Ludmila Vodičková, M.D., Ph.D.

Polymorphisms within autophagy-related genes as susceptibility biomarkers for pancreatic cancer: A meta-analysis of three large European cohorts and functional characterization

Department of Molecular Biology of Cancer Gálvez-Montosa F.Peduzzi G.Sanchez-Maldonado J. M.Horst R. T.Cabrera-Serrano A. J.Gentiluomo M.Macauda A.Luque N.Ünal P.García-Verdejo F. J.Li Y.López J. A. L.Stein A.Bueno-de-Mesquita H. B.Arcidiacono P. G....Vodičková L....Dohan O.Tacelli M.Greenhalf W.Gazouli M.Neoptolemos J. P.Cavestro G. M.Boggi U.Latiano A.Hegyi P.Ginocchi L.Netea M. G.Sánchez-Rovira P.Canzian F.Campa D.Sainz J. 2025 Int J Cancer. 2025 Jan 15;156(2):339-352. doi: 10.1002/ijc.35196. Epub 2024 Sep 25.

Mitochondrial DNA damage, repair, and replacement in cancer

Department of Molecular Biology of Cancer Vodička P.Vodenková S.Danešová N.Vodičková L.Zobalova R.Tomášová K.Boukalova S.Berridge M. V.Neuzil J. 2024 Trends Cancer. 2024 Oct 21:S2405-8033(24)00212-7. doi: 10.1016/j.trecan.2024.09.010. Online ahead of print.

Haplotype analysis identifies functional elements in monoclonal gammopathy of unknown significance

Department of Molecular Biology of Cancer Thomsen H.Chattopadhyay S.Weinhold N.Vodička P.Vodičková L.Hoffmann P.Nöthen M.M.Jöckel K.H.Schmidt B.Hajek R.Hallmans G.Pettersson-Kymmer U.Späth F.Goldschmidt H.Hemminki K.Försti A. 2024 Blood Cancer J . 2024 Aug 20;14(1):140. doi: 10.1038/s41408-024-01121-8.

Frequencies of chromosomal aberrations and related biochemical parameters in welders

Department of Molecular Biology of Cancer Vodička P.Musak L.Grendar M.Valachova J.Vodičková L.Halasova E. 2024 Mutat Res Genet Toxicol Environ Mutagen . 2024 Aug-Sep:898:503806. doi: 10.1016/j.mrgentox.2024.503806. Epub 2024 Jul 25.

Telomere length as a predictor of therapy response and survival in patients diagnosed with ovarian carcinoma

Department of Molecular Biology of Cancer Tomášová K.Seborova K.Kroupa M.Horák J.Kavec M.Vodičková L.Rob L.Hruda M.Mrhalova M.Bartakova A.Bouda J.Fleischer T.Kristensen V. N.Vodička P.Vaclavikova R. 2024 Heliyon . 2024 Jun 29;10(13):e33525. doi: 10.1016/j.heliyon.2024.e33525. eCollection 2024 Jul 15.

Fecal miRNA profiles in colorectal cancers with mucinous morphology

Department of Molecular Biology of Cancer Naccarati A.Dragomir M. P.Tarallo S.Gagliardi A.Alberini V.Buchler T.Gallo G.Vymetálková V.Vodičková L.Vodička P.Pardini B.Ferrero G. 2024 Mutagenesis . 2024 Jun 6:geae015. doi: 10.1093/mutage/geae015. Online ahead of print.

Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Department of Molecular Biology of Cancer Chen Z.Guo X.Tao R.Huyghe J. R.Law P. J.Fernandez-Rozadilla C.Ping J.Jia G.J. LongLi C....Vodička P.Vodičková L.Vymetálková V....Hsu L.Cai Q.Dunlop M. G.Gruber S. B.Houlston R. S.Moreno V.Casey G.Peters U.Tomlinson I.Zheng W. 2024 Nat Commun . 2024 Apr 26;15(1):3557. doi: 10.1038/s41467-024-47399-x.

Commentary: Special Issue - Current Understanding of Colorectal and Pancreatic Cancers

Department of Molecular Biology of Cancer Vodička P.Vodičková L. 2024 Mutagenesis . 2024 Mar 29:geae009. doi: 10.1093/mutage/geae009. Online ahead of print.

Genetic And Environmental Associations Of Nonspecific Chromosomal Aberrations

Department of Molecular Biology of Cancer Hemminki K.Niazi Y.Vodičková L.Vodička P.Försti A. 2024 Mutagenesis. 2024 Feb 29:geae006. doi: 10.1093/mutage/geae006. Online ahead of print.

Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk

Department of Molecular Biology of Cancer Ünal P.Lu Y.Bueno-de-Mesquita B.van Eijck C. H. J.Talar-Wojnarowska R.Szentesi A.Gazouli M.Kreivenaite E.Tavano F.Małecka-Wojciesko E....Vodičková L....Červená K.Pasquali C. Lawlor R. T.Bazzocchi F.Kupcinskas J.Capurso G.Campa D.Canzian F. 2024 Hum Genomics . 2024 Feb 2;18(1):12. doi: 10.1186/s40246-024-00576-x.

Elucidating the Risk of Colorectal Cancer for Variants in Hereditary Colorectal Cancer Genes

Department of Molecular Biology of Cancer Thomas M.Qu C.Wang X.Huyghe J. R.Joo J. E.Georgeson P.Arndt V.Berndt S. I.Bézieau S.Bien S. A.Bishop D. T.Brenner H.Brezina S.Burnett-Hartman A.Campbell P. T.Casey G.Castellví-Bel S.Chan A. T.Chang-Claude J.Chen X.Conti D. V.Cremolini C.Diergaarde B.Figueiredo J. C.FitzGerald L. M.Gago-Dominguez M.Gallinger S.Giles G. G.Gsu A.Gunter M. J.Hampe J.Hampel H.Harrison T. A.Hoffmeister M.Keku T. O.Kundaje A.Le Marchand L.Lenz H.-J.Li C. I.Li L.Lin Y.Lindblom A.Moreno V.Murphy N.Newcomb P. A.Newton C. C.Obón-Santacana M.Ogino S.Pai R. K.Palmer J. R.Pearlman R.Pharoah P. D. P.Phipps A. I.Platz E. A.Potter J. D.Rennert G.Sakoda L. C.Schafmayer C.Schmit S. L.Schoen R. E.Slattery M. L.Stadler Z. K.Steinfelder R. S.Thibodeau S. N.Ulrich C. M.Um C. Y.van Duijnhoven F. J. B.Van Guelpen B.Visvanathan K.Vodička P.Vodičková L.Vymetálková V.Weinstein S. J.White E.Winship I. M.Wolk A.Gruber S. B.Jenkins M. A.Hsu L.Buchanan D. D.Peters U. 2023 Gastroenterology. 2023 Oct;165(4):1070-1076.e3. doi: 10.1053/j.gastro.2023.06.032. Epub 2023 Jul 14.

Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations

Department of Molecular Biology of Cancer Thomas M.Su Y-R.Rosenthal E. A.Sakoda L. C.Schmit S. L.Timofeeva M. N.Chen Z.Fernandez-Rozadilla C.Law P. J.Murphy N.Carreras-Torres R.Diez-Obrero V.van Duijnhoven F. J. B.Jiang S.Shin A.Wolk A.Phipps A. I.Burnett-Hartman A.Gsur A.Chan A. T.Zauber A. G.Wu A. H.Lindblom A.Um C. Y.Tangen C. M.Gignoux C.Newton C.Haiman C. A.Qu C.Bishop D. T.Buchanan D. D.Crosslin D. R.Conti D. V.Kim D-H.Hauser E.White E.Siegel E.Schumacher F. R.Rennert G.Giles G. G.Hampel H.Brenner H.Oze I.Oh J. H.Lee J. K.Schneider J. L.Chang-Claude J.Kim J.Huyghe J. R.Zheng J.Hampe J.Greenson J.Hopper J. L.Palmer J. R.Visvanathan K.Matsuo K.Matsuda K.Jung K. J.Li L.Le Marchand L.Vodičková L.Bujanda L.Gunter M. J.Matejcic M.Jenkins M. A.Slattery M. L.D'Amato M.Wang M.Hoffmeister M.Woods M. O.Kim M.Song M.Iwasaki M.Du M.Udaltsova N.Sawada N.Vodička P.Campbell P. T.Newcomb P. A.Cai Q.Pearlman R.Pai R. K.Schoen R. E.Steinfelder R. S.Haile R. W.Vandenputtelaar R.Prentice R. L.Küry S.Castellví-Bel S.Tsugane S.Berndt S. I.Lee S. C.Brezina S.Weinstein S. J.Chanock S. J.Jee S. H.Kweon S-S.Vadaparampil S.Harrison T. A.Yamaji T.Keku T. O.Vymetálková V.Arndt V.Jia W-H.Shu X-O.Lin Y.Ahn Y-O.Stadler Z. K.Van Guelpen B.Ulrich C. M.Platz E. A.Potter J. D.Li C. I.Meester R.Moreno V.Figueiredo J. C.Casey G.Lansdorp Vogelaar I.Dunlop M. G.Gruber S. B.Hayes R. B.Pharoah P. D.Houlston R. S.Jarvik G. P.Tomlinson I. P.Zheng W.Corley D. A.Peters U.Hsu L. 2023 Nat Commun. 2023 Oct 2;14(1):6147. doi: 10.1038/s41467-023-41819-0.

Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians

Department of Molecular Biology of Cancer Piccardi M.Gentiluomo M.Bertoncini S.Pezzilli R.Erőss B.Bunduc S.Uzunoglu F. G.Talar-Wojnarowska R.Vanagas T.Sperti C....Vodičková L....Janciauskas D.Chen X.Chammas R.Goetz M.Brenner H.Archibugi L.Dannemann M.Canzian F.Tofanelli S.Campa D. 2023 Biol Res . 2023 Aug 13;56(1):46. doi: 10.1186/s40659-023-00457-y.

Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses

Department of Molecular Biology of Cancer Dimou N.Kim A. E.Flanagan O.Murphy N.Diez-Obrero V.Shcherbina A.Aglago E. K.Bouras E.Campbell P. T.Casey G....Vodička P.Vodičková L.White E.Wolk A.Woods M. O.Qu C.Kundaje A.Hsu L.Gauderman W. J.Gunter M. J.Peters U. 2023 Br J Cancer . 2023 Aug;129(3):511-520. doi: 10.1038/s41416-023-02312-z. Epub 2023 Jun 26.

A Fecal MicroRNA Signature by Small RNA Sequencing Accurately Distinguishes Colorectal Cancers: Results From a Multicenter Study

Department of Molecular Biology of Cancer Pardini B. Ferrero G.Tarallo S.Gallo G.Francavilla A.Licheri N.Trompetto M.Clerico G.Senore C.Peyre S.Vymetálková V.Vodičková L.Liska V.Vycital O.Levy M.Macinga P.Hucl T.Budinska E.Vodička P.Cordero F.Naccarati A. 2023 Gastroenterology. 2023 May 30;S0016-5085(23)00811-9. doi: 10.1053/j.gastro.2023.05.037. Online ahead of print.

Genetic Susceptibility in Understanding of Pancreatic Ductal Adenocarcinoma Risk: A Decade-Long Effort of the PANDORA Consortium.

Department of Molecular Biology of Cancer Vodičková L.Horák J.Vodička P. 2022 Cancer Epidemiology Biomarkers & Prevention. 31(5): 942-948.

Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study.

Department of Molecular Biology of Cancer Tsilidis K. K.Papadimitriou N.Dimou N.Gill D.Lewis S. J.Martin R. M.Murphy N.Markozannes G.Zuber V.Cross A. J.Burrows K.Lopez D. S.Key T. J.Travis R. C.Perez-Cornago A.Hunter D. J.van Duijnhoven F. J. B.Albanes D.Arndt V.Berndt S. I.Bézieau S.Bishop D. T.Boehm J.Brenner H.Burnett-Hartman A.Campbell P. T.Casey G.Castellví-Bel S.Chan A. T.Chang-Claude J.de la Chapelle A.Figueiredo J. C.Gallinger S. J.Giles G. G.Goodman P. J.Gsur A.Hampe J.Hampel H.Hoffmeister M.Jenkins M. A.Keku T. O.Kweon S.-S.Larsson S. C.Le Marchand L.Li C. I.Li L.Lindblom A.Martín V.Milne R. L.Moreno V.Nan H.Nassir R.Newcomb P. A.Offit K.Pharoah P. D. P.Platz E. A.Potter J. D.Qi L.Rennert G.Sakoda L. C.Schafmayer C.Slattery M. L.Snetselaar L.Schenk J.Thibodeau S. N.Ulrich C. M.Van Guelpen B.Harlid S.Visvanathan K.Vodičková L.Wang H.White E.Wolk A.Woods M. O.Wu A. H.Zheng W.Bueno-de-Mesquita B.Boutron-Ruault M.-C.Hughes D. J.Jakszyn P.Kühn T.Palli D.Riboli E.Giovannucci E. L.Banbury B. L.Gruber S. B.Peters U.Gunter M. J. 2021 Journal of Clinical Nutrition. 113(6): 1490-1502.

Monitoring of telomere dynamics in peripheral blood leukocytes in relation to colorectal cancer patients' outcomes.

Department of Molecular Biology of Cancer Tomášová K.Kroupa M.Zinková A.Korabečná M.Vymetálková V.Skrobánek P.Sojka L.Levy M.Hemminki K.Liška V.Hošek P.Kumar R.Vodičková L.Vodička P. 2022 Frontiers in Oncology. 12:962929.

Discovery of Long Non-Coding RNA MALAT1 Amplification in Precancerous Colorectal Lesions.

Department of Molecular Biology of Cancer Šišková A.Král J.Drabová J.Červená K.Tomášová K.Jungwirth J.Hucl T.Kohout P.Summerová S.Vodičková L.Vodička P.Vymetálková V. 2022 International Journal of Molecular Sciences. 23(14): 7656.

Complex molecular profile of DNA repair genes in epithelial ovarian carcinoma patients with different sensitivity to platinum-based therapy.

