Institute of Experimental Medicine CAS

The Department of Neurochemistry studies molecular mechanisms that regulate the function of glutamate receptors in the mammalian central nervous system. We also aim to develop novel pharmacological compounds that act on glutamate receptors for the treatment of cognitive decline caused by neurodegeneration. Our experimental approach includes microscopy, biochemistry, and electrophysiology in cultured hippocampal neurones and human fibroblasts derived from patients with neurodegenerative diseases. Our long-term goal is to develop “personalised” compounds for treating specific neurodegenerative conditions including Alzheimer disease.

img-7630 From the left: Marharyta Kolcheva, Kristýna Skřenková, Štěpán Kortus, Martin Horák, Martina Kaniaková, Barbora Krausová, Anna Misiachna.

Deputy Head:

Kristýna Skřenková, MSc
E-mail: kristyna.skrenkova@iem.cas.cz

Research Scientists:

Martin Horák, Ph.D. 
Paula Rivas Ramirez, Ph.D. 
Štěpán Kortus, Ph.D. 

PhD. Students:

Marharyta Kolcheva, MSc 
Jakub Netolický, MSc
Anna Misiachna, MSc 
Kristýna Skřenková, MSc

Lab Manager:

Petra Baráčková, MSc 

2019

Skrenkova KHemelikova KKolcheva MKortus SKaniakova M, Krausova BHorak M. Structural features in the glycine-binding sites of the GluN1 and GluN3A subunits regulate the surface delivery of NMDA receptorsScientific reports 9:12303. 

Hemelikova KKolcheva MSkrenkova KKanikova MHorak MLectins modulate the functional properties of GluN1/GluN3A – containg receptorsNeuropharmacology 157, 107671. 

Kaniakova M , Nepovinova E, Kleteckova L, Skrenkova K, Chrienova Z, Hepnarova V, Vales K, Soukup O, Korabecny J*, Horak M*. Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer’s Disease. Current Alzheimer Research

2018

Kaniakova M , Kleteckova L, Lichnerova K, Holubova K, Skrenkova K, Korinek M, Krusek J, Smejkalova T, Korabecny J, Vales K, Soukup O, Horak M*. 7-Methoxyderivative of tacrine is a 'foot-in-the-door' open-channel blocker of GluN1/GluN2 and GluN1/GluN3 NMDA receptors with neuroprotective activity in vivo. Neuropharmacology. 2018;140:217-232. 

Skrenkova K , Lee S, Lichnerova K, Kaniakova M, Hansikova H, Zapotocky M, Suh YH*, Horak M*. N-Glycosylation Regulates the Trafficking and Surface Mobility of GluN3A-Containing NMDA Receptors. Front Mol Neurosci. 2018 Jun 4;11:188. 

Delineating the mechanisms that regulate specific NMDA receptor subtypes in mammalian neurones
GAČR,  20-12420S, 2020-2023

Novel neuroprotective compounds based on NMDA receptor antagonism and cholinergic stimulation
GAČR,  20-12047S, 2020-2023

National Institute of Mental Health, Klecany

Biomedical Research Center, Hradec Kralove

Neuroscience Research Institute, Seoul National University College of Medicine, Republic of Korea

Mail room:
building La 2. floor, room 2.18
Mo–Fri   9:00–13:00

Data box:
kqcnc2p

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Contacts

Vídeňská 1083
142 20 Praha 4-Krč
Czech Republic
+420 241 062 230