04. 12. 2025
Autophagy in axonal growth, injury and regeneration
Thursday 5. 2. 2026 | 14:00
Turquoise Lecture Hall of the IEM CAS (building Lb, 2nd floor)
Lecturer: Anda Cimpean, PhD | Centre of Reconstructive Neuroscience
Annotation: Autophagy is well known for its canonical role in maintaining cellular homeostasis by forming autophagosomes that mature into autolysosomes and degrade intracellular components. However, its role in neuronal growth and regeneration remains controversial. In recent years, increasing attention has been given to non-canonical functions of autophagy, particularly its interaction with the endosomal system, which has been proposed as a potential therapeutic target, although this remains poorly explored in neurons. Given that integrins are key regulators of axonal membrane expansion and growth cone dynamics and are largely recycled through endosomal pathways, we used a transgenic mouse model that enables live imaging of autophagic vesicles and labelling of β1 integrins to investigate autophagy–integrin dynamics during axon growth, axotomy, and regeneration.
Our results suggest that growth and regeneration represent distinct processes, with differential modulation of autophagy, endosomes, and their interaction, providing new insight into the complex role of autophagy in neuronal axons.
Data as a research asset
Thursday 5. 2. 2026 | 14:45
The time is approximate; the seminar will start once the previous seminar has finished.
Turquoise Lecture Hall of the IEM CAS (building Lb, 2nd floor)
Lecturer: Arzuv Čaryjeva, PhD | Data Manager | Director’s Secretariat
Annotation: The session will focus on treating research data as a valuable asset rather than a by-product and will provide practical, researcher-oriented guidance on FAIR data, data sharing, repositories, and Data Management Plans. We will look at real examples from everyday research practice and discuss how good data management can increase visibility, reuse, and long-term impact of your work, while also meeting funder and legal requirements. The seminar is designed to be clear, practical, and supportive, with space for questions and discussion.