Department of Molecular Biology of Cancer Šeborová K.Hlaváč V.Holý P.Bjørklund S.Fleischer T.Rob L.Hruda M.Bouda J.Mrhalová M.Al Obeed Allah M.M.Vodičková L.Vodička P.Fiala O.Souček P.Kristensen V.Václavíková R. 2022 Frontiers in Oncology. 12: 1016958.

Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women.

Department of Molecular Biology of Cancer Peduzzi G.Archibugi L.Katzke V.Gentiluomo M.Capurso G.Milanetto A.C.Gazouli M.Goetz M.Brenner H.Vermeulen R. Ch.Talar-Wojnarowská R.Vanella G.Tavano F.Lucchesi M.Mohelniková-Duchonová B.Chen X.Kiudelis V.Hegyi P.Oliverius M.Stocker H.Stornello C.Vodičková L.Souček P.Neoptolemos J.P.Testoni S.G.G.Morelli L.Lawlor R.T.Basso D.Izbicki J.R.Ermini S.Kupcinskas J.Pezzilli R.Boggi U.van Laarhoven H.W.M.Szentesi A.Erőss B.Capretti G.Schöttker B.Skieceviciene J.Aoki M.N.van Eijck C.H.J.Cavestro G.M.Canzian F.Campa D. 2022 Scientific Reports. 12(1):18100

The Associations of Selenoprotein Genetic Variants with the Risks of Colorectal Adenoma and Colorectal Cancer: Case-Control Studies in Irish and Czech Populations.

Department of Molecular Biology of Cancer Mukhtar M.Ashfield N.Vodičková L.Vymetálková V.Levy M.Liska V.Bruha J.Bendová P.O‘Sullivan J.Doherty G.Sheahan K.Nolan B.Vodička P.Hughes D. 2022 Nutrients. 14(13): 2718.

Telomeric repeat-containing RNA (TERRA): Physiological functions and relevance in cancer.

Department of Molecular Biology of Cancer Kroupa M.Tomášová K.Kavec M.Skrobanek P.Buchler T.Kumar R.Vodičková L.Vodička P. 2022 Frontiers in Oncology. 12: 913314.

Oxidative Damage in Sporadic Colorectal Cancer: Molecular Mapping of Base Excision Repair Glycosylases MUTYH and hOGG1 in Colorectal Cancer Patients.

Department of Molecular Biology of Cancer Kavec M.Urbanová M.Makovický P.Opattová A.Tomášová K.Kroupa M.Kostovciková K.Šišková A.Navvabi N.Schneiderová M.Vymetálková V.Vodičková L.Vodička P. 2022 International Journal of Molecular Sciences. 23(10): 5704.

Mutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition.

Department of Molecular Biology of Cancer Jungwirth J.Urbanová M.Boot A.Hošek P.Bendová P.Šišková A.Švec J.Kment M.Tůmová D.Summerová S.Beneš Z.Buchler T.Kohout P.Hucl T.Matěj R.Vodičková L.van Wezel T.Vodička P.Vymetálková V. 2022 Scientific Reports. 12(1): 2570.

MiR-140 leads to MRE11 downregulation and ameliorates oxaliplatin treatment and therapy response in colorectal cancer patients.

Department of Molecular Biology of Cancer Horák J.Dolníková A.Cumaogullari O.Čumová A.Navvabi N.Vodičková L.Levy M.Schneiderová M.Liška V.Andera L.Vodička P.Opattová A. 2022 Frontiers in Oncology. 12:959407.

Genome-wide meta-analysis of monoclonal gammopathy of undetermined significance (MGUS) identifies risk loci impacting IRF-6.

Department of Molecular Biology of Cancer Clay-Gilmour A.Chattopadhyay S.Hildebrandt M.A.T.Thomsen H.Weinhold N.Vodička P.Vodičková L.Hoffmann P.Nothen M.M.Jockel K.H.Schmidt B.Langer Ch.Hájek R.Hallmans G.Pettersson-Kymmer U.Ohlsson C.Spath F.Houlston R.Goldschmidt H.Manasanch E.E.Norman A.Kumar S.Rajkumar S.V.Slager S.Forsti A.Vachon C.M.Hemminki K. 2022 Blood Cancer Journal. 12(4):60

The Interactions of DNA Repair, Telomere Homeostasis, and p53 Mutational Status in Solid Cancers: Risk, Prognosis, and Prediction.

Department of Molecular Biology of Cancer Vodička P.Andera L.Opattová A.Vodičková L. 2021 Cancer. 13(3): 479.

Glyphosate Interaction with eEF11 Indicates Altered Protein Synthesis: Evidence for Reduced Spermatogenesis and Cytostatic Effect.

