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    Publications of the IEM CAS in 2024

    PublicationResearch Published on 04. 12. 2024 Reading time Reading time: 3 minutes

    At the end of the year, it is time to look back and reflect. This year, the scientists from the IEM CAS have published a total of 86 studies that have contributed to the development of scientific knowledge and which prove the excellence of our research.

    The Department of Molecular Biology of Cancer has the most publications to its credit – a total of 21 papers with a total IF of 206.4. In the overall evaluation, which is based on a number of criteria and a special recalculation, the most successful departments are:

    1. Department of Toxicology and Molecular Epidemiology
    2. Department of Cellular Neurophysiology
    3. Department of Molecular Biology of Cancer

    We congratulate all authors and thank them for their contribution not only to our institution but to the entire scientific community.

    Awarded publications

    with a high contribution from the IEM CAS

    • Líbalová, H., Závodná, T., Elzeinová, F., Barošová, H., Červená, T., Milcová, A., Vaňková, J., Paradeisi, F., Vojtisek-Lom, M., Sikorová, J., Topinka, J., Rössner, P.: (2023) The Genotoxicity of Organic Extracts from Particulate Emissions Produced by Neat Gasoline (E0) and a Gasoline-Ethanol Blend (E15) in BEAS-2B Cells. Journal of xenobiotics. 14(1): 1–14.
    • Fabbri, R., Scidà, A., Saracino, E., Conte, G., Kovtun, A., Candini, A., Kirdajová, D., Spennato, D., Marchetti, V., Lazzarini, C., Konstantoulaki, A., Dambruoso, P., Caprini, M., Muccini, M., Ursino, M., Anděrová, M., Treossi, E., Zamboni, R., Palermo, V., Benfenati, V.: (2024) Graphene oxide electrodes enable electrical stimulation of distinct calcium signalling in brain astrocytes. Nature nanotechnology. 19(9): 1344–1353.
    • Kaplan M. M., Hudáčová, E., Matějček, M., Tuaima, H., Křiivánek, J., Machoň, O.: (2024) Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation. eLife. Reviewed preprint (not revised)
    • Saveleva, L.,Cervena, T., Mengoni, C., Sima, M., Krejcik, Z., Vrbova, K.,Sikorova, J.,Mussalo, L., de Crom, T.O.E., Šímová, Z.,  Ivanova, M., Ali Shahbaz, M., Penttilä, E., Löppönen, H., Koivisto, A.M., Arfan Ikram, M., Jalava, P., Malm, T., Chew, S., Vojtisek-Lom, M., Topinka, J., Giugno, R., Rössner, P., Kanninen, K.M.: (2024) Transcriptomic and epigenomic profiling reveals altered responses to diesel emissions in Alzheimer’s disease both in vitro and in population-based data. Alzheimers and Dementia. Online ahead of print.
    • Misiachna, A., Konecny, J., Kolcheva, M., Ladislav, M., Prchal, L., Netolický, J., Kortus, S., Zahumenská, P., Langore, E., Novak, M., Hemelíková, K., Heřmanová, Z., Hrochová, M., Pelikanová, A., Odvarkova, J., Pejchal, J., Kassa, J., Zdarova Karasova, J., Korabecny, J., Soukup, O., Horák, M.: (2024) Potent and reversible open-channel blocker of NMDA receptor derived from dizocilpine with enhanced membrane-to-channel inhibition. Biomedicine & pharmacotherapy. 178: 117201.
    • Šíma, M., Líbalová, H., Závodná, T., Vrbová, K., Kléma, J., Rössner, P.: (2024) Gene expression profiles and protein-protein interaction networks in THP-1 cells exposed to metal-based nanomaterials. Environmental toxicology and pharmacology. 108: 104469.

