Institute of Experimental Medicine CAS

In our Department we investigate molecular characteristics of solid cancers, especially of the colon, rectum, pancreas and ovaries. Within these studies we focus on the molecular epidemiological level in order 1. to identify biomarkers of increased predisposition to tumour diseases, 2. enable early diagnostics, 3. assess individual responses to anti-tumour treatment, 4. and determine long-term prognosis. The Department has been working with different types of biological material from a patients with cancer diseases, such as solid tissue, blood cells or plasma.


Deputy Head:

Veronika Vymetálková, MSc, PhD.
Phone: +420 241 062 699

Research Scientists:

Michal Kroupa, Ph.D.
Martin Mokrejš, Ph.D.
Alessio Naccarati, Ph,D.
Alena Opattová, PhD.
Soňa Vodenková, Ph.D.
Pavel Vodička, MD, PhD. 
Ludmila Vodičková, MD, PhD.
Veronika Vymetálková, MSc, PhD.

PhD. Students:

Petra Bendová, MSc
Klára Červená, MSc
Andrea Čumová, MSc
Josef Horák, MD
Jan Král, MD
Alexandra Rejhová, MSc
Kristýna Tomášová, MSc
Phone: +420 241 062 251

Undergraduate Students:

Ivana Fabianová
Dominika Vallušová, Bc

External Collaborators:

Jana Slyšková, Ph.D.
Markéta Urbanová, Ph.D.


Hana Vargošková

Important results in 2018

1. Analysis of the effect of functional genetic variants in DNA repair genes in relation to the risk of colorectal cancer

Results of the study of 16 genetic variants of DNA repair genes:

Identification of a single genetic polymorphism (rs3204953, the REV3L gene) associated with a 2.3-fold higher risk of disease for the carriers of variant genotype (p = 0.006) in association study.

Identification of variants rs3218649 in the gene POLQ and rs7689099 in the NEIL3 gene as significantly associated with overall survival (OS) and recurrent survival (RFS), using CART analysis.


Publication : Jiraskova, K., Hughes, D., Brezina, S., Gumpenberger, T., Veskrnova, V., Buchler, T., … Vodicka, P. (2018). Functional Polymorphisms in DNA Repair Genes Are Associated with Sporadic Colorectal Cancer Susceptibility and Clinical Outcome. International Journal of Molecular Sciences, 20(1), 97.


2. Base excision repair capacity as a determinant of prognosis and therapy response in colon cancer patients

Our results indicate that BER-DRC in non-malignant adjacent mucosa was positively associated with overall survival (P = 0.007) and relapse-free survival (P = 0.04). Additionally, in multivariate analysis, good therapy responders in TNM stage II and III with an elevated BER-DRC in mucosa exhibited better overall survival. Moreover, the overall survival of these patients was even better in the presence of a decreased BER-DRC in tumor tissue. The ratio of BER-DRC in tumor tissue over BER-DRC in mucosa positively correlated with advanced tumor stage (P = 0.003). 




Publication : Vodenkova, S., Jiraskova, K., Urbanova, M., Kroupa, M., Slyskova, J., Schneiderova, M., … Vodicka, P. (2018). Base excision repair capacity as a determinant of prognosis and therapy response in colon cancer patients. DNA Repair, 72, 77–85.


3. Expression profile of miR-17/92 cluster is predictive of treatment response in rectal cancer

We identified RC-specific miRNA signature that distinguishes responders from non-responders to adjuvant chemotherapy. A predominant part of identified miRNAs was represented by the members of miR-17/92 cluster. Upregulation of miRNA-17, -18a, -18b, -19a, -19b, -20a, -20b and -106a in tumor was associated with higher risk of tumor relapse and their overexpression in RC cell lines stimulated cellular proliferation. Examination of these miRNAs in plasma exosomes showed that their levels differed between RC patients and healthy controls and correlated with patient's treatment response. 


Publication : Kral, J., Korenkova, V., Novosadova, V., Langerova, L., Schneiderova, M., Liska, V., … Slyskova, J. (2018). Expression profile of miR-17/92 cluster is predictive of treatment response in rectal cancer. Carcinogenesis, 39(11), 1359–1367.


4. Discovery of common and rare genetic risk variants for colorectal cancer

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P< 5 × 10−8, bringing the number of known independent signals for CRC to ~100. New signals implicate lower-frequency variants, Krüppel-like factors, Hedgehog signaling, Hippo-YAP signaling, long noncoding RNAs and somatic drivers, and support a role for immune function. Heritability analyses suggest that CRC risk is highly polygenic, and larger, more comprehensive studies enabling rare variant analysis will improve understanding of biology underlying this risk and influence personalized screening strategies and drug development.



Publication:  Huyghe, J. R., Bien, S. A., Harrison, T. A., Kang, H. M., Chen, S., Schmit, S. L., … Peters, U. (2019). Discovery of common and rare genetic risk variants for colorectal cancer. Nature Genetics, 51(1), 76–87.



Important results in 2017

1. MicroRNA-binding site polymorphisms in genes involved in colorectal cancer etiopathogenesis as a predictive biomarkers for treatment of the disease

The CC genotype in rs8679 in PARP gene was associated with an increased risk of recurrence/progression in pacient. Carriers of at least on C allele were at a decreased risk of cancer (P = 0.005). Moreover the CC genotype in rs8679 was also associated with an increased risk of recurrence/progression in patients that received 5-FU-based chemotherapy (log-rank test P = 0.03).


Kaplan–Meier EFS curves in CRC patients undergoing 5-FU-based chemotherapy stratified for rs8679 in PARP1 gene.

Publication:  Michaela Schneiderova, Alessio Naccarati, Barbara Pardini, Fabio Rosa, Cornelia Di Gaetano, Katerina Jiraskova, Alena Opattova, Miroslav Levy, Karel Veskrna, Veronika Veskrnova, Tomas Buchler, Stefano Landi, Pavel Vodicka, Veronika Vymetalkova; MicroRNA-binding site polymorphisms in genes involved in colorectal cancer etiopathogenesis and their impact on disease prognosis, Mutagenesis, Volume 32, Issue 5, 17 October 2017, Pages 533-542,


2. The relative telomere length in peripheral lymphocytes may reflect the susceptibility to radiomimetics in colorectal cancer patient

We observed statistically significant increased level of chromosomal damage in CRC patients compared with controls after bleomycin treatment. Patients with shorter relative telomere length exhibited significantly higher amount of damage in peripheral lymphocytes after bleomycin treatment


Spearman correlation of relative telomere length and chromosomal damage in CRC patients and controls.

Publication: Kroupa M , Polivkova Z, Rachakonda S, et al. Bleomycin-induced chromosomal damage and shortening of telomeres in peripheral blood lymphocytes of incident cancer patients. Genes Chromosomes Cancer. 2018;57:61–69.


Important results in 2016

1. Polymorphisms in microRNA binding sites of mucin genes are significantly associated with the risk of colorectal cancer development and patient's survival

Patients carrying the CC genotype of rs886403 in MUC21 displayed a shorter survival and higher recurrence risk when compared with TT.