Department of Molecular Biology of Cancer Sopko B.Tejral G.Bitti G.Sainz J.Garcia-Verdejo F.J.Martinez-Bueno M.Kumar A.Sanchez-Maldonado J.M.Diez-Villanueva A.Vodičková L.Vymetálková V.Sanchez V.M.Da Silva F.M.I.Sampaio-Marques B.Březina S.Butterbach K.ter Horst R.Hoffmeister M.Ludovico P.Jurado M.Li Y.Abate M.Medvediková M.Hajduch M.Chloupek J.Fajmonová J.Skoric M.Amler E.Erban T. 2021 ACS Omega. 6(23):14848-14857.

Polymorphisms within Autophagy-Related Genes Influence the Risk of Developing Colorectal Cancer: A Meta-Analysis of Four Large Cohorts.

Department of Molecular Biology of Cancer Sainz J.Garcia-Verdejo F.J.Martinez-Bueno M.Kumar A.Sanchez-Maldonado J.M.Diez-Villanueva A.Vodičková L.Vymetálková V.Sanchez V.M.Da Silva F.M.I.Sampaio-Marques B.Březina S.Butterbach K.ter Horst R.Hoffmeister M.Ludovico P.Jurado M.Sanchez-Rovira P.Netea M.G.Gsur A.Vodička P.Moreno V.Hemminki K.Brenner H.Chang-Claude J.Forsti A. 2021 Cancer. 13(6):1258.

Associations between pancreatic expression quantitative traits and risk of pancreatic ductal adenocarcinoma.

Department of Molecular Biology of Cancer Pistoni L.Gentiluomo M.Lu Y.Maturana E.L.Hlaváč V.Vanella G.Darvasi E.Milanetto A.C.Oliverius M.Vashist Y.Di Leo M.Mohelniková-Duchoňová B.Talar-Wojnarowská R.Gheorghe C.Petrone M.Ch.Strobel O.Arcidiacono P.G.Vodičková L.Szentesi A.Capurso G.Gajdan L.Malleo G.Theodoropoulos G.E.Basso D.Souček P.Brenner H.Lawlor R.T.Morelli L.Ivanauskas A.Kauffmann E.F.Macauda A.Gazouli M.Archibugi L.Nentwich M.Cavestro G.M.Vodička P.Landi S.Tavano F.Sperti C.Hackert T.Kupcinskas J.Pezzilli R.Andriulli A.Pollina L.Kreivenaite E.Gioffreda D.Jamroziak K.Hegyi P.Izbicki J.R.Testoni S.G.G.Zuppardo R.A.Bozzato D.Neoptolemos J.P.Malats N.Canzian F.Campa D. 2021 Carcinogenesis. 42(8): 1037-1045.

Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study.

Department of Molecular Biology of Cancer Nounu A.Richmond R.C.Stewart I.D.Surendran P.Wareham N.J.Butterworth A.Weinstein S.J.Albanes D.Baron J.A.Hopper J.L.Figueiredo J.C.Newcomb P.A.Lindor N.M.Casey G.Platz E.A.Marchand L.L.Ulrich C.M.Li Ch.I.van Dujinhoven F.J.B.Gsur A.Campbell P.T.Vodička P.Vodičková L.Amitay E.Alwers E.Chang-Claude J.Sakoda L.C.Slattery M.L.Schoen R.E.Gunter M.J.Castellví-Bel S.Kim H.R.Kweon S.S.Chan A.T.Li L.Zheng W.Bishop D.T.Buchanan D.D.Giles G.G.Gruber S.B.Rennert G.Stadler Z.K.Harrison T.A.Lin Y.Keku T.O.Woods M.O.Schafmayer C.Guelpen B.V.Gallinger S.Hampel H.Berndt S.I.Pharoah P.D.P.Lindblom A.Wolk A.Wu A.H.White E.Peters U.Drew D.A.Scherer D.Bermejo J.L.Brenner H.Hoffmeister M.Williams A.C.Relton C.L. 2021 Nutrients. 13(11):4164.

A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer.

Department of Molecular Biology of Cancer Nounu A.Greenhough A.Heesom K.J.Richmond R.C.Zheng J.Weinstein S.J.Albanes D.Baron J.A.Hopper J.L.Figueiredo J.C.Newcomb P.A.Lindor N.M.Casey G.Platz E.A.Le Marchand L.Ulrich C.M.Li Ch.I.van Duijnhoven F.J.B.Gsur A.Campbell P.T.Moreno V.Vodička P.Vodičková L.Brenner H.Chang-Claude J.Hoffmeister M.Sakoda L.C.Slattery M.Schoen R.E.Gunter M.J.Castellvi-Bel S.Kim H.R.Kweon S.S.Chan A.Li L.Zheng W.Bishop D.T.Buchanan D.D.Giles G.G.Gruber S.B.Rennert G.Stadler Z.K.Harrison T.A.Lin Y.Keku T.O.Woods M.O.Schafmayer C.Van Guelpen B.Gallinger S.Hampel H.Berndt S.I.Pharoah P.D.P.Lindblom A.Wolk A.Wu A.N.H.White E.Peters U.Drew D.A.Scherer D.Bermejo J.L.Williams A.C.Relton C.L. 2021 Cancer Epidemiology Biomarkers a Prevention. 30(3): 564-575.

