pikal P.Lubovská Z.Philimonenko A.Franco F.Topinka J.Rössner P. Published on 2019 Metadata Toxicology in vitro. 54: 178-188.