Department

Department of Toxicology and Molecular Epidemiology

Research Department

Head of the Department

Pavel Rössner

Education / Academic Qualifications

  • 2005

    DSc. (Res. Prof.) / Czech Academy of Sciences / Biomedicine

     

  • 1986

    CSc. (Ph.D.) / Faculty of Nuclear and Physical Engineering, Czech Technical University in Prague / Physical Chemistry

  • 1979

    Ing. (M.Sc.) / Faculty of Nuclear and Physical Engineering, Czech Technical University in Prague / Physical Chemistry

Professional Associations

  • Society of Toxicology
  • European Environmental Mutagen and Genomics Society
  • Czech and Slovak Biological Society

Publications

Select year

Transcriptomic and epigenomic profiling reveals alteredresponses to diesel emissions in Alzheimer’s disease both invitro and in population-based data

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiSaveleva L.Červená T.Mengoni C.Šíma M.Krejčík Z.Vrbová K.Sikorová J.Mussalo L.de Crom T. O. E.Šímová Z.Ivanova M.Shahbaz M. A.Penttilä E.Löppönen H.Koivisto A. M.Ikram M. A.Jalava P. I.Malm T.Chew S.Vojtíšek M.Topinka J.Giugno R.Rössner P.Kanninen K. M. Published on 2024 Metadata Alzheimers Dement . 2024 Dec 24. doi: https://doi.org/10.1002/alz.14347.

Traffic-related ultrafine particles impair mitochondrial functions in human olfactory mucosa cells - Implications for Alzheimer's disease

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiMussalo L.Lampinen R.Avesani S.Závodná T.Krejčík Z.Kalapudas J.Penttilä E.Löppönen H.Koivisto A. M.Malm T.Topinka J.Giugno R.Jalava P.Kanninen K. M. Published on 2024 Metadata Redox Biol . 2024 Sep:75:103272. doi: 10.1016/j.redox.2024.103272. Epub 2024 Jul 19.

Exposure to source-specific air pollution in residential areas and its association with dementia incidence: a cohort study in Northern Sweden

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiOudin A.Raza W.Flanagan E.Segersson D.Jalava P.Kanninen K. M.Rönkkö T.Giugno R.Sandström T.Muala A.Topinka J.Sommar J. Published on 2024 Metadata Sci Rep . 2024 Jul 5;14(1):15521. doi: 10.1038/s41598-024-66166-y.

The effect of air pollution on selected immune system parameters, 8-isoprostane, and alpha-1-antitrypsin of people living in environmentally distinct regions

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiJiřík V.Machaczka O.Riedlová P.Kramná D.Siemiatkowski G.Ośródka L.Krajny E.Ambrož A.Topinka J.Rössner P. Published on 2024 Metadata Environmental Sciences Europe, Published: 02 July 2024, Volume 36, article number 125, (2024)

Personal exposure monitoring to polycyclic aromatic hydrocarbons bound to size-segregated aerosol

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiParizek O.Závodná T.Milcová A.Drabova L.Stupak M.Gomersall V.Schmuczerova J.Jirik V.Topinka J.Pulkrabova J. Published on 2024 Metadata Atmospheric Pollution Research Volume 15, Issue 6, June 2024, 102122

Transcriptional and phenotypical alterations associated with a gradual benzo[a]pyrene-induced transition of human bronchial epithelial cells into mesenchymal-like cells

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiHýžďalová M.Procházková J.Straková N.Pěnčíková K.Strapáčová S.Slováčková J.Kajabová S.Líbalová H.Topinka J.Kabátková M.Vondráček J.Mollerup S.Machala M. Published on 2024 Metadata Environ Toxicol Pharmacol . 2024 Apr:107:104424. doi: 10.1016/j.etap.2024.104424. Epub 2024 Mar 22.