    with high normalised IF

    • Laskar, R. S., Qu, C., Huyghe, J. R., Harrison, T., Hayes, R. B., Cao, Y., Campbell, P. T., Steinfelder, R., Talukdar, F. R., Brenner, H., Ogino, S., Brendt, S., Bishop, D. T., Buchanan, D. D., Chan, A. T., Cotterchio, M., Gruber, S. B., Gsur, A., van Guelpen, B., Jenkins, M. A., Keku, T.O., Lynch, B.M., Le Marchand, L., Martin, R.M., McCarthy, K., Moreno, V., Pearlman, R., Song, M., Tsilidis, K.K., Vodička, P., Woods, M.O., Wu, K., Hsu, L., Gunter, M.J., Peters, U., Murphy, N.: (2024) Genome-wide association studies and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer. Annals of oncology : official journal of the European Society for Medical Oncology. 35(6): 523–536.
    • Fabbri, R., Scidà, A., Saracino, E., Conte, G., Kovtun, A., Candini, A., Kirdajová, D., Spennato, D., Marchetti, V., Lazzarini, C., Konstantoulaki, A., Dambruoso, P., Caprini, M., Muccini, M., Ursino, M., Anděrová, M., Treossi, E., Zamboni, R., Palermo, V., Benfenati, V.: (2024) Graphene oxide electrodes enable electrical stimulation of distinct calcium signalling in brain astrocytes. Nature nanotechnology. 19(9): 1344–1353.
    • Schormair, B., Zhao, C., Bell, S., Didriksen, M., Nawaz, M. S., Schandra, N., Stefani, A., Högl, B., Dauvilliers, Y., Bachmann, C. G., Kemlink, D., Sonka, K., Paulus, W., Trenkwalder, C., Oertel, W. H., Hornyak, M., Teder-Laving, M., Metspalu, A., Hadjigeorgiou, G. M., Polo, O.,  Fietze, I., Ross, O.A., Wszolek, Z., Ibrahim, A., Bergmann, M., Kittke, V., Harrer. P, Dowsett, J., Chenini, S., Ostrowski, S. R., Sørensen, E., Erikstrup, C., Pedersen, O. B., Topholm, B. M., Nielsen, K. R., Butterworth, A. S., Soranzo, N., Ouwehand, W. H., Roberts, D. J., Danesh, J., Burchell, B., Furlotte, N. A., Nandakumar, P., 23andMe Research Team, D.E.S.I.R. study group, Earley, C. J., Ondo, W. G., Xiong, L., Desautels, A., Perola, M., Vodička, P., Dina,, C., Stoll, M., Franke, A., Lieb, W., Stewart, A. F. R., Shah, S. H., Gieger, C., Peters, A., Rye, D. B., Rouleau, G. A., Berger, K., Stefansson, H., Ullum, H., Stefansson, K., Hinds, D. A., Di Angelantonio, E., Oexle, K., Winkelmann, J.: (2024) Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction. Nature genetics. 56(6): 1090–1099.
    • Went, M., Duran-Lozano, L., Halldorsson, G. H., Gunnell, A., Ugidos-Damboriena, N., Law, P., Ekdahl, L., Sud, A., Thorleifsson, G., Thodberg, M., Olafsdottir, T., Lamarca-Arrizabalaga, A., Cafaro, C., Niroula, A., Ajore, R., Lopez de Lapuente Portilla, A., Ali, Z., Pertesi, M., Goldschmidt, H., Stefansdottir, L., Kristinsson, S. Y., Stacey, S. N., Love, T. J., Rognvaldsson, S., Hájek, R., Vodička, P., Pettersson-Kymmer, U., Späth, F., Schinke, C., Van Rhee, F., Sulem, P., Ferkingstad, E., Hjorleifsson Eldjarn, G., Mellqvist, U. H., Jonsdottir, I., Morgan, G., Sonneveld, P., Waage, A., Weinhold, N., Thomsen, H., Försti, A., Hansson, M., Juul-Vangsted, A., Thorsteinsdottir, U., Hemminki, K., Kaiser, M., Rafnar, T., Stefansson, K., Houlston, R., Nilsson, B.: (2024) Deciphering the genetics and mechanisms of predisposition to multiple myeloma. Nature communications. 15(1): 6644.
