16. 06. 2026
Potency and kinetic profiles of R-ketamine and S-ketamine at GluN1/GluN2A NMDA receptors
Lecturer: Claudia Valentina De Sanctis, MSc | Department of Neurochemistry
Annotation: NMDA receptors are key mediators of excitatory neurotransmission and important targets of ketamine. We compare the potency and kinetic profiles of R- and S-ketamine at GluN1/GluN2A receptors, with a particular focus on the N615S pore mutation. Differences in channel block, onset, and recovery are examined, and their potential relevance for future acute and chronic studies in the N615S mouse model is discussed.
The 5xFAD mouse model: Long-Term Potentiation (LTP), Behaviour and Amyloid-β Plaques
Lecturer: Gregory Klein Schneider, MSc | Department of Neurochemistry
Annotation: The 5xFAD mouse carries five genes correlated with familial Alzheimer’s disease. Here, we characterised this strain at 3, 6, and 9 months of age using the open field, elevated plus-maze, and novel object recognition tests, and we evaluated long-term potentiation in the hippocampus and amyloid-beta plaque deposition in the brain over time.