The Genotoxicity of Organic Extracts from Particulate Emissions Produced by Neat Gasoline (E0) and a Gasoline-Ethanol Blend (E15) in BEAS-2B Cells

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiLíbalová H.Závodná T.Elzeinová F.Barošová H.Červená T.Milcová A.Vaňková J.Paradeisi F.Vojtisek-Lom M.Sikorová J.Topinka J.Rössner P. Published on 2023 Metadata J Xenobiot . 2023 Dec 21;14(1):1-14. doi: 10.3390/jox14010001.

Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiMussalo L.Avesani S.Shahbaz M. A.Závodná T.Saveleva L.Järvinen A.Lampinen R.Belaya I.Krejčík Z.Ivanova M.Hakkarainen H.Kalapudas J.Penttilä E.Löppönen H.Koivisto A. M.Malm T.Topinka J.Giugno R.Aakko-Saksa P.Chew S.Rönkkö T.Jalava P.Kanninen K. M. Published on 2023 Metadata Sci Total Environ. 2023 Dec 20:905:167038. doi: 10.1016/j.scitotenv.2023.167038. Epub 2023 Sep 13.

High aspect ratio nanomaterial-induced macrophage polarization is mediated by changes in miRNA levels

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiErdem J. S.Závodná T.Ervik T. K.Skare Ø.Hron T.Anmarkrud K. H.Kuśnierczyk A.Catalán J.Ellingsen D. G.Topinka J.Zienolddiny-Narui S. Published on 2023 Metadata Front Immunol . 2023 Jan 27:14:1111123. doi: 10.3389/fimmu.2023.1111123. eCollection 2023.

Lung-depositing surface area (LDSA) of particles in office spaces around Europe: Size distributions, I/O-ratios and infiltration

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiSilvonen V.Salo L.Raunima T.Vojtisek-Lom M.Ondracek J.Topinka J.Schins R. P. F.Lepistö T.Lintusaari H.Saarikoski S.Barreira L. M. F.Hoivala J.Markkula L.Kulmala IVinha J.Karjalainen P.Rönkkö T. Published on 2023 Metadata Building and Environment. 246: 110999. Volume 246, 1 December 2023, https://doi.org/10.1016/j.buildenv.2023.110999

Lactose-Functionalized Carbosilane Glycodendrimers Are Highly Potent Multivalent Ligands for Galectin-9 Binding: Increased Glycan Affinity to Galectins Correlates with Aggregation Behavior

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiMüllerová M.Hovorková M.Závodná T.Červenková Štastná L.Krupková A.Hamala V.Nováková K.Topinka J.Bojarová P.Strašák T. Published on 2023 Metadata Biomacromolecules. 2023 Nov 13;24(11):4705-4717. doi: 10.1021/acs.biomac.3c00426. Epub 2023 Sep 8.

Differential DNA damage response and cell fate in human lung cells after exposure to genotoxic compounds

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiLíbalová H.Závodná T.Margaryan H.Elzeinová F.Milcová A.Vrbová K.Barošová H.Červená T.Topinka J.Rössner P. Published on 2023 Metadata Toxicol In Vitro. 2024 Feb:94:105710. doi: 10.1016/j.tiv.2023.105710. Epub 2023 Oct 13.

Particle lung deposited surface area (LDSAal) size distributions in different urban environments and geographical regions: Towards understanding of the PM2.5 dose–response

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiLepistö T.Lintusaari H.Oudin A.Barreira L. M. F.Niemi J. V.Karjalainen P.Salo L.Silvonen V.Markkula L.Hoivala J.Marjanen P.Martikainen S.Aurela M.Reyes F. R.Oyola P.Kuuluvainen H.Manninen H. E.Schins R. P. F.Vojtisek-Lom M.Ondracek J.Topinka J.Timonen H.Jalava P.Saarikoski S.Rönkkö T. Published on 2023 Metadata Environ Int. 2023 Oct:180:108224. doi: 10.1016/j.envint.2023.108224. Epub 2023 Sep 20.