    • Chen, Z., Guo, X., Tao, R., Huyghe, J. R., Law, P. J., Fernandez-Rozadilla, C., Ping, J., Jia, G., Long, J., Li, C., Shen, Q., Xie, Y., Timofeeva, M. N., Thomas, M., Schmit, S. L., Díez-Obrero, V., Devall, M., Moratalla-Navarro, F., Fernandez-Tajes, J., Palles, C., Sherwood, K., Briggs, S.E.W., Svinti, V., Donnelly, K., Farrington, S.M., Blackmur, J., Vaughan-Shaw P.G., Shu, X.O., Lu, Y., Broderick, P., Studd, J., Harrison, T.A., Conti, D.V., Schumacher, F.R., Melas, M., Rennert, G., Obón-Santacana, M., Martín-Sánchez, V., Oh, J.H., Kim, J., Jee, S.H., Jung, K.J., Kweon, S.S., Shin, M.H., Shin, A., Ahn, Y.O., Kim, D.H., Oze, I., Wen, W., Matsuo, K., Matsuda, K., Tanikawa, C., Ren, Z., Gao, Y.T., Jia, W.H., Hopper, J.L., Jenkins, M.A., Win, A.K., Pai, R.K., Figueiredo, J.C., Haile, R.W., Gallinger, S., Woods, M.O., Newcomb, P.A., Duggan, D., Cheadle, J.P., Kaplan, R., Kerr, R., Kerr, D., Kirac, I., Böhm, J., Mecklin, J.P., Jousilahti, P., Knekt, P., Aaltonen, L.A., Rissanen, H., Pukkala, E., Eriksson, J.G., Cajuso, T., Hänninen, U., Kondelin, J., Palin, K., Tanskanen, T., Renkonen-Sinisalo, L., Männistö, S., Albanes, D., Weinstein, S.J., Ruiz-Narvaez, E., Palmer, J.R., Buchanan, D.D., Platz, E.A., Visvanathan, K., Ulrich, C.M., Siegel, E., Brezina, S., Gsur, A., Campbell, P.T., Chang-Claude, J., Hoffmeister, M., Brenner, H., Slattery, M.L., Potter, J.D., Tsilidis, K.K., Schulze, M.B., Gunter, M.J., Murphy, N., Castells, A., Castellví-Bel, S., Moreira, L., Arndt, V., Shcherbina, A., Bishop, D.T., Giles, G.G., Southey, M.C., Idos, G.E., McDonnell, K.J., Abu-Ful, Z., Greenson, J.K., Shulman, K., Lejbkowicz, F., Offit, K., Su, Y.R., Steinfelder, R., Keku, T.O., van Guelpen, B., Hudson, T.J., Hampel. H., Pearlman, R., Berndt, S.I., Hayes, R.B., Martinez, M.E., Thomas, S.S., Pharoah, P.D.P., Larsson, S.C., Yen, Y., Lenz, H.J., White, E., Li, L., Doheny, K.F., Pugh, E., Shelford, T., Chan, A.T., Cruz-Correa, M., Lindblom, A., Hunter, D.J., Joshi, A.D., Schafmayer, C., Scacheri, P.C., Kundaje, A., Schoen, R.E., Hampe, J., Stadler, Z.K., Vodička, P., Vodičková, L., Vymetálková, V., Edlund, C.K., Gauderman, W.J., Shibata, D., Toland, A., Markowitz, S., Kim, A., Chanock, S.J., van Duijnhoven, F., Feskens, E.J.M., Sakoda, L.C., Gago-Dominguez, M., Wolk, A., Pardini, B., FitzGerald, L.M., Lee, S.C., Ogino, S., Bien, S.A., Kooperberg, C., Li, C.I., Lin, Y., Prentice, R., Qu, C., Bézieau, S., Yamaji, T., Sawada. N, Iwasaki, M., Le Marchand, L., Wu, A.H., Qu, C., McNeil, C.E., Coetzee, G., Hayward, C., Deary, I.J., Harris, S.E., Theodoratou, E., Reid, S., Walker, M., Ooi, L.Y., Lau, K.S., Zhao, H., Hsu, L., Cai, Q., Dunlop, M.G., Gruber, S.B., Houlston, R.S., Moreno, V., Casey, G., Peters, U., Tomlinson, I., Zheng, W.: (2024) Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes. Nature communications. 15(1): 3557.