1 2 3

Publication: Veronika Vymetalkova , Barbara Pardini, Fabio Rosa, Katerina Jiraskova, Cornelia Di Gaetano, Petra Bendova, Miloslav Levy, Veronika Veskrnova, Tomas Buchler, Ludmila Vodickova, Alessio Naccarati, Pavel Vodicka; Polymorphisms in microRNA binding sites of mucin genes as predictors of clinical outcome in colorectal cancer patients, Carcinogenesis, Volume 38, Issue 1, 1 January 2017, Pages 28–39,


2. DNA methylation profiles of selected genes as biomarkers in rectal carcinogenesis

Analysis of methylation profile of paired samples of patient with rectal carcinoma (tumor tussue vs. adjacent mucosa) revealed aberrant methylation in 33 genes. This study has demonstrated the possibility of using specific methylated DNA profiles as diagnostic biomarkers in patients with rectal carcinoma.


Publication: Veronika Vymetalkova , Pavel Vodicka, Barbara Pardini, Fabio Rosa, Miroslav Levy, Michaela Schneiderova, Vaclav Liska, Ludmila Vodickova, Torbjörn K Nilsson, and Sanja A Farkas; Epigenome-wide analysis of DNA methylation reveals a rectal cancer-specific epigenomic signature, Epigenomics 2016 8:9, 1193-1207,



Vodenkova S, Kroupa M, Polivkova Z, Musak L, Ambrus M, Schneiderova M, Kozevnikovova R, Vodickova L, Rachakonda S, Hemminki K, Kumar R, Vodicka P. Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients. Oncol Rep. 2020 Nov;44(5):2219-2230. doi: 10.3892/or.2020.7774. Epub 2020 Sep 21. PMID: 33000239

Thomas M, Sakoda LC, Hoffmeister M, Rosenthal EA, Lee JK, van Duijnhoven FJB, Platz EA, Wu AH, Dampier CH, de la Chapelle A, Wolk A, Joshi AD, Burnett-Hartman A, Gsur A, Lindblom A, Castells A, Win AK, Namjou B, Van Guelpen B, Tangen CM, He Q, Li CI, Schafmayer C, Joshu CE, Ulrich CM, Bishop DT, Buchanan DD, Schaid D, Drew DA, Muller DC, Duggan D, Crosslin DR, Albanes D, Giovannucci EL, Larson E, Qu F, Mentch F, Giles GG, Hakonarson H, Hampel H, Stanaway IB, Figueiredo JC, Huyghe JR, Minnier J, Chang-Claude J, Hampe J, Harley JB, Visvanathan K, Curtis KR, Offit K, Li L, Le Marchand L, Vodickova L, Gunter MJ, Jenkins MA, Slattery ML, Lemire M, Woods MO, Song M, Murphy N, Lindor NM, Dikilitas O, Pharoah PDP, Campbell PT, Newcomb PA, Milne RL, MacInnis RJ, Castellví-Bel S, Ogino S, Berndt SI, Bézieau S, Thibodeau SN, Gallinger SJ, Zaidi SH, Harrison TA, Keku TO, Hudson TJ, Vymetalkova V, Moreno V, Martín V, Arndt V, Wei WQ, Chung W, Su YR, Hayes RB, White E, Vodicka P, Casey G, Gruber SB, Schoen RE, Chan AT, Potter JD, Brenner H, Jarvik GP, Corley DA, Peters U, Hsu L. Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk. Am J Hum Genet. 2020 Jul 29:S0002-9297(20)30236-6. doi: 10.1016/j.ajhg.2020.07.006. Online ahead of print. PMID: 32758450

Caja F, Vodickova L, Kral J, Vymetalkova V, Naccarati A, Vodicka P. DNA Mismatch Repair Gene Variants in Sporadic Solid Cancers. Int J Mol Sci. 2020 Aug 3;21(15):E5561. doi: 10.3390/ijms21155561. PMID: 32756484 Review.

Filip S, Vymetalkova V, Petera J, Vodickova L, Kubecek O, John S, Cecka F, Krupova M, Manethova M, Cervena K, Vodicka P. Distant Metastasis in Colorectal Cancer Patients-Do We Have New Predicting Clinicopathological and Molecular Biomarkers? A Comprehensive Review. Int J Mol Sci. 2020 Jul 24;21(15):E5255. doi: 10.3390/ijms21155255. PMID: 32722130 Review.

Kral J, Kojecky V, Stepan M, Vladarova M, Zela O, Knot J, Jakovljevic M, Kralova Z, Buresova R, Grega T, Bauman D, Kotyza J, Stepanova R, Hucl T, Vodicka P, Vodickova L, Spicak J. The experience with colorectal cancer screening in the Czech Republic: the detection at earlier stages and improved clinical outcomes.  Public Health. 2020 Jul 4;185:153-158. doi: 10.1016/j.puhe.2020.05.021. Online ahead of print. PMID: 32634606

Tomasova K, Cumova A , Seborova K, Horak J, Koucka K, Vodickova L, Vaclavikova R, Vodicka P. DNA Repair and Ovarian Carcinogenesis: Impact on Risk, Prognosis and Therapy Outcome. Cancers (Basel). 2020 Jun 28;12(7):E1713. doi: 10.3390/cancers12071713. PMID: 32605254

Cervena K, Siskova A , Buchler T, Vodicka P, Vymetalkova V. Methylation-Based Therapies for Colorectal Cancer. Cells. 2020 Jun 24;9(6):E1540. doi: 10.3390/cells9061540. PMID: 32599894 Review.

Galeotti AA, Gentiluomo M, Rizzato C, Obazee O, Neoptolemos JP, Pasquali C, Nentwich M, Cavestro GM, Pezzilli R, Greenhalf W, Holleczek B, Schroeder C, Schöttker B, Ivanauskas A, Ginocchi L, Key TJ, Hegyi P, Archibugi L, Darvasi E, Basso D, Sperti C, Bijlsma MF, Palmieri O, Hlavac V, Talar-Wojnarowska R, Mohelnikova-Duchonova B, Hackert T, Vashist Y, Strouhal O, van Laarhoven H, Tavano F, Lovecek M, Dervenis C, Izbéki F, Padoan A, Małecka-Panas E, Maiello E, Vanella G, Capurso G, Izbicki JR, Theodoropoulos GE, Jamroziak K, Katzke V, Kaaks R, Mambrini A, Papanikolaou IS, Szmola R, Szentesi A, Kupcinskas J, Bursi S, Costello E, Boggi U, Milanetto AC, Landi S, Gazouli M, Vodickova L, Soucek P, Gioffreda D, Gemignani F, Brenner H, Strobel O, Büchler M, Vodicka P, Paiella S, Canzian F, Campa D. Polygenic and multifactorial scores for pancreatic ductal adenocarcinoma risk prediction. J Med Genet. 2020 Jun 26:jmedgenet-2020-106961. doi: 10.1136/jmedgenet-2020-106961. Online ahead of print. PMID: 32591343

Siskova A, Cervena K , Kral J, Hucl T, Vodicka P, Vymetalkova V. Colorectal Adenomas-Genetics and Searching for New Molecular Screening Biomarkers. Int J Mol Sci. 2020 May 5;21(9). pii: E3260. doi: 10.3390/ijms21093260. Review. PubMed PMID: 32380676.