Comparisons of lifetime exposures between differently polluted areas and years of life lost due to all-cause mortality attributable to air pollution

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiMachaczka O.Jiřík V.Janulková T.Michalík J.Siemiatkowski G.Osrodka L.Krajny E.Topinka J. Published on 2023 Metadata Environmental Sciences Europe volume 35, Article number: 73 (2023)

Maternal Diet Quality and Health Status of Newborns.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiPavlíková H.Ambrož A.Hoňková K.Chvojková I.Šrám R.Rössner P.Topinka J.Gramblička T.Parizek O.Parizkova D.Pulcmanová J.Rössnerová A. Published on 2022 Metadata Foods. 11(23): 3893.

TUBE Project: Transport-Derived Ultrafines and the Brain Effects.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiMartikainen M.V.Aakko-Saksa P.van den Broek L.Flemming R.C.Carare R.O.Chew S.Dinnyes A.Giugno R.Kanninen K.M.Malm T.Muala A.Nedergaard M.Oudin A.Oyola P.Pfeiffer T.V.Ronkko T.Sandstrom T.Schins R.P.F.Topinka J.Yang M.Zeng X.Westerink R.H.S.Jalava P.I. Published on 2022 Metadata International Journal of Environmental Research and Public Health. 19(1): 311.

Genome-Wide DNA Methylation in Policemen Working in Cities Differing by Major Sources of Air Pollution.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiHoňková K.Rössnerová A.Chvojková I.Milcová A.Margaryan H.Pastorková A.Ambrož A.Rössner P.Jirik V.Rubeš J.Šrám R.Topinka J. Published on 2022 Metadata International Journal of Molecular Sciences. 23(3):1666.

Oxidative Stress and Antioxidant Response in Populations of the Czech Republic Exposed to Various Levels of Environmental Pollutants.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiAmbrož A.Rössner P.Rössnerová A.Hoňková K.Milcová A.Pastorková A.Klema J.Pulkrabová J.Pařízek O.Vondrášková V.Zelenka J.Vrzáčková N.Schmuczerová J.Topinka J.Šrám R. Published on 2022 Metadata International Journal of Environmental Research and Public Health. Volume. 19(6): 3609.

Short- and medium-chain chlorinated paraffins in human blood serum of Czech population.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiTomasko J.Stupak M.Pařízková D.Polachová A.Šrám R.Topinka J.Pulkrabová J. Published on 2021 Metadata Science of the Total Environment. 797: 149126.

Individual DNA Methylation Pattern Shifts in Nanoparticles-Exposed Workers Analyzed in Four Consecutive Years.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiRössnerová A.Hoňková K.Chvojková I.Pelcová D.Ždímal V.Hubáček J. A.Lischková L.Vlčková Š.Ondráček J.Dvořáčková Š.Topinka J.Rössner P. Published on 2021 Metadata International Journal of Molecular Sciences. 22(15): 7834.

Markers of lipid oxidation and inflammation in bronchial cells exposed to complete gasoline emissions and their organic extracts.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiRössner P.Červená T.Vojtíšek-Lom M.Neca J.Ciganek, M.Vrbová K.Ambrož A.Nováková Z.Elzeinová F.Šíma M.Šímová Z.Holáň V.Beránek V.Pechout M.Macoun D.Rössnerová A.Topinka J. Published on 2021 Metadata Chemosphere. 281: 130833.

Biomonitoring of 89 POPs in blood serum samples of Czech city policemen.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiPolachová A.Gramblicka T.Bechynská K.Parizek O.Parizková D.Dvořáková D.Hoňková K.Rössnerová A.Rössner P.Šrám R.Topinka J.Pulkrabová J. Published on 2021 Metadata Environmental Pollution. 291: 118140.

Transcription profiles in BEAS-2B cells exposed to organic extracts from particulate emissions produced by a port-fuel injection vehicle, fueled with conventional fossil gasoline and gasoline-ethanol blend.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiLíbalová H.Závodná T.Vrbová K.Sikorová J.Vojtíšek-Lom M.Beránek V.Pechout M.Kléma J.Ciganek M.Machala M.Neca J.Rössner P.Topinka J. Published on 2021 Metadata Mutation Research – Genetic Toxicology and Environmental Mutagenesis. 872: 503414.