    • Elblová, P., Lunova, M., Henry, S. J. W., Tu, X., Calé, A., Dejneka, A., Havelková, J., Petrenko, Y., Jirsa, M., Stephanopoulos, N., Lunov, O.: (2024) Peptide-coated DNA nanostructures as a platform for control of lysosomal function in cells. Chemical engineering journal. 498: 155633.
    • Saveleva, L.,Cervena, T., Mengoni, C., Sima, M., Krejcik, Z., Vrbova, K.,Sikorova, J.,Mussalo, L., de Crom, T.O.E., Šímová, Z.,  Ivanova, M., Ali Shahbaz, M., Penttilä, E., Löppönen, H., Koivisto, A.M., Arfan Ikram, M., Jalava, P., Malm, T., Chew, S., Vojtisek-Lom, M., Topinka, J., Giugno, R., Rössner, P., Kanninen, K.M.: (2024) Transcriptomic and epigenomic profiling reveals altered responses to diesel emissions in Alzheimer’s disease both in vitro and in population-based data. Alzheimers and Dementia. Online ahead of print.
    • Carnicer-Lombarte, A., Barone, D. G., Wronowski, F., Malliaras, G. G., Fawcett, J. W., Franze, K.: (2023) Regenerative capacity of neural tissue scales with changes in tissue mechanics post injury. Biomaterials. 303: 122393.
    • Thomsen, H., Chattopadhyay, S., Weinhold, N., Vodička, P., Vodičková, L., Hoffmann, P., Nöthen, M. M., Jöckel, K. H., Schmidt, B., Hajek, R., Hallmans, G., Pettersson-Kymmer, U., Späth, F., Goldschmidt, H., Hemminki, K., Försti, A.: (2024) Haplotype analysis identifies functional elements in monoclonal gammopathy of unknown significance. Blood cancer journal. 14(1): 140.
    • Guo, X., Ping, J., Yang, Y., Su, X., Shu, X. O., Wen, W., Chen, Z., Zhang, Y., Tao, R., Jia, G., He, J., Cai, Q., Zhang, Q., Giles, G. G., Pearlman, R., Rennert, G., Vodička, P., Phipps, A., Gruber, S. B., Casey, G., Peters, U., Long, J., Lin, W., Zheng, W.: (2024) Large-Scale Alternative Polyadenylation-Wide Association Studies to Identify Putative Cancer Susceptibility Genes. Cancer research. 84(16): 2707–2719.
    • Mussalo, L., Lampinen, R., Avesani, S., Závodná, T., Krejčík, Z., Kalapudas, J., Penttilä, E., Löppönen, H., Koivisto, A. M., Malm, T., Topinka, J., Giugno, R., Jalava, P., Kanninen, K. M.: (2024) Traffic-related ultrafine particles impair mitochondrial functions in human olfactory mucosa cells, Implications for Alzheimer’s disease. Redox biology. 75: 103272.
    • Zucha, D., Abaffy, P., Kirdajová, D., Jirak, D., Kubista, M., Anděrová, M., Valihrach, L.: (2024) Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia. Proceedings of the National Academy of Sciences of the United States of America. 121(46): e2404203121.