Institute of Experimental Medicine CAS

In our Department we investigate molecular characteristics of solid cancers, especially of the colon, rectum, pancreas and ovaries. Within these studies we focus on the molecular epidemiological level in order 1. to identify biomarkers of increased predisposition to tumour diseases, 2. enable early diagnostics, 3. assess individual responses to anti-tumour treatment, 4. and determine long-term prognosis. The Department has been working with different types of biological material from a patients with cancer diseases, such as solid tissue, blood cells or plasma.

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Deputy Head:

Veronika Vymetálková, MSc, PhD.
E-mail: veronika.vymetalkova@iem.cas.cz
Phone: +420 241 062 699

Research Scientists:

Alena Opattová, PhD.
Pavel Vodička, MD, PhD. 
Ludmila Vodičková, MD, PhD.
Veronika Vymetálková, MSc, PhD.
Alessio Naccarati, MD, PhD.

PhD. Students:

Petra Bendová, MSc
Klára Červená, MSc
Andrea Čumová, MSc

Josef Horák, MD
Kateřina Jirásková, MSc
Jan Král, MD
Michal Kroupa, MSc
Peter Mačinga, MD
Alexandra Rejhová, MSc
Soňa Vodenková, MSc

Phone: +420 241 062 251

Undergraduate Students:

Alexandra Dolníková
Kristýna Tomášová

External Collaborators:

Jana Slyšková, Ph.D. 
Markéta Urbanová, Ph.D.

Important results in 2018

1. Analysis of the effect of functional genetic variants in DNA repair genes in relation to the risk of colorectal cancer

Results of the study of 16 genetic variants of DNA repair genes:

Identification of a single genetic polymorphism (rs3204953, the REV3L gene) associated with a 2.3-fold higher risk of disease for the carriers of variant genotype (p = 0.006) in association study.

Identification of variants rs3218649 in the gene POLQ and rs7689099 in the NEIL3 gene as significantly associated with overall survival (OS) and recurrent survival (RFS), using CART analysis.

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Publication : Jiraskova, K., Hughes, D., Brezina, S., Gumpenberger, T., Veskrnova, V., Buchler, T., … Vodicka, P. (2018). Functional Polymorphisms in DNA Repair Genes Are Associated with Sporadic Colorectal Cancer Susceptibility and Clinical Outcome. International Journal of Molecular Sciences, 20(1), 97. https://doi.org/10.3390/ijms20010097

 

2. Base excision repair capacity as a determinant of prognosis and therapy response in colon cancer patients

Our results indicate that BER-DRC in non-malignant adjacent mucosa was positively associated with overall survival (P = 0.007) and relapse-free survival (P = 0.04). Additionally, in multivariate analysis, good therapy responders in TNM stage II and III with an elevated BER-DRC in mucosa exhibited better overall survival. Moreover, the overall survival of these patients was even better in the presence of a decreased BER-DRC in tumor tissue. The ratio of BER-DRC in tumor tissue over BER-DRC in mucosa positively correlated with advanced tumor stage (P = 0.003). 

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Publication : Vodenkova, S., Jiraskova, K., Urbanova, M., Kroupa, M., Slyskova, J., Schneiderova, M., … Vodicka, P. (2018). Base excision repair capacity as a determinant of prognosis and therapy response in colon cancer patients. DNA Repair, 72, 77–85. https://doi.org/10.1016/j.dnarep.2018.09.006

 

3. Expression profile of miR-17/92 cluster is predictive of treatment response in rectal cancer

We identified RC-specific miRNA signature that distinguishes responders from non-responders to adjuvant chemotherapy. A predominant part of identified miRNAs was represented by the members of miR-17/92 cluster. Upregulation of miRNA-17, -18a, -18b, -19a, -19b, -20a, -20b and -106a in tumor was associated with higher risk of tumor relapse and their overexpression in RC cell lines stimulated cellular proliferation. Examination of these miRNAs in plasma exosomes showed that their levels differed between RC patients and healthy controls and correlated with patient's treatment response. 