DNA Repair Gene Polymorphisms and Chromosomal Aberrations in Exposed Populations.

Department of Molecular Biology of Cancer Niazi Y.Thomsen H.Smolková B.Vodičková L.Vodenková S.Kroupa M.Vymetálková V.Kazimírová A.Barancoková M.Volkovová K.Staruchová M.Hoffmann P.Noethen M.M.Dusinska M.Musak L.Vodička P.Hemminki K.Foersti A. 2021 Frontiers in Genetics. 12: 691947.

DNA repair gene polymorphisms and chromosomal aberrations in healthy, nonsmoking population.

Department of Molecular Biology of Cancer Niazi Y.Thomsen H.Smolková B.Vodičková L.Vodenková S.Kroupa M.Vymetálková V.Kazimírová A.Barancoková M.Volkovová K.Staruchová M.Hoffmann P.Noethen M.Dusinská M.Musak L.Vodička P.Foersti A.Hemminki K. 2021 DNA Repair. 101: 103079.

Telomere length in peripheral blood lymphocytes related to genetic variation in telomerase, prognosis and clinicopathological features in breast cancer patients.

Department of Molecular Biology of Cancer Department of Toxicology and Molecular Epidemiology Kroupa M.Rachakonda S.Vymetálková V.Tomášová K.Liška V.Vodenková S.Čumová A.Rössnerová A.Vodičková L.Hemminki K.Souček P.Kumar R.Vodička P. 2020 Mutagenesis. 35(6):491-497.

Genetic architectures of proximal and distal colorectal cancer are partly distinct.

Department of Molecular Biology of Cancer Huyghe J.R.Harrison T.A.Bien S.A.Hampel H.Figueiredo J.C.Schmit S.L.Conti D.V.Chen S.Qu C.Lin Y.Barfield R.Baron J.A.Cross A.J.Diergaarde B.Duggan D.Harlid S.Imaz L.Kang H.M.Levine D.M.Perduca V.Perez-Cornago A.Sakoda L.C.Schumacher F.R.Slattery M.L.Toland A.E.van Duijnhoven F.J.B.Van Guelpen B.Agudo A.Albanes D.Alonso M.H.Anderson K.Arnau-Collell C.Arndt V.Banbury B.L.Bassik M.C.Berndt S.I.Bézieau S.B.Bishop D.T.Boehm J.Boeing H.Boutron-Ruault M.-C.Brenner H.Brezina S.Buch S.Buchanan D.D.Burnett-Hartman A.Caan B.J.Campbell P.T.Carr P.R.Castells A.Castellví-Bel S.Chan A.T.Chang-Claude J.Chanock S.J.Curtis K.R.de la Chapelle A.Easton D.F.English D.R.Feskens E.J.M.Gala M.Gallinger S.J.Gauderman W.J.Giles G.G.Goodman P.J.Grady W.M.Grove J.S.Gsur A.Gunter M.J.Haile R.W.Hampe J.Hoffmeister M.Hopper J.L.Hsu W.-L.Huang W.-Y.Hudson T.J.Jenab M.Jenkins M.A.Joshi A.D.Keku T.O.Kooperberg C.Kühn T.Küry S.Le Marchand L.Lejbkowicz F.Li C.I.Li L.Lieb W.Lindblom A.Lindor N.M.Männistö S.Markowitz S.D.Milne R.L.Moreno L.Murphy N.Nassir R.Offit K.Ogino S.Panico S.Parfrey P.S.Pearlman R.Pharoah P.D.P.Phipps A.I.Platz E.A.Potter J.D.Prentice R.L.Qi L.Raskin L.Rennert G.Rennert H.S.Riboli E.Schafmayer C.Schoen R.E.Seminara D.Song M.Su Y.-R.Tangen C.M.Thibodeau S.N.Thomas D.C.Trichopoulou A.Ulrich C.M.Visvanathan K.Vodička P.Vodičková L.Vymetálková V.Weigl K.Weinstein S.J.White E.Wolk A.Woods M.O.Wu A.H.Abecasis G.R.Nickerson D.A.Scacheri P.C.Kundaje A.Casey G.Gruber S.B.Hsu L.Moreno V.Hayes R.B.Newcomb P.A.Peters U. 2021 Gut. 70(7): 1325-1334.

Identifying novel susceptibility genes for colorectal cancer risk from a transcriptome-wide association study of 125,478 subjects.

