Department

Department of Neurochemistry

Research Department

Head of the Department

Martin Horák

Publications

Select year

Dizocilpine derivatives as neuroprotective NMDA receptor antagonists without psychomimetic side effects

 DepartmentDepartment of Neurochemistry AutořiKonecny J.Misiachna A.Chvojkova M.Kletečková L.Kolcheva M.Novak M.Prchal L.Ladislav M.Hemelíková K.Netolický J.Hrabinova M.Kobrlova T.Zdarova Karasova J.Pejchal J.Fibigar J.Vecera Z.Kucera T.Jendelová P.Baráčková P.Langore E.Doderović J.Pang Y.P.Valeš K.Korabecny J.Soukup O.Horák M. Published on 2024 Metadata Eur J Med Chem . 2024 Oct 18:280:116981. doi: 10.1016/j.ejmech.2024.116981.

Potent and reversible open-channel blocker of NMDA receptor derived from dizocilpine with enhanced membrane-to-channel inhibition

 DepartmentDepartment of Neurochemistry Department of Cellular Neurophysiology AutořiMisiachna A.Konecny J.Kolcheva M.Ladislav M.Prchal L.Netolický J.Kortus S.Baráčková P.Langore E.Novak M.Hemelíková K.Heřmanová Z.Hrochová M.Pelikánová A.Odvarkova J.Pejchal J.Kassa J.Zdarova Karasova J.Korabecny J.Soukup O.Horák M. Published on 2024 Metadata Biomed Pharmacother Actions Search in PubMed Search in NLM Catalog Add to Search . 2024 Sep:178:117201. doi: 10.1016/j.biopha.2024.117201. Epub 2024 Jul 24.

Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition

 DepartmentDepartment of Neurochemistry AutořiMisiachna A.Svobodova B.Netolický J.Chvojkova M.Kleteckova L.Prchal L.Novak M.Hrabinova M.Kucera T.Muckova L.Moravcova Z.Zdarova Karasova J.Pejchal J.Blazek F.Malinak D.Hakenova K.Hrčka Krausová B.Kolcheva M.Ladislav M.Korabecny J.Pahnke J.Vales K.Horák M.Soukup O. Published on 2024 Metadata Eur J Med Chem . 2024 Feb 15:266:116130. doi: 10.1016/j.ejmech.2024.116130. Epub 2024 Jan 7.

Subunit-Dependent Surface Mobility and Localization of NMDA Receptors in Hippocampal Neurons Measured Using Nanobody Probes

 DepartmentDepartment of Neurochemistry AutořiKortus S.Řeháková K.Klima M.Kolcheva M.Ladislav M.Langore E.Baráčková P.Netolický J.Misiachna A.Hemelíková K.Humpolickova J.Chalupska D.Silhan J.Kaniaková M.Hrčka Krausová B.Boura E.Zapotocky M.Horák M. Published on 2023 Metadata J Neurosci. 2023 Jun 28;43(26):4755-4774. doi: 10.1523/JNEUROSCI.2014-22.2023. Epub 2023 Jun 7.

The Extracellular Domains of GluN Subunits Play an Essential Role in Processing NMDA Receptors in the ER.

 DepartmentDepartment of Neurochemistry AutořiHorák M.Baráčková P.Langore E.Netolický J.Rivas-Ramirez P.Řeháková K. Published on 2021 Metadata Frontiers in Neuroscience. 15: 603715.

The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors.

 DepartmentDepartment of Neurochemistry AutořiKolcheva M.Ladislav M.Netolický J.Kortus S.Řeháková K.Hrčka Krausová B.Hemelíková K.Misiachna A.Kádková A.Klíma M.Chalupská D.Horák M. Published on 2023 Metadata Neuropharmacology. 222: 109297.