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Publication : Kral, J., Korenkova, V., Novosadova, V., Langerova, L., Schneiderova, M., Liska, V., … Slyskova, J. (2018). Expression profile of miR-17/92 cluster is predictive of treatment response in rectal cancer. Carcinogenesis, 39(11), 1359–1367. https://doi.org/10.1093/carcin/bgy100

 

4. Discovery of common and rare genetic risk variants for colorectal cancer

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P< 5 × 10−8, bringing the number of known independent signals for CRC to ~100. New signals implicate lower-frequency variants, Krüppel-like factors, Hedgehog signaling, Hippo-YAP signaling, long noncoding RNAs and somatic drivers, and support a role for immune function. Heritability analyses suggest that CRC risk is highly polygenic, and larger, more comprehensive studies enabling rare variant analysis will improve understanding of biology underlying this risk and influence personalized screening strategies and drug development.

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Publication:  Huyghe, J. R., Bien, S. A., Harrison, T. A., Kang, H. M., Chen, S., Schmit, S. L., … Peters, U. (2019). Discovery of common and rare genetic risk variants for colorectal cancer. Nature Genetics, 51(1), 76–87. https://doi.org/10.1038/s41588-018-0286-6

 

 

Important results in 2017

1. MicroRNA-binding site polymorphisms in genes involved in colorectal cancer etiopathogenesis as a predictive biomarkers for treatment of the disease

The CC genotype in rs8679 in PARP gene was associated with an increased risk of recurrence/progression in pacient. Carriers of at least on C allele were at a decreased risk of cancer (P = 0.005). Moreover the CC genotype in rs8679 was also associated with an increased risk of recurrence/progression in patients that received 5-FU-based chemotherapy (log-rank test P = 0.03).

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Kaplan–Meier EFS curves in CRC patients undergoing 5-FU-based chemotherapy stratified for rs8679 in PARP1 gene.

Publication:  Michaela Schneiderova, Alessio Naccarati, Barbara Pardini, Fabio Rosa, Cornelia Di Gaetano, Katerina Jiraskova, Alena Opattova, Miroslav Levy, Karel Veskrna, Veronika Veskrnova, Tomas Buchler, Stefano Landi, Pavel Vodicka, Veronika Vymetalkova; MicroRNA-binding site polymorphisms in genes involved in colorectal cancer etiopathogenesis and their impact on disease prognosis, Mutagenesis, Volume 32, Issue 5, 17 October 2017, Pages 533-542, https://doi.org/10.1093/mutage/gex026

 

2. The relative telomere length in peripheral lymphocytes may reflect the susceptibility to radiomimetics in colorectal cancer patient

We observed statistically significant increased level of chromosomal damage in CRC patients compared with controls after bleomycin treatment. Patients with shorter relative telomere length exhibited significantly higher amount of damage in peripheral lymphocytes after bleomycin treatment

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Spearman correlation of relative telomere length and chromosomal damage in CRC patients and controls.

Publication: Kroupa M , Polivkova Z, Rachakonda S, et al. Bleomycin-induced chromosomal damage and shortening of telomeres in peripheral blood lymphocytes of incident cancer patients. Genes Chromosomes Cancer. 2018;57:61–69. https://doi.org/10.1002/gcc.22508

 

Important results in 2016

1. Polymorphisms in microRNA binding sites of mucin genes are significantly associated with the risk of colorectal cancer development and patient's survival

Patients carrying the CC genotype of rs886403 in MUC21 displayed a shorter survival and higher recurrence risk when compared with TT.

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Publication: Veronika Vymetalkova , Barbara Pardini, Fabio Rosa, Katerina Jiraskova, Cornelia Di Gaetano, Petra Bendova, Miloslav Levy, Veronika Veskrnova, Tomas Buchler, Ludmila Vodickova, Alessio Naccarati, Pavel Vodicka; Polymorphisms in microRNA binding sites of mucin genes as predictors of clinical outcome in colorectal cancer patients, Carcinogenesis, Volume 38, Issue 1, 1 January 2017, Pages 28–39, https://doi.org/10.1093/carcin/bgw114

 

2. DNA methylation profiles of selected genes as biomarkers in rectal carcinogenesis

Analysis of methylation profile of paired samples of patient with rectal carcinoma (tumor tussue vs. adjacent mucosa) revealed aberrant methylation in 33 genes. This study has demonstrated the possibility of using specific methylated DNA profiles as diagnostic biomarkers in patients with rectal carcinoma.