Campa D, Gentiluomo M, Obazee O, Ballerini A, Vodickova L, Hegyi P, Soucek P, Brenner H, Milanetto AC, Landi S, Gao X, Bozzato D, Capurso G, Tavano F, Vashist Y, Hackert T, Bambi F, Bursi S, Oliverius M, Gioffreda D, Schöttker B, Ivanauskas A, Mohelnikova-Duchonova B, Darvasi E, Pezzilli R, Małecka-Panas E, Strobel O, Gazouli M, Katzke V, Szentesi A, Cavestro GM, Farkas G Jr, Izbicki JR, Moz S, Archibugi L, Hlavac V, Vincze Á, Talar-Wojnarowska R, Rusev B, Kupcinskas J, Greenhalf B, Dijk F, Giese N, Boggi U, Andriulli A, Busch OR, Vanella G, Vodicka P, Nentwich M, Lawlor RT, Theodoropoulos GE, Jamroziak K, Zuppardo RA, Moletta L, Ginocchi L, Kaaks R, Neoptolemos JP, Lucchesi M, Canzian F. Genome-wide association study identifies an early onset pancreatic cancer risk locus. Int J Cancer. 2020 Apr 9. doi: 10.1002/ijc.33004. [Epub ahead of print] PubMed PMID:32270874.

Vodicka P, Urbanova M , Makovicky P, Tomasova K, Kroupa M, Stetina R, Opattova A, Kostovcikova K, Siskova A, Schneiderova M, Vymetalkova V, Vodickova L. Oxidative Damage in Sporadic Colorectal Cancer: Molecular Mapping of Base Excision Repair Glycosylases in Colorectal Cancer Patients. Int J Mol Sci. 2020 Apr 2;21(7). pii: E2473. doi: 10.3390/ijms21072473. Review. PubMed PMID:32252452; PubMed Central PMCID: PMC7177219.

Tomasova K, Kroupa M , Forsti A, Vodicka P, Vodickova L. Telomere maintenance in interplay with DNA repair in pathogenesis and treatment of colorectal cancer. Mutagenesis. 2020 Feb 21. pii: geaa005. doi: 10.1093/mutage/geaa005. [Epub ahead of print] PubMed PMID: 32083302.

Papadimitriou N, Dimou N, Tsilidis KK, Banbury B, Martin RM, Lewis SJ, Kazmi N, Robinson TM, Albanes D, Aleksandrova K, Berndt SI, Timothy Bishop D, Brenner H, Buchanan DD, Bueno-de-Mesquita B, Campbell PT, Castellví-Bel S, Chan AT, Chang-Claude J, Ellingjord-Dale M, Figueiredo JC, Gallinger SJ, Giles GG,
Giovannucci E, Gruber SB, Gsur A, Hampe J, Hampel H, Harlid S, Harrison TA, Hoffmeister M, Hopper JL, Hsu L, María Huerta J, Huyghe JR, Jenkins MA, Keku TO, Kühn T, La Vecchia C, Le Marchand L, Li CI, Li L, Lindblom A, Lindor NM, Lynch B, Markowitz SD, Masala G, May AM, Milne R, Monninkhof E, Moreno L, Moreno V, Newcomb PA, Offit K, Perduca V, Pharoah PDP, Platz EA, Potter JD, Rennert G, Riboli E, Sánchez MJ, Schmit SL, Schoen RE, Severi G, Sieri S, Slattery ML, Song M, Tangen CM, Thibodeau SN, Travis RC, Trichopoulou A, Ulrich CM, van Duijnhoven FJB, Van Guelpen B, Vodicka P, White E, Wolk A, Woods MO, Wu AH, Peters U, Gunter MJ, Murphy N. Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis. Nat Commun. 2020 Jan 30;11(1):597. doi:10.1038/s41467-020-14389-8. PubMed PMID: 32001714.

Vymetalkova V , Rosa F, Susova S, Bendova P, Levy M, Buchler T, Kral J, Bartu L, Vodickova L, Hughes DJ, Soucek P, Naccarati A, Kumar R, Vodicka P, Pardini B.  Expression quantitative trait loci in ABC transporters are associated with survival in 5-FU treated colorectal cancer patients. Mutagenesis. 2020 Jan 10.
pii: gez050. doi: 10.1093/mutage/gez050. [Epub ahead of print] PubMed PMID:31922572.


Murphy N, Carreras-Torres R, Song M, Chan AT, Martin RM, Papadimitriou N, Dimou N, Tsilidis KK, Banbury B, Bradbury KE, Besevic J, Rinaldi S, Riboli E, Cross AJ, Travis RC, Agnoli C, Albanes D, Berndt SI, Bézieau S, Bishop DT, Brenner H, Buchanan DD, Onland-Moret NC, Burnett-Hartman A, Campbell PT, Casey G,
Castellví-Bel S, Chang-Claude J, Chirlaque MD, Chapelle A, English D, Figueiredo JC, Gallinger SJ, Giles GG, Gruber SB, Gsur A, Hampe J, Hampel H, Harrison TA, Hoffmeister M, Hsu L, Huang WY, Huyghe JR, Jenkins MA, Keku TO, Kühn T, Kweon SS, Le Marchand L, Li CI, Li L, Lindblom A, Martín V, Milne RL, Moreno V, Newcomb PA, Offit K, Ogino S, Ose J, Perduca V, Phipps AI, Platz EA, Potter JD, Qu C, Rennert G, Sakoda LC, Schafmayer C, Schoen RE, Slattery ML, Tangen CM, Ulrich CM, van Duijnhoven FJ, Van Guelpen B, Visvanathan K, Vodicka P, Vodickova L, Vymetalkova V, Wang H, White E, Wolk A, Woods MO, Wu AH, Zheng W, Peters U, Gunter MJ. Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses. Gastroenterology. 2019 Dec 26. pii:S0016-5085(19)41951-3. doi:0.1053/j.gastro.2019.12.020. [Epub ahead of print] PubMed PMID: 31884074.

Catalano C, da Silva Filho MI, Frank C, Lu S, Jiraskova K, Vymetalkova V, Levy M, Liska V, Vycital O, Naccarati A, Vodickova L, Hemminki K, Vodicka P, Weber ANR, Försti A. Epistatic effect of TLR3 and cGAS-STING-IKKε-TBK1-IFN signaling variants on colorectal cancer risk. Cancer Med. 2019 Dec 23. doi:10.1002/cam4.2804. [Epub ahead of print] PubMed PMID: 31869529.

