22. 04. 2025
Transcriptome changes in humans occupationally exposed to nanoparticles
Lecturer: Zuzana Šímová, M.Sc. / Department of Toxicology and Molecular Epidemiology
Annotation: Epidemiological studies have attracted attention to nanoparticles’ (NPs) potential negative effects on human health. We investigated the effect of occupational inhalation exposure to NPs in a group of acutely (working with dental nanocomposite material) and chronically (welding on metal surfaces, machining of the nanocomposite) exposed workers on transcriptomic level changes. We analysed whole genome mRNA and miRNA expression profiles by NGS to identify the most significantly deregulated genes and to compare the profiles between them. Acute and chronic occupational exposure to NPs seems to have different effects on gene expression profiles. The results indicate that the impact of exposure to NPs is dependent on the working style and biological variability among study subjects.
The seminar will take place on 30. 4. 2025 from 2 p.m. in the Turquoise Auditorium of the IEM CAS.
We look forward to your participation.