A prolonged exposure of human lung carcinoma epithelial cells to benzo[a]pyrene induces p21-dependent epithelial-to-mesenchymal transition (EMT)-like phenotype.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiHýžďalová M.Procházková J.Strapáčová S.Svržková L.Vacek O.Fedr R.Andrysík Z.Hrubá E.Líbalová H.Kléma J.Topinka J.Mašek J.Souček K.Vondráček J.Machala M. Published on 2021 Metadata Chemosphere. 263: 128126.

Ordinary Gasoline Emissions Induce a Toxic Response in Bronchial Cells Grown at Air-Liquid Interface View Web of Science ResearcherID and ORCID.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiČervená T.Vojtíšek-Lom M.Vrbová K.Ambrož A.Nováková Z.Elzeinová F.Šíma M.Beránek V.Pechout M.Macoun D.Kléma J.Rössnerová A.Ciganek M.Topinka J.Rössner P. Published on 2020 Metadata International Journal of Molecular Sciences. 22(1): 79.

Testing Strategies of the In Vitro Micronucleus Assay for the Genotoxicity Assessment of Nanomaterials in BEAS-2B Cells.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiČervená T.Rössnerová A.Závodná T.Sikorová J.Vrbová K.Milcová A.Topinka J.Rössner P. Published on 2021 Metadata Nanomaterials. 11(8):1929.

Assessment of organohalogenated pollutants in breast milk from the Czech Republic.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiPařízek O.Gramblička T.Pařízková D.Polachová A.Bechynská K.Dvořáková D.Stupak M.Dušek J.Pavlíková J.Topinka J.Šrám R.Pulkrabová J. Published on 2023 Metadata Science of the Total Environment. 871: 161938.

Effects of various environments on epigenetic settings and chromosomal damage.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiRössnerová A.Elzeinová F.Chvojková I.Hoňková K.Šíma M.Milcová A.Pastorková A.Schmuczerová J.Rössner P.Topinka J.Šrám R. Published on 2023 Metadata Environmental Pollution. 323: 121290.

A Simultaneous Determination of Benzophenone and Camphor UV-Filters, Together with Metabolites of Polycyclic Aromatic Hydrocarbons, in Human Urine

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiCiglova K.Vondraskova V.Milcová A.Rössnerová A.Šrám R.Topinka J.Pulkrabova J. Published on 2023 Metadata Expo Health (2023). https://doi.org/10.1007/s12403-023-00554-z

Biometal Dyshomeostasis in Olfactory Mucosa of Alzheimer's Disease Patients.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiLampinen R.Gorova V.Avesani S.Liddell J.Penttila E.Závodná T.Krejčík Z.Lehtola J.M.Saari T.Kalapudas J.Hannonen S.Lopponen H.Topinka J.Topinka J.Koivisto A.M.White A.R.Giugno R.Kanninen K.M. Published on 2022 Metadata International Journal of Molecular Sciences. 23(8): 4123.

Molecular Responses in THP-1 Macrophage-Like Cells Exposed to Diverse Nanoparticles.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiZávodná T.Javorková E.Vrbová K.Zajícová A.Holáň V.Pinkas D.Philimonenko V.Sikorová J.Kléma J.Topinka J.Rössner P. Published on 2019 Metadata Nanomaterials. 9(5): 687.

Short-term and Long-term Exposure of the MucilAir™ Model to Polycyclic Aromatic Hydrocarbons

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiČervená T.Vrbová K.Rössnerová A.Topinka J.Rössner P. Published on 2019 Metadata Altern Lab Anim . 2019 Mar;47(1):9-18. doi: 10.1177/0261192919841484. Epub 2019 Apr 30.

Nano-TiO2 stability in medium and size as important factors of toxicity in macrophage-like cells.

 DepartmentDepartment of Toxicology and Molecular Epidemiology AutořiZávodná T.Sikorová J.Milcová A.Vrbová K.Kléma J.Pikal P.Lubovská Z.Philimonenko A.Franco F.Topinka J.Rössner P. Published on 2019 Metadata Toxicology in vitro. 54: 178-188.