Archambault AN, Su YR, Jeon J, Thomas M, Lin Y, Conti DV, Win AK, Sakoda LC, Lansdorp-Vogelaar I, Peterse EF, Zauber AG, Duggan D, Holowatyj AN, Huyghe JR, Brenner H, Cotterchio M, Bézieau S, Schmit SL, Edlund CK, Southey MC, MacInnis RJ, Campbell PT, Chang-Claude J, Slattery ML, Chan AT, Joshi AD, Song M, Cao Y, Woods MO, White E, Weinstein SJ, Ulrich CM, Hoffmeister M, Bien SA, Harrison TA, Hampe J, Li CI, Schafmayer C, Offit K, Pharoah PD, Moreno V, Lindblom A, Wolk A, Wu AH, Li L, Gunter MJ, Gsur A, Keku TO, Pearlman R, Bishop DT, Castellví-Bel S, Moreira L, Vodicka P, Kampman E, Giles GG, Albanes D, Baron JA, Berndt SI, Brezina S, Buch S, Buchanan DD, Trichopoulou A, Severi G, Chirlaque MD, Sánchez MJ, Palli D, Kühn T, Murphy N, Cross AJ, Burnett-Hartman AN, Chanock SJ, Chapelle A, Easton DF, Elliott F, English DR, Feskens EJ, FitzGerald LM, Goodman PJ, Hopper JL, Hudson TJ, Hunter DJ, Jacobs EJ, Joshu CE, Küry S, Markowitz SD, Milne RL, Platz EA, Rennert G, Rennert HS, Schumacher FR, Sandler RS, Seminara D, Tangen CM, Thibodeau SN, Toland AE, van Duijnhoven FJ, Visvanathan K, Vodickova L, Potter JD, Männistö S, Weigl K, Figueiredo J, Martín V, Larsson SC, Parfrey PS, Huang WY, Lenz HJ, Castelao JE, Gago-Dominguez M, Muñoz-Garzón V, Mancao C, Haiman CA, Wilkens LR, Siegel E, Barry E, Younghusband B, Van Guelpen B, Harlid S, Zeleniuch-Jacquotte A, Liang PS, Du M, Casey G, Lindor NM, Le Marchand L, Gallinger SJ, Jenkins MA, Newcomb PA, Gruber SB, Schoen RE, Hampel H, Corley DA, Hsu L, Peters U, Hayes RB. Cumulative Burden of Colorectal Cancer-Associated Genetic Variants is More Strongly Associated With Early-onset vs Late-onset Cancer. Gastroenterology. 2019 Dec 19. pii: S0016-5085(19)41937-9. doi:10.1053/j.gastro.2019.12.012. [Epub ahead of print] PubMed PMID: 31866242.

Lu Y, Kweon SS, Cai Q, Tanikawa C, Shu XO, Jia WH, Xiang YB, Huyghe JR, Harrison TA, Kim J, Shin A, Kim DH, Matsuo K, Jee SH, Guo X, Wen W, Shi J, Li B, Wang N, Shin MH, Li HL, Ren ZF, Hwan Oh J, Oze I, Ahn YO, Jung KJ, Gao J, Gao YT, Pan ZZ, Kamatani Y, Chan AT, Gsur A, Hampe J, Le Marchand L, Li L, Lindblom A, Moreno V, Newcomb PA, Offit K, Pharoah PDP, van Duijnhoven FJB, Van Guelpen B, Vodicka PE, Weinstein SJ, Wolk A, Wu AH, Hsu L, Zeng YX, Long J, Peters U, Matsuda K, Zheng W. Identification of novel loci and new risk variant in known loci for colorectal cancer risk in East Asians. Cancer Epidemiol Biomarkers Prev. 2019 Dec 11. pii: cebp.0755.2019. doi: 10.1158/1055-9965.EPI-19-0755. [Epub ahead of print] PubMed PMID: 31826910.

Francavilla A, Turoczi S, Tarallo S, Vodicka P, Pardini B, Naccarati A. Exosomal microRNAs and other non-coding RNAs as colorectal cancer biomarkers: a review. Mutagenesis. 2019 Nov 30. pii: gez038. doi: 10.1093/mutage/gez038. [Epub ahead of print] PubMed PMID: 31784760.

Vodenkova S, Buchler T, Cervena K, Veskrnova V, Vodicka P, Vymetalkova V. 5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future. Pharmacol Ther. 2019 Nov 19:107447. doi:10.1016/j.pharmthera.2019.107447. [Epub ahead of print] Review. PubMed PMID:

Chattopadhyay S, Thomsen H, Weinhold N, Meziane I, Huhn S, da Silva Filho MI, Vodicka P, Vodickova L, Hoffmann P, Nöthen MM, Jöckel KH, Schmidt B, Landi S, Hajek R, Hallmans G, Pettersson-Kymmer U, Ohlsson C, Milani P, Merlini G, Rowcieno D, Hawkins P, Hegenbart U, Palladini G, Wechalekar A, Schönland SO, Houlston R, Goldschmidt H, Hemminki K, Försti A. Eight novel loci implicate shared genetic etiology in multiple myeloma, AL amyloidosis, and monoclonal gammopathy of unknown significance. Leukemia. 2019 Nov 6. doi:10.1038/s41375-019-0619-1. [Epub ahead of print] PubMed PMID: 31695157.

Vodicka P, Vodenkova S , Buchler T, Vodickova L. DNA repair capacity and response to treatment of colon cancer. Pharmacogenomics. 2019 Nov 6. doi:10.2217/pgs-2019-0070. [Epub ahead of print] PubMed PMID: 31691643.

Burocziova M, Burdova K, Martinikova AS, Kasparek P, Kleiblova P, Danielsen SA, Borecka M, Jenikova G, Janečková L, Pavel J, Zemankova P, Schneiderova M, Schwarzova L, Ticha I, Sun XF, Jiraskova K, Liska V, Vodickova L, Vodicka P, Sedlacek R, Kleibl Z, Lothe RA, Korinek V, Macurek L. Truncated PPM1D impairs
stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon. Cell Death Dis. 2019 Oct 28;10(11):818. doi:10.1038/s41419-019-2057-4. PubMed PMID: 31659152; PubMed Central PMCID:PMC6817818.

Niazi Y, Thomsen H, Smolkova B, Vodickova L, Vodenkova S, Kroupa M, Vymetalkova V, Kazimirova A, Barancokova M, Volkovova K, Staruchova M, Hoffmann P, Nöthen MM, Dusinska M, Musak L, Vodicka P, Hemminki K, Försti A. Distinct pathways associated with chromosomal aberration frequency in a cohort exposed to genotoxic compounds compared to general population. Mutagenesis. 2019 Oct 4. pii:gez024. doi: 10.1093/mutage/gez024. [Epub ahead of print] PubMed PMID: 31586183.

Opattova A, Horak J, Vodenkova S , Kostovcikova K, Cumova A, Macinga P, Galanova N, Rejhova A, Vodickova L, Kozics K, Turnovcova K, Hucl T, Sliva D, Vodicka P. Ganoderma Lucidum induces oxidative DNA damage and enhances the effect of 5-Fluorouracil in colorectal cancer in vitro and in vivo. Mutat Res. 2019 Sep;845:403065. doi: 10.1016/j.mrgentox.2019.06.001. Epub 2019 Jun 3. PubMed PMID: 31561886.

Vodicka P, Vodenkova S, Opattova A, Vodickova L. DNA damage and repair measured by comet assay in cancer patients. Mutat Res. 2019 Jul;843:95-110. doi: 10.1016/j.mrgentox.2019.05.009. Epub 2019 May 20. PubMed PMID: 31421745.

Kunzmann AT, Proença MA, Jordao HW, Jiraskova K, Schneiderova M, Levy M, Liska V, Buchler T, Vodickova L, Vymetalkova V, Silva AE, Vodicka P, Hughes DJ. Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients. Eur J Clin Microbiol Infect Dis. 2019 Jul 31. doi:10.1007/s10096-019-03649-1. [Epub ahead of print] PubMed PMID: 31367996.

Cervena K, Vodicka P, Vymetalkova V . Diagnostic and prognostic impact of cell-free DNA in human cancers: Systematic review. Mutation Research/Reviews in Mutation Research. July–September 2019. 781. 100-129.

Kroupa M , Rachakonda SK, Liska V, Srinivas N, Urbanova M, Jiraskova K, Schneiderova M, Vycital O, Vymetalkova V, Vodickova L, Kumar R, Vodicka P. Relationship of telomere length in colorectal cancer patients with cancer phenotype and patient prognosis. Br J Cancer. 2019 Jul 17. doi:10.1038/s41416-019-0525-3. [Epub ahead of print] PubMed PMID: 31312029.

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Elsnerová, K., Mohelniková-Duchonová, B., Čeřovská, E., Ehrlichová, M., Gut, I., Rob, L., Skapa, P., Hruda, M., Bartaková, A., Bouda, J., Vodička, P., Souček, P., Václavíková, R.,: (2016) Gene expression of membrane transporters: Importance for prognosis and progression of ovarian carcinoma. Oncol. Rep., 35(4): 2159-2170.

Försti, A., Frank, C., Smolková, B., Kazimirová, A., Barancoková, M., Vymetálková, V., Kroupa, M., Naccarati, A., Vodičková, L., Buchancová, J., Dusinská, M., Musak, L., Vodička, P., Hemminki, K.: (2016) Genetic variation in the major mitotic checkpoint genes associated with chromosomal aberrations in healthy humans. Cancer Lett., 380(2):442-446.

Kořenková, V., Slyšková, J., Novosadová, V., Pizzamiglio, S., Langerová, L., Bjorkman, J., Vyčítal, O., Liska, V., Levy, M., Veskrna, K., Vodička, P., Vodičková, L., Kubista, M., Verderio, P.: (2016)The focus on sample quality: Influence of colon tissue collection on reliability of qPCR data. Sci Rep, 6: 29023.

Kunická, T., Procházka, P., Krus, I., Bendová, P., Protivová, M., Susová, S., Hlaváč, V., Liska, V., Novák, P., Schneiderová, M., Pitule, P., Bruha, J., Vyčítal, O., Vodička, P., Souček, P.: (2016) Molecular profile of 5-fluorouracil pathway genes in colorectal carcinoma. BMC Cancer, 16(1):795.

Naccarati, A. , Rosa, F., Vymetálková V., Barone, E., Jirásková, K., Di Gaetano, C., Novotný, J., Levy, M., Vodičková, L., Gemignani, F., Buchler, T., Landi, S., Vodička, P., Pardini, B.: (2016) Double-strand break repair and colorectal cancer: gene variants within 3' UTRs and microRNAs binding as modulators of cancer risk and clinical outcome. Oncotarget, 7(17): 23156-23169.

Vodička, P. , Musak, L., Fiorito, G., Vymetálková, V., Vodičková, L., Naccarati, A.: (2016) DNA and chromosomal damage in medical workers exposed to anaesthetic gases assessed by the lymphocyte cytokinesis-block micronucleus (CBMN) assay. A critical review. Mutat. Res.-Rev. Mutat. Res., 770(Pt A): 26-34.

Vodička, P., Pardini, B., Vymetálková, V., Naccarati, A.: (2016) Polymorphisms in Non-coding RNA Genes and Their Targets Sites as Risk Factors of Sporadic Colorectal Cancer. Adv.Exp.Med.Biol., 937: 123-149.

Vymetálková, V. , Pardini, B., Rosa, F., Jirásková, K., Di Gaetano, C., Bendová, P., Levy, M., Veskrnová, V., Buchler, T., Vodičková, L., Naccarati,A., Vodička, P.: (2016) Polymorphisms in microRNA binding sites of mucin genes as predictors of clinical outcome in colorectal cancer patients. Carcinogenesis, IN PRESS.

Vymetálková, V., Vodička, P. , Pardini, B., Rosa, F., Levy, M., Schneiderová, M., Liska, V., Vodičková, L., Nilsson, T.K., Farkas, S.A.: (2016) Epigenome-wide analysis of DNA methylation reveals a rectal cancer-specific epigenomic signature. Epigenomics, 8(9): 1193-1207.

Zhang, M., Wang, Z., Obazee, O., Jia, J., Childs, E.J., Hoskins, J., Figlioli, G., Mocci, E., Collins, I., Chung, C.C., Hautman, C., Arslan, A.A., Beane-Freeman, L., Bracci, P.M., Buring, J., Duell, E.J., Gallinger, S., Giles, G.G., Goodman, G.E., Goodman, P.J., Kamineni, A., Kolonel, L.N., Kulke, M.H., Malats, N., Olson SH, Sesso HD, Visvanathan K, White E, Zheng W, Abnet CC, Albanes D, Andreotti, G., Brais, L., Bueno-de-Mesquita, H.B., Basso, D., Berndt, S.I., Boutron-Ruault, M.C., Bijlsma, M.F., Brenner, H., Burdette, L., Campa, D., Caporaso, N.E., Capurso, G., Cavestro, G.M., Cotterchio, M., Costello, E., Elena, J., Boggi, U., Gaziano, J.M., Gazouli, M., Giovannucci, E.L., Goggins, M., Gross, M., Haiman, C.A., Hassan, M., Helzlsouer, K.J., Hu, N., Hunter, D.J., Iskierka-Jazdzewska, E., Jenab, M., Kaaks, R., Key, T.J., Khaw, K.T., Klein, E.A., Kogevinas, M., Krogh, V., Kupcinskas, J., Kurtz, R.C., Landi, M.T., Landi, S., Le Marchand, L., Mambrini, A., Mannisto, S., Milne, R.L., Neale, R.E., Oberg, A.L., Panico, S., Patel, A.V., Peeters, P.H., Peters, U., Pezzilli, R., Porta, M., Purdue, M., Quiros, J.R., Riboli, E., Rothman, N., Scarpa, A., Scelo, G., Shu, X.O., Silverman, D.T., Souček, P., Strobel, O., Sund, M., Małecka-Panas, E., Taylor, P.R., Tavano, F., Travis, R.C., Thornquist, M., Tjønneland, A., Tobias, G.S., Trichopoulos, D., Vashist, Y., Vodička, P., Wactawski-Wende, J., Wentzensen, N., Yu, H., Yu, K., Zeleniuch-Jacquotte, A., Kooperberg, C., Risch, H.A., Jacobs, E.J., Li, D., Fuchs, C., Hoover, R., Hartge, P., Chanock, S.J., Petersen, G.M., Stolzenberg-Solomon, R.S., Wolpin, B.M., Kraft, P., Klein, A.P., Canzian, F., Amundadottir, L.T.: (2016) Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21. Oncotarget, IN PRESS


Aherne, S.T., Madden, S.F., Hughes, D.J., Pardini, B., Naccarati, A., Levy, M., Vodička, P., Neary, P., Dowling, P., Clynes, M.: (2015) Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression. BMC Cancer. 15: 329.