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Publication: Veronika Vymetalkova , Pavel Vodicka, Barbara Pardini, Fabio Rosa, Miroslav Levy, Michaela Schneiderova, Vaclav Liska, Ludmila Vodickova, Torbjörn K Nilsson, and Sanja A Farkas; Epigenome-wide analysis of DNA methylation reveals a rectal cancer-specific epigenomic signature, Epigenomics 2016 8:9, 1193-1207, https://doi.org/10.2217/epi-2016-0044

 

2019

Niazi Y, Thomsen H, Smolkova B, Vodickova L, Vodenkova S, Kroupa M, Vymetalkova V, Kazimirova A, Barancokova M, Volkovova K, Staruchova M, Hoffmann P, Nöthen MM, Dusinska M, Musak L, Vodicka P, Hemminki K, Försti A. Distinct pathways associated with chromosomal aberration frequency in a cohort exposed to genotoxic compounds compared to general population. Mutagenesis. 2019 Oct 4. pii:gez024. doi: 10.1093/mutage/gez024. [Epub ahead of print] PubMed PMID: 31586183.

Opattova A, Horak J, Vodenkova S , Kostovcikova K, Cumova A, Macinga P, Galanova N, Rejhova A, Vodickova L, Kozics K, Turnovcova K, Hucl T, Sliva D, Vodicka P. Ganoderma Lucidum induces oxidative DNA damage and enhances the effect of 5-Fluorouracil in colorectal cancer in vitro and in vivo. Mutat Res. 2019 Sep;845:403065. doi: 10.1016/j.mrgentox.2019.06.001. Epub 2019 Jun 3. PubMed PMID: 31561886.

Vodicka P, Vodenkova S, Opattova A, Vodickova L. DNA damage and repair measured by comet assay in cancer patients. Mutat Res. 2019 Jul;843:95-110. doi: 10.1016/j.mrgentox.2019.05.009. Epub 2019 May 20. PubMed PMID: 31421745.

Kunzmann AT, Proença MA, Jordao HW, Jiraskova K, Schneiderova M, Levy M, Liska V, Buchler T, Vodickova L, Vymetalkova V, Silva AE, Vodicka P, Hughes DJ. Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients. Eur J Clin Microbiol Infect Dis. 2019 Jul 31. doi:10.1007/s10096-019-03649-1. [Epub ahead of print] PubMed PMID: 31367996.

Cervena K, Vodicka P, Vymetalkova V . Diagnostic and prognostic impact of cell-free DNA in human cancers: Systematic review. Mutation Research/Reviews in Mutation Research. July–September 2019. 781. 100-129. doi.org/10.1016/j.mrrev.2019.05.002

Kroupa M , Rachakonda SK, Liska V, Srinivas N, Urbanova M, Jiraskova K, Schneiderova M, Vycital O, Vymetalkova V, Vodickova L, Kumar R, Vodicka P. Relationship of telomere length in colorectal cancer patients with cancer phenotype and patient prognosis. Br J Cancer. 2019 Jul 17. doi:10.1038/s41416-019-0525-3. [Epub ahead of print] PubMed PMID: 31312029.

Murphy N, Moreno V, Hughes DJ, Vodickova L, Vodicka P, Aglago EK, Gunter MJ, Jenab M. Lifestyle and dietary environmental factors in colorectal cancer susceptibility. Mol Aspects Med. 2019 Jun 21. pii: S0098-2997(19)30033-0. doi:10.1016/j.mam.2019.06.005. [Epub ahead of print] Review. PubMed PMID: 31233770.