Department of Molecular Biology of Cancer Guo X.Lin W.Wen W.Huyghe J.Bien S.Cai Q.Harrison T.Chen Z.Qu C.Bao J.Long J.Yuan Y.Wang F.Bai M.Abecasis G.R.Albanes D.Berndt S.I.Bézieau S.Bishop D.T.Brenner H.Buch S.Burnett-Hartman A.Campbell P.T.Castellví-Bel S.Chan A.T.Chang-Claude J.Chanock S.J.Cho S.H.Conti D.V.de la Chapelle A.Feskens E.J.M.Gallinger S.J.Giles G.G.Goodman P.J.Gsur A.Guinter M.Gunter M.J.Hampe J.Hampel H.Hayes R.B.Hoffmeister M.Kampman E.Kang H.M.Keku T.O.Kim H.R.Le Marchand L.Lee S.C.Li C.I.Li L.Lindblom A.Lindor N.Milne R.L.Moreno V.Murphy N.Newcomb P.A.Nickerson D.A.Offit K.Pearlman R.Pharoah P.D.P.Platz E.A.Potter J.D.Rennert G.Sakoda L.C.Schafmayer C.Schmit S.L.Schoen R.E.Schumacher F.R.Slattery M.L.Su Y.-R.Tangen C.M.Ulrich C.M.van Duijnhoven F.J.B.van Guelpen B.Visvanathan K.Vodička P.Vodičková L.Vymetálková V.Wang X.White E.Wolk A.Woods M.O.Casey G.Hsu L.Jenkins M.A.Gruber S.B.Peters U.Zheng W. 2021 Gastroenterology. 160(4) 1164–1178.

Polygenic and multifactorial scores for pancreatic ductal adenocarcinoma risk prediction.

Department of Molecular Biology of Cancer Galeotti A.A.Gentiluomo M.Rizzato C.Obazee O.Neoptolemos J.P.Pasquali C.Nentwich M.Cavestro G.M.Pezzilli R.Greenhalf W.Holleczek B.Schroeder C.Schöttker B.Ivanauskas A.Ginocchi L.Key T.J.Hegyi P.Archibugi L.Darvasi E.Basso D.Sperti C.Bijlsma M.F.Palmieri O.Hlaváč V.Talar-Wojnarowská R.Mohelniková-Duchoňová B.Hackert T.Vashist Y.Strouhal O.Laarhoven H.Tavano F.Loveček M.Dervenis Ch.Izbéki F.Padoan A.Małecka-Panas E.Maiello E.Vanella G.Capurso G.Izbicki J.R.Theodoropoulos G.E.Jamroziak K.Katzke V.Kaaks R.Mambrini A.Papanikolaou I.S.Szmola R.Szentesi A.Kupcinskas J.Bursi S.Costello E.Boggi U.Milanetto A.C.Landi S.Gazouli M.Vodičková L.SoučekGioffreda D.Gemignani D.Brenner H.Strobel O.Büchler M.Vodička P.Paiella S.Canzian F.Campa D. 2021 Journal of Medical Genetics. 58(6): 369-377.

Genetic variations in 3'UTRs of SMUG1 and NEIL2 genes modulate breast cancer risk, survival and therapy response.

Department of Molecular Biology of Cancer Čumová A.Vymetálková V.Opattová A.Boušková V.Pardini B.Kopečkov K.Kozevnikovová R.Licková K.Ambrus M.Vodičková L.Naccarati A.Souček P.Vodička P. 2021 Mutagenesis. 36(4): 269-279.

Local Immune Changes in Early Stages of Inflammation and Carcinogenesis Correlate with the Collagen Scaffold Changes of the Colon Mucosa.

Department of Molecular Biology of Cancer Čaja F.Stakheev D.Chernyavskiy O.Kubinová L.Krizan J.Dvořák J.Rossmann P.Štěpánková R.Makovický P.Makovický P.Vymetálková V.Souček P.Vodička P.Vodičková L.Levý M.Vannucci L. 2021 Cancers. 13(10): 2463.

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study.

Department of Molecular Biology of Cancer Bull C.J.Bell J.A.Murphy N.Sanderson E.Smith G.D.Timpson N.J.Banbury B.L.Albanes D.Berndt S.I.Bezieau S.Bishop D. T.Brenner H.Buchanan D.D.Burnett-Hartman A.Casey G.Castellvi-Bel S.Chan A.Chang-Claude J.Cross A.J.de la Chapelle A.Figueiredo J.C.Gallinger S. J.Gapstur S.M.Giles G.G.Gruber S.B.Gsur A.Hampe J.Hampel H.Harrison T.A.Hoffmeister M.Hsu L.Huang W.Y.Huyghe J.R.Jenkins M. A.Joshu C.E.Keku T.O.Kuhn T.Kweon S.S.Le Marchand L.Li Ch.S.I.Li L.Lindblom A.Martin V.May A.M.Milne R.L.Moreno V.Newcomb P.A.Offit K.Ogino S.Phipps A.I.Platz E.A.Potter J.D.Qu C.Quiros J. R.Rennert G.Riboli E.Sakoda L.C.Schafmayer C.Schoen R.E.Slattery M.L.Tangen C.M.Tsilidis K.K.Ulrich C.M.van Duijnhoven F.J.B.van Guelpen B.Visvanathan K.Vodička P.Vodičková L.Wang H.S.White E.Wolk A.Woods M.O.Wu A.H.Campbell P.T.Zheng W.Peters U.Vincent E.E.Gunter M.J. 2020 BMC Medicine. 18(1): 396.