Campa, D., Rizzato, C., Stolzenberg-Solomon, R., Pacetti, P., Vodička, P., Cleary, S.P., Capurso, G., Bueno-de-Mesquita, H.B., Werner, J., Gazouli, M., Butterbach, K., Ivanauskas, A., Giese, N., Petersen, G.M., Fogar, P., Wang, Z., Bassi, C., Ryska, M., Theodoropoulos, G.E., Kooperberg, C., Li, D., Greenhalf, W., Pasquali, C., Hackert, T., Fuchs, C.S., Mohelnikova-Duchonova, B., Sperti, C., Funel, N., Dieffenbach, A.K., Wareham, N.J., Buring, J., Holcátová, I., Costello, E., Zambon, C.F., Kupcinskas, J., Risch, H.A., Kraft, P., Bracci, P.M., Pezzilli, R., Olson, S.H., Sesso, H.D., Hartge, P., Strobel, O., Małecka-Panas, E., Visvanathan, K., Arslan, A.A., Pedrazzoli, S., Souček, P., Gioffreda, D., Key, T.J., Talar-Wojnarowská, R., Scarpa, A., Mambrini, A., Jacobs, E.J., Jamroziak, K., Klein, A., Tavano, F., Bambi, F., Landi, S., Austin, M.A., Vodičková, L., Brenner, H., Chanock, S.J., Delle Fave, G., Piepoli, A., Cantore, M., Zheng, W., Wolpin, B.M., Amundadottir, L.T., Canzian, F.: (2015) TERT gene harbors multiple variants associated with pancreatic cancer susceptibility. Int J Cancer. 1;137(9):2175-2183.

Childs, E.J., Mocci, E., Campa, D., Bracci, P.M., Gallinger, S., Goggins, M., Li, D., Neale, R.E., Olson, S.H., Scelo, G., Amundadottir, L.T., Bamlet, W.R., Bijlsma, M.F., Blackford, A., Borges, M., Brennan, P., Brenner, H., Bueno-de-Mesquita, H.B., Canzian, F., Capurso, G., Cavestro, G.M., Chaffee, K.G., Chanock, S.J., Cleary, S.P., Cotterchio, M., Foretová, L., Fuchs, C., Funel, N., Gazouli, M., Hassan, M., Herman, J.M., Holcatová, I., Holly, E.A., Hoover, R.N., Hung, R.J., Janout, V., Key, T.J., Kupcinskas, J., Kurtz, R.C., Landi, S., Lu, L., Malecka-Panas, E., Mambrini, A., Mohelniková-Duchonová, B., Neoptolemos, J.P., Oberg, A.L., Orlow, I., Pasquali, C., Pezzilli, R., Rizzato, C., Saldia, A., Scarpa, A., Stolzenberg-Solomon, R.Z., Strobel, O., Tavano, F., Vashist, Y.K., Vodička, P., Wolpin, B.M., Yu, H., Petersen, G.M., Risch, H.A., Klein, A.P.: (2015) Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer. Nat Genet. 47(8):911-916.

Dowling, P., Hughes, D. J., Larkin, A. M., Meiller, J., Henry, M., Meleady, P., Lynch, V., Pardini, B., Naccarati, A., Levy, M., Vodička, P., Neary, P., Clynes, M.: (2015) Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer. Clin. Chim. Acta. 441: 133-141.

Hemminki, K., Frank, C., Försti, A., Musak, L., Kazimirova, A., Barancokova, M., Horska, A., Vymetalková, V., Šmerhovský, Z.,Naccarati, A., Souček, P., Vodičková, L., Buchancová, J., Smolková, B., Dušinská, M., Vodička, P.: (2015) Metabolic gene variants associated with chromosomal aberrations in healthy humans. Gene Chromosomes Cancer. 54(4): 260-266.

Hemminki, K., Rachakonda, S., Musak, L., Vymetálková, V., Halasová, E., Försti, A., Vodičková, L., Buchancová, J., Vodička, P., Kumar, R.: (2015) Telomere length in circulating lymphocytes: Association with chromosomal aberrations. Gene Chromosomes Cancer. 54(3): 194-196.

Pardini, B., Rosa, F., Naccarati, A., Vymetálková, V., Ye, Y., Wu, X., di Gaetano, C., Buchler, T., Novotný, J., Matullo, G., Vodička, P.: (2015) Polymorphisms in microRNA genes as predictors of clinical outcomes in colorectal cancer patients. Carcinogenesis. 31(6): 82-86.

Slyšková, J., Cordero, F., Pardini, B., Korenková, V., Vymetalková, V., Bielik, L., Vodičková, L., Pitule, P., Liska, V., Matejka, V. M., Levy, M., Buchler, T., Kubista, M., Naccarati, A., Vodička, P.: (2015) Post-treatment recovery of suboptimal DNA repair capacity and gene expression levels in colorectal cancer patients. Mol. Carcinog., 54 (9): 769-778.

Vodenková, S., Polivková, Z., Musak, L., Šmerhovský, Z., Zoubková, H., Sytarová, S., Kavcová, E., Halasová, E., Vodičková, L., Jirásková, K., Svoboda, M., Ambrus, M., Hemminki, K., Vodička, P.: (2015) Structural chromosomal aberrations as potential risk markers in incident cancer patients. Mutagenesis.30(4):557-563.

Vodička, P., Caja, F., Vymetálková, V., Procházka, P., Vodičková, L., Schwarzová, L., Slyšková, J., Kumar, R., Schneiderová, M.: (2015) Ile68Met germline variant in exon 2 of the mutL homolog 1 gene in a colorectal cancer patient. Oncol. Lett. 9(1): 183-186.

Vodička, P., Musak, L., Frank, C., Kazimirova, A., Vymetálková, V., Barancoková, M., Smolková, B., Dzupinková, Z., Jirasková, K., Vodenková, S., Kroupa, M., Osina, O., Naccarati, A., Palitti, F., Försti, A., Dusinská, M., Vodičková, L., Hemminki, K.: (2015) Interactions of DNA repair gene variants modulate chromosomal aberrations in healthy subjects. Carcinogenesis.36(11): 1299-1306.

Vymetálková, V., Souček, P., Kunicka, T., Jirásková, K., Brynychova, V., Pardini, B., Novosadova, V., Polivkova, Z., Kubackova, K., Kozevnikovova, R., Ambrus, M., Vodičková, L., Naccarati, A., Vodička, P.: (2015) Genotype and Haplotype Analyses of TP53 Gene in Breast Cancer Patients: Association with Risk and Clinical Outcomes. PLoS One. 10(7): e0134463.


Farkas, S. A., Vymetálková, V., Vodičková, L., Vodička, P., Nilsson, T. K.: (2014) DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/β-catenin signaling pathway genes. Epigenomics 6(2): 179-191.

Huhn, S., Bevier, M., Pardini, B., Naccarati, A., Vodičková, L., Novotny, J., Vodička, P., Hemminki, K., Försti, A.: (2014) Colorectal cancer risk and patients' survival: influence of polymorphisms in genes somatically mutated in colorectal tumors. Cancer Causes Control. 25(6): 759-769.

Kunická, T., Václavíková, R., Hlaváč, V., Vrána, D., Pecha, V., Rauš, K., Trnková, M., Kubáčková, K., Ambruš, M., Vodičková, L., Vodička, P., Souček, P.: (2014) Non-Coding Polymorphisms in Nucleotide Binding Domain 1 in ABCC1 Gene Associate with Transcript Level and Survival of Patients with Breast Cancer. PLoS One 9(7): e101740.

Lu, S., Pardini, B., Cheng, B., Naccarati, A., Huhn, S., Vymetálková, V., Vodičková, L., Buchler, T., Hemminki, K., Vodička, P., Försti, A.: (2014) Single Nucleotide Polymorphisms within Interferon Signaling Pathway Genes Are Associated with Colorectal Cancer Susceptibility and Survival. PLoS One 9(10): e111061.

Makovický, P., Tumova, E., Volek, Z., Makovický, P., Vodičková, L., Slyšková, J., Svoboda, M., Rejhová, A., Vodička, P., Samasca, G., Králová, A., Nagy, M., Mydlarova-Blascaková, M., Poracova, J.: (2014) Histopathological aspects of liver under variable food restriction: Has the intense one-week food restriction a protective effect on non-alcoholic-fatty-liver-disease (NAFLD) development?Pathol. Res. Pract. 210(12): 855-862.

Makovický, P., Tůmová, E., Volek, Z., Makovický, P., Vodička, P.: (2014) Histological aspects of the small intestine under variable feed restriction: The effects of short and intense restriction on a growing rabbit model. Exp. Ther. Med. 8(5): 1623-1627.

Pardini, B., Verderio, P., Pizzamiglio, S., Nici, C., Maiorana, M. V., Naccarati, A., Vodičková, L., Vymetálková, V., Veneroni, S., Daidone, M. G., Ravagnani, F., Bianchi, T., Bujenda, L., Carracedo, A., Castells, A., Ruiz-Ponte, C., Morreau, H., Howarth, K., Jones, A., Castellvı´-Bel, S., Li L., Tomlinson, I., Van Wezel, T., Vodička, P., Radice, P., Peterlongo, P., the EPICOLON Consortium: (2014) Association between CASP8 –652 6N Del Polymorphism (rs3834129) and Colorectal Cancer Risk: Results from a Multi-Centric Study. PLoS ONE 9(3): e91310.

Pardini, B., Bermejo, J. L., Naccarati, A., Di Gaetano, C., Rosa, F., Legrand, C., Novotny, J., Vodička, P., Kumar, R.: (2014) Inherited variability in a master regulator polymorphism (rs4846126) associates with survival in 5-FU treated colorectal cancer patients.Mutat. Res.-Fundam. Mol. Mech. Mutagen. 766-767: 7-13.

Svoboda, M., Slyšková, J., Schneiderova, M., Makovicky, P., Bielik, L., Levy, M., Lipska, L., Hemmelova, B., Kala, Z., Protivankova, M., Vycital, O., Liska, V., Schwarzova, L., Vodičková, L, Vodička P.: (2014) HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients. Carcinogenesis. 35(7): 1510-1515.

Slyšková, J., Lorenzo, Y., Karlsen, A., Carlsen, M. H., Novosadová, V., Blomhoff, R., Vodička, P., Collins, A. R.: (2014) Both genetic and dietary factors underlie individual differences in DNA damage levels and DNA repair capacity. DNA Repair (Amst). 16 :66-73.

Slyšková, J., Langie, S, A. , Collins, A. R., Vodička, P.: (2014) Functional evaluation of DNA repair in human biopsies and their relation to other cellular biomarkers. Front Genet. 5: 116.

Švec, J., Schwarzová, L., Janošíková, B., Štekrová, J., Mandys, V., Kment, M., Vodička, P.: (2014) Synchronous gastric and sebaceous cancers, a rare manifestation of MLH1-related Muir-Torre syndrome. Int. J. Clin. Exp. Pathol. 7(8): 5196-5202.

Vymetálková, V., Pardini, B., Rosa, F., Di Gaetano, C., Novotny, J., Levy, M., Buchler, T., Slyšková, J., Vodičková, L., Naccarati, A., Vodička, P.: (2014) Variations in mismatch repair genes and colorectal cancer risk and clinical outcome. Mutagenesis. 29(4): 259-265.

Vymetálková, V., Slyšková, J., Korenková, V., Bielik, L., Langerová, L., Procházka, P., Rejhová, A., Schwarzová, L., Pardini, B.,Naccarati, A., Vodička, P.: (2014) Molecular characteristics of mismatch repair genes in sporadic colorectal tumors in Czech patients BMC Med. Genet. 15(1) :17.

Wolpin, B. M., Rizzato, C., Kraft, P., Kooperberg, C., Petersen, G. M., Wang, Z., Arslan, A. A., Beane-Freeman, L., Bracci, P.M., Buring, J., Canzian, F., Duell, E. J., Gallinger, S., Giles, G. G., Goodman, G. E., Goodman, P. J., Jacobs, E. J., Kamineni, A., Klein, A. P., Kolonel, L. N., Kulke, M. H., Li, D., Malats, N., Olson, S. H., Risch, H. A., Sesso, H. D., Visvanathan, K., White, E., Zheng, W., Abnet, C. C., Albanes, D., Andreotti, G., Austin, M. A., Barfield, R., Basso, D., Berndt, S. I., Boutron-Ruault, M. C., Brotzman, M., Büchler, M. W., Bueno-de-Mesquita, H. B., Bugert, P., Burdette, L., Campa, D., Caporaso, N. E., Capurso, G., Chung, C., Cotterchio, M., Costello, E., Elena, J., Funel, N., Gaziano, J. M., Giese, N. A., Giovannucci, E. L., Goggins, M., Gorman, M. J., Gross, M., Haiman, C. A., Hassan, M., Helzlsouer, K. J., Henderson, B. E., Holly, E. A., Hu, N., Hunter, D. J., Innocenti, F., Jenab, M., Kaaks, R., Key, T. J., Khaw, K. T., Klein, E. A., Kogevinas, M., Krogh, V., Kupcinskas, J., Kurtz, R. C., LaCroix, A., Landi, M. T., Landi, S., Le Marchand, L., Mambrini, A., Mannisto, S., Milne, R. L., Nakamura, Y., Oberg, A. L., Owzar, K., Patel, A. V., Peeters, P. H., Peters, U., Pezzilli, R., Piepoli, A., Porta, M., Real, F. X., Riboli, E., Rothman, N., Scarpa, A., Shu, X. O., Silverman, D. T., Soucek, P., Sund, M., Talar-Wojnarowska, R., Taylor, P. R., Theodoropoulos, G. E., Thornquist, M., Tjønneland, A., Tobias, G. S., Trichopoulos, D., Vodička, P., Wactawski-Wende, J., Wentzensen, N., Wu, C., Yu, H., Yu, K., Zeleniuch-Jacquotte, A., Hoover, R., Hartge, P., Fuchs, C., Chanock, S. J., Stolzenberg-Solomon, R. S., Amundadottir, L. T.: (2014) Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Nature Genet. 46(9): 994-1000.


Azqueta, A., Langie, S. A., Slyšková, J., Collins, A. R.: (2013) Measurement of DNA base and nucleotide excision repair activities in mammalian cells and tissues using the comet assay - A methodological overview. DNA Repair (Amst) 12: 1007-1010.

Campa, D., Rizzato, C., Capurso, G., Giese, N., Funel, N., Greenhalf, W., Souček, P., Gazouli, M., Pezzilli, R, Pasquali, C., Talar-Wojnarowska, R., Cantore, M., Andriulli, A., Scarpa, A., Jamroziak, K., Delle Fave, G., Costello, E., Khaw, K. T., Heller, A., Key, T. J., Theodoropoulos, G., Malecka-Panas, E., Mambrini, A., Bambi, F., Land, S., Pedrazzoli, S., Bassi, C., Pacetti, P., Piepoli, A., Tavano, F., di Sebastiano, P., Vodičková, L., Basso, D., Plebani, M., Fogar, P., Büchler, M. W., Bugert, P., Vodička, P., Boggi, U., Neoptolemos, J. P., Werner, J., Canzian, F.: (2013) Genetic susceptibility to pancreatic cancer and its functional characterisation: The PANcreatic Disease ReseArch (PANDoRA) consortium. Dig. Liver Dis. 45(2): 95-99.

