19. 12. 2025
KCTD12KO mice – a new genetic model of tinnitus
Thursday 8. 1. 2026 | 14:00
Turquoise Lecture Hall of the IEM CAS (building Lb, 2nd floor)
Lecturer: Adolf Melichar, MSc | Department of Auditory Neuroscience
Annotation: The KCTD12 protein is an accessory subunit of the GABAB receptor, significantly modulating its structural and functional properties. KCTD12 is highly expressed in the mammalian auditory system, but its significance for auditory function is unknown. In this presentation, we summarize our results showing that KCTD12 deletion leads to weakened inhibitory action in the central auditory pathway and behavioral manifestations of phantom perception. The results suggest that KCTD12 KO mice are a suitable model for studying the neurobiological mechanisms of tinnitus pathogenesis.