Pardini B, Corrado A, Paolicchi E, Cugliari G, Berndt SI, Bezieau S, Bien SA, Brenner H, Caan BJ, Campbell PT, Casey G, Chan AT, Chang-Claude J, Cotterchio M, Gala M, Gallinger SJ, Haile RW, Harrison TA, Hayes RB, Hoffmeister M, Hopper JL, Hsu L, Huyghe J, Jenkins MA, Le Marchand L, Lin Y, Lindor NM, Nan H, Newcomb PA, Ogino S, Potter JD, Schoen RE, Slattery ML, White E, Vodickova L, Vymetalkova V, Vodicka P, Gemignani F, Peters U, Naccarati A, Landi S. DNA repair and cancer in colon and rectum: novel players in genetic susceptibility. Int J Cancer. 2019 Jun17. doi: 10.1002/ijc.32516. [Epub ahead of print] PubMed PMID: 31209889.

Marcuello M, Vymetalkova V, Neves RPL, Duran-Sanchon S, Hm V, Tham E, van Dalum G, Flügen G, Garcia-Barberan V, Fijneman RJ, Castells A, Vodicka P, Lind GE, Stoecklein NH, Heitzer E, Gironella M. Circulating biomarkers for early detection and clinical management of colorectal cancer. Mol Aspects Med. 2019 Jun 9. pii: S0098-2997(19)30009-3. doi: 10.1016/j.mam.2019.06.002. [Epub ahead of print] Review. PubMed PMID: 31189073.

Lu S, Catalano C, Huhn S, Pardini B, Bartu L, Vymetalkova V, Vodickova L, Levy M, Buchler T, Hemminki K, Vodicka P, Försti A. Single nucleotide polymorphisms within MUC4 are associated with colorectal cancer survival. PLoS One. 2019 May 15;14(5):e0216666. doi: 10.1371/journal.pone.0216666. eCollection 2019. PubMed PMID: 31091244.

Wirbel J, Pyl PT, Kartal E, Zych K, Kashani A, Milanese A, Fleck JS, Voigt AY, Palleja A, Ponnudurai R, Sunagawa S, Coelho LP, Schrotz-King P, Vogtmann E, Habermann N, Niméus E, Thomas AM, Manghi P, Gandini S, Serrano D, Mizutani S, Shiroma H, Shiba S, Shibata T, Yachida S, Yamada T, Waldron L, Naccarati A,
Segata N, Sinha R, Ulrich CM, Brenner H, Arumugam M, Bork P, Zeller G. Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer. Nat Med. 2019 Apr;25(4):679-689. doi:10.1038/s41591-019-0406-6. Epub 2019 Apr 1. PubMed PMID: 30936547.

Thomas AM, Manghi P, Asnicar F, Pasolli E, Armanini F, Zolfo M, Beghini F, Manara S, Karcher N, Pozzi C, Gandini S, Serrano D, Tarallo S, Francavilla A, Gallo G, Trompetto M, Ferrero G, Mizutani S, Shiroma H, Shiba S, Shibata T, Yachida S, Yamada T, Wirbel J, Schrotz-King P, Ulrich CM, Brenner H, Arumugam M, Bork P, Zeller G, Cordero F, Dias-Neto E, Setubal JC, Tett A, Pardini B, Rescigno M, Waldron L, Naccarati A, Segata N. Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation. Nat Med. 2019 Apr;25(4):667-678. doi:10.1038/s41591-019-0405-7. Epub 2019 Apr 1. PubMed PMID: 30936548.

Vymetalkova V, Vodicka P, Vodenkova S , Alonso S, Kunz M, Schneider-Stock R. DNA methylation and chromatin modifiers in colorectal cancer. Mol Aspects Med. 2019 Apr 24. pii: S0098-2997(19)30008-1. doi: 10.1016/j.mam.2019.04.002. [Epub ahead of print] Review. PubMed PMID: 31028771.

Hubackova S, Pribyl M, Kyjacova L, Moudra A, Dzijak R, Salovska B, Hynek S, Tambor V, Imrichova T, Svec J, Vodicka P, Vaclavikova R, Rob L, Bartek J, Hodny Z. Interferon-regulated suprabasin is essential for stress-induced stem-like cell conversion and therapy resistance of human malignancies. Mol Oncol. 2019 Mar 27.  doi: 10.1002/1878-0261.12480. [Epub ahead of print] PubMed PMID: 30919591.

Thomsen H, Chattopadhyay S, Weinhold N, Vodicka P, Vodickova L, Hoffmann P, Nöthen MM, Jöckel KH, Langer C, Hajek R, