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Cell Nucleus Plasticity

Research Department

Group photo of the Department of Cell Nucleus Plasticity team

The department is focused on the research of the early embryogenesis of mammals and the change in the plasticity of the cell nucleus, which accompanies the process of differentiation and dedifferentiation. These processes are accompanied by a significant change in the morphology of the nuclei and epigenetic remodeling of chromatin. The aim of the department is to characterize the influence of individual nuclear components and to define the role of subnuclear organelles in this process. Currently, the department‘s research focuses on the mechanism and role of active demethylation of the paternal genome after fertilization. Another topic is the impact of A‑ and B-type nuclear lamin depletion on early development.

Helena Fulková

Head of the Department
Helena Fulková, Ph.D.

Telefonní číslo +420 241 062 232
Mailová adresa helena.fulkova@iem.cas.cz
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People

Researchers

Pavel Čabart, Ph.D.

Tereza Ilčíková, M.Sc.

Natálie Novotná, M.Sc.

Ondřej Peller, B.Sc.

Tereza Znachorová, M.Sc.

PhD Students

Nataliia Dudko, MSc.

Important Results


Nuclear lamins play a key role in mammalian development

Nuclear lamins are key nuclear proteins and at least one member of this family of proteins is detectable in the nucleus of the majority of cells. However, althought this might indicate that nuclear lamins are encoded by esential genes at the cellular level, their role especially in development remains highly controversial.

Lamin AC in early embryos. The presence of lamin AC has been traditionally linked to an advanced differentiation of cells. However, it is paradoxically also clearly detectable in mouse zygotes, which are totipotent.

 

Publication:

Paul, J.Ch., Fulka, H.: (2022) Nuclear Lamins: Key Proteins for Embryonic Development. Biology-Basel. 11(2): 198. doi: 10.3390/biology11020198. PMID: 35205065


Projects

Provider

Year

1. 3. 2022 – 28. 2. 2025

Molecular and functional analysis of the nucleolus in 3D genome organization during early embryo development

GAČR ve spolupráci Swiss National Science Foundation
2021–2024

Genome stability in mammalian oocytes and somatic cells

Publications

25th ANNIVERSARY OF CLONING BY SOMATIC-CELL NUCLEAR TRANSFER Scientific and technological approaches to improve SCNT efficiency in farm animals and pets.

 DepartmentDepartment of Cell Nucleus Plasticity AutořiLoi P.Palazzese L.Scapolo P.A.Fulka J. Jr.Fulka H.Czernik M. Published on 2021 Metadata Reproduction. 162(1): F33-F43.

De novo emergence, existence, and demise of a protein-coding gene in murids.

 DepartmentDepartment of Cell Nucleus Plasticity AutořiPetržílek J.Pasulka J.Malík R.Horvat F.Kataruka S.Fulka H.Fulka H.Svoboda P. Published on 2022 Metadata BMC BIOLOGY. 20(1): 272.

Formation of spermatogonia and fertile oocytes in golden hamsters requires piRNAs.

 DepartmentDepartment of Cell Nucleus Plasticity AutořiLoubalová Z.Fulka H.Horvat F.Pasulka J.Malik R.Hirose M.Ogura A.Svoboda P. Published on 2021 Metadata Nature Cell Biology. 23(9): 992-1021.

Interspecific ICSI for the Assessment of Sperm DNA Damage: Technology Report.

 DepartmentDepartment of Cell Nucleus Plasticity AutořiRychtařová J.Langerová A.Fulka H.Loi P.Benc M.Fulka J. Jr. Published on 2021 Metadata Animals. 11(5): 1250.

Nuclear Lamins: Key Proteins for Embryonic Development.

 DepartmentDepartment of Cell Nucleus Plasticity AutořiPaul J.Ch.Fulka H. Published on 2022 Metadata Biology-Basel. 11(2): 198.

Nucleus reprogramming/remodeling through selective enucleation (SE) of immature oocytes and zygotes: a nucleolus point of view.

 DepartmentDepartment of Cell Nucleus Plasticity AutořiFulka H.Loi P.Palazzese L.Benc M.Fulka J. Published on 2022 Metadata Journal of Reproduction and Development. 68(3): 165-172.

Omne vivum ex ovo: the oocyte reprogramming and remodeling activities.

 DepartmentDepartment of Cell Nucleus Plasticity AutořiFulka H.Loi P.Czernik M.Surani A.Fulka Jr. J. Published on 2023 Metadata Reproduction. 165(3): R75-R89.

Collaborators