Campa, D., Rizzato, C., Bauer, A. S., Werner, J., Capurso, G., Costello, E., Talar-Wojnarowska, R., Jamroziak, K., Pezzilli, R., Gazouli, M., Khaw, K. T., Key, T. J., Bambi, F., Mohelnikova-Duchonova, B., Heller, A., Landi, S., Vodičková, L., Theodoropoulos, G., Bugert, P.,Vodička, P., Hoheisel, J., Delle Fave, G., Neoptolemos, J., Souček, P., Buchler, M. W., Giese, N. A., Canzian F.: (2013) Lack of replication of seven pancreatic cancer susceptibility lociidentified in two Asian populations. Cancer Epidemiol. Biomarkers Prev.22(2): 320-323.

Lu, S., Bevier, M., Huhn, S., Sainz, J., Lascorz, J., Pardini, B., Naccarati, A., Vodičková, L., Novotný, J., Hemminki, K., Vodička, P., Försti A.: (2013) Genetic variants in C-type lectin genes are associated with colorectal cancer susceptibility and clinical outcome.Int. J. Cancer. 133(10): 2325-2333.

Makovicky, P., Rimarova, K., Boor, A., Makovicky, P., Vodička, P., Samasca, G., Kruzliak, P.: (2013) Correlation between antibodies and histology in celiac disease: Incidence of celiac disease is higher than expected in the pediatric population. Mol. Med. Rep.8(4): 1079-1083.

Mušák, L., Šmerhovský, Z., Halasová, E., Osina, O., Letková, L., Vodičková, L., Poláková, V., Buchancová, J., Hemminki, K.,Vodička, P.: (2013) Chromosomal damage among medical staff occupationally exposed to volatile anesthetics, antineoplastic drugs, and formaldehyde. Scand. J. Work Environ. Health. 39(6): 618-630.

Pardini, B., Rosa, F., Barone, E., Di Gaetano, C., Slyšková, J., Novotný, J., Levy, M., Garritano, S., Vodičková, L., Buchler, T., Gemignani, F., Landi, S., Vodička, P., Naccarati, A.: (2013) Variation within 3' UTRs of base excision repair genes and response to therapy in colorectal cancer patients: a potential modulation of microRNAs binding. Clin. Cancer Res. 19(21): 6044-6056.

Picelli, S., Bermejo, J. L., Change-Claude, J., Hoffmeister, M., Fernández-Rozadilla, C., Carracedo, A., Castells, A., Castellví-Bel, S.,Naccarati, A., Pardini, B., Vodičková, L., Hüller, H., Talseth-Palmer, B. A., Stibbard, G., Peterlongo, P., Nici, C., Veneroni, S., Li, L., Casey, G., Tenesa, A., Farrington, S. M., Tomlinson, I., Moreno, V., van Wezel, T., Wijnen, J., Dunlop, M., Radice, P., Scott, R. J.,Vodička, P., Ruiz-Ponte, C., Brenner, H., Buch, S., Völzke, H., Hampe, J., Schafmayer, C., Lindblom, A.: Meta-Analysis of Mismatch Repair Polymorphisms within the Cogent Consortium for Colorectal Cancer Susceptibility; PLoS One 8(9): e72091.

Poláková-Vymetálková, V., Vannucci, L., Korenková, V., Procházka, P., Slyšková, J., Vodičková, L., Rusňáková, V., Bielik, L., Burocziová, M., Rossmann., P., Vodička, P.: (2013) Evaluation of tumor suppressor gene expressions and aberrant methylation in the colon of cancer-induced rats: a pilot study. Mol. Biol. Rep. 40(10): 5921-5929.

Procházka, P., Hrabeta, J., Vicha, A., Cipro, S., Stejskalová, E., Musil, Z., Vodička, P., Eckschlager, T.: (2013) Changes in MYCN expression in human neuroblastoma cell lines following cisplatin treatment may not be related to MYCN copy numbers. Oncol. Rep. 29(6):2415-2421.

Rizzato, C., Campa, D., Pezzilli, R., Souček, P., Greenhalf, W., Capurso, G., Talar-Wojnarowska, R., Heller, A., Jamroziak, K., Khaw, K. T., Key, T. J., Bambi, F., Landi, S., Mohelniková-Duchoňová, B., Vodičková, L., Büchler, M. W., Bugert. P., Vodička, P., Neoptolemos, J. P., Werner, J., Hoheisel, J. D., Bauer, A. S., Giese, N., Canzian, F.: (2013) ABO blood groups and pancreatic cancer risk and survival: Results from the PANcreatic Disease ReseArch (PANDoRA) consortium. Oncol. Rep. 29(4): 1637-1644.

AZV 17-30920A Characterization of acquired chemoresistance by DNA repair gene profiling in colon cancer patients through non-invasive repeated analysis. PI: Ing. Vymetálková, (2017-2020).

GACR 18- 09709S  Mapping the traits involved in malignant transformation of colorectal adenoma into carcinoma. PI: Dr. Vodička, (2018-2020).

NV 18-03-00199 Identification of diagnostic markers in colorectal cancer by profiling of trascriptome, DNA methylome and microbiome in adenoma-carcinoma transition. PI: Dr. Vodička, (2018-2021).

GACR 19-10543S Changes in DNA repair system associated with therapy outcome of ovarian carcinoma. PI: Dr. Vodička, (2019-2021).

NV19-09-00237 The clinicopathological and molecular factors detected in metastases, predicting of treatment response in colon cancer patients. PI: Dr.Vymetálková, (2019-2022).

GACR 20-03997S Influence of microbial metabolites and diet on genome and epigenoma in colorectal carcinoma PI: Dr. Vodička, (2020-2022)

Thomayer hospital Prague

IKEM, Prague

General teaching hospital, Prague

Teaching hospital Pilsen, Pilsen

Teaching hospital Kralovske Vinohrady, Prague

Masaryk University, Brno

First Medical Faculty, Charles University, Prague

Third Medical Faculty, Charles University, Prague

Biomedical Centre, Faculty of Medicine, Pilsen, Charles University, Prague

National Institute of Public Health, Prague

Institute of Biotechnology, CAS v.v.i., Vestec

Institute of Molecular Genetics, ASCR, Prague

Institute of Microbiology, ASCR, Prague

CEITEC - central european institute of technology, Brno

DKFZ (German Cancer Research Center) Heidelberg, Germany (prof. Hemminki, prof. Kumar, Dr. Canzian, Dr. Főrsti)

University of Pisa, Italy (prof. Landi, prof. Barale, dr. Campa)

Italian Institute for Genomic Medicine, Torino, Italy (Dr. Naccarati, Dr. Pardini)

Leiden University Medical Center, Leiden, Holland (prof. Van Wezel)

IDIBAPS / CIBERehd / Hospital Clínic, Barcelona, Spain (Dr. Castellvi-Bel)

Umeå University, Sweden (Prof. Torbjőrn Nilsson)

Vienna Medical University, Austria (prof. Knasműller, Dr.Gsur)

RCSI Royal College of Surgeons in Ireland, Ireland (Dr. Hughes)

Genetics and Epidemiology of Colorectal cancer Consortium (GECCO)

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