Genetic variations in microRNA-binding sites of solute carrier transporter genes as predictors of clinical outcome in colorectal cancer.

Department of Molecular Biology of Cancer Bendová P.Pardini B.Susová S.Rosendorf J.Levy M.Skrobánek P.Buchler T.Král J.Liska V.Vodičková L.Landi S.Souček, P.Naccarati A.Vodička P.Vymetálková V. 2021 Carcinogenesis. 42(3): 378-394.

The dynamics of telomere length in primary and metastatic colorectal cancer lesions

Department of Molecular Biology of Cancer Kroupa M.Kubecek O.Tomášová K.Hanák P.Krupová M.Červená K.Šišková A.Rosendorf J.Hosek P.Vodičková L.Vodička P.Liška V.John S.Vymetálková V.Petera J. 2023 Sci Rep . 2023 Jun 5;13(1):9097. doi: 10.1038/s41598-023-35835-9.

Differences in genome, transcriptome, miRNAome, and methylome in synchronous and metachronous liver metastasis of colorectal cancer

Department of Molecular Biology of Cancer Department of Toxicology and Molecular Epidemiology Horák J.Kubecek O.Šišková A.Hoňková K.Chvojková I.Krupova M.Manethova M.Vodenková S.García-Mulero S.John S.Cecka F.Vodičková L.Petera J.Filip S.Vymetálková V. 2023 Front Oncol . 2023 Apr 27;13:1133598. doi: 10.3389/fonc.2023.1133598. eCollection 2023.

MUC13-miRNA-4647 axis in colorectal cancer: Prospects to identifications of risk factors and clinical outcomes.

Department of Molecular Biology of Cancer Sojka L.Opattová A. Bartů L.Horák J.Kořenková V.Novosadová V.Krížková V.Bruha J.Liška V.Schneiderová M.Kubecek O.Vodičková L.Urbanová M.Simsa J.Vodička P.Vymetálková V. 2023 Oncology Letters. 25 (2): 72.

An investigation of DNA damage and DNA repair in chemical carcinogenesis triggered by small-molecule xenobiotics and in cancer: Thirty years with the comet assay.

Department of Molecular Biology of Cancer Vodička P.Vodenková S.Horák J.Opattová A.Tomášová K.Vymetálková V.Stetina R.Hemminki K.Vodičková L. 2023 Mutation Research – Genetic Toxicology and Environmental Mutagenesis. 885: 503564.

Truncated PPM1D impairs response to genotoxic stress and promotes growth of APCmin induced tumors in mouse colon.

Department of Molecular Biology of Cancer Burocziová M.Burdová K.Vieru A.S.Kasparek P.Kleiblová P.Danielsen S.A.Zemanková P.Jeniková G.Pavel J.Tichá I.Xiao-Feng S.Janečková L.Borecká M.Schneiderová M.Schwarzová L.Vodičková L.Vodička P.Jirásková K.Liska V.Sedláček R.Kleibl Z.Ragenhild L.Kořínek V.Macurek L. 2019 Cell Death and Disease. 10: 818.

Genetic determinants of telomere length and risk of pancreatic cancer: a PANDoRA study.

Department of Molecular Biology of Cancer Campa D.Matarazzi M.Greenhalf W.Bijlsma M.Saum K.U.Pasquali C.van Laarhoven H.Szentesi A.Federici F.Vodička P.Vodička P.Funel N.Pezzilli R.Bueno-de-Mesquita H. B.Vodičková L.Basso D.Obazee O.Hackert T.Souček P.Cuk K.Kaiser J.Sperti C.Loveček M.Capurso G.Mohelníková-Duchoňová B.Khaw K. T.König A.K.Kupcinskas J.Kaaks R.Bambi F.Archibugi L.Mambrini A.Cavestro G.M.Landi S.Hegyi P.Izbicki J.R.Gioffreda D.Zambon C.F.Tavano F.Talar-Wojnarowska R.Jamroziak K.Key T. J.Fave G.D.Strobel O.Jonaitis L.Andriulli A.Lawlor R.T.Pirozzi F.Katzke V.Valsuani Ch.Vashist Y.K.Brenner H.Canzian F. 2019 International Journal of Cancer. 144 (6):1275-1288.