Institutional Seminar Series 02/2024

The role of miR-20a in the injured CNS

Lecturer: Mgr. Ivan Arzhanov / Department of Neuroregeneration

Annotation: Spinal cord injury (SCI) involves damage to any part of the spinal cord, leading to nervous cell death and disruption of conduction pathways. This damage results in the loss of motor and sensory function below the injury site, potentially causing paralysis and, in severe cases, complete paralysis. Following SCI, a myriad of genes undergo dysregulation, accompanied by alterations in the expression of microRNAs (miRNAs). MiRNAs, small non-coding RNA molecules, play a pivotal regulatory role in various biological processes by interfering with mRNA. In our experiments, the expression of miR-20a was significantly upregulated for at least one week post-trauma. MiR-20a targets numerous genes, hindering the regenerative process of nervous tissue. However, inhibiting miR-20a decreases pro-apoptotic gene expression while facilitating the expression of anti-apoptotic genes, thereby diminishing neural cell death after injury. During this seminar, we will summarise the data regarding changes in mRNAs, miRNAs, and protein expression following SCI. Subsequently, we will specifically focus on miR-20a and its role in basic cellular processes following SCI.

The seminar will take place on 1. 2. 2024 from 2 p.m. in the Turquoise Auditorium of the IEM CAS.

We look forward to your participation.