22. 01. 2026
Transcription-replication conflicts with R-loop formation: origins, consequences, and role in anticancer therapy
Thursday 5. 3. 2026 | 14:00
Turquoise Lecture Hall of the IEM CAS (building Lb, 2nd floor)
Lecturer: Martin Andrš, PharmD, PhD | Department of Genome Biology
Annotation: Interference between DNA transcription and replication (TRCs) is a major source of replication stress and genome instability, and elucidating its origins and the mechanisms of its resolution is vital for understanding cancer progression and tailoring more efficient therapy. Elevated levels of reactive oxygen species (ROS) have been linked to increased TRCs and R-loops, leading to replication stress and transcription-associated DNA damage. In our current research, we focus on various sources of ROS in tumors, including oncogenes, hypoxia, and chemotherapy. Our goal is to explain why TRCs affect DNA replication, how cells resolve these situations, and how we can exploit tolerance pathways to improve the effectiveness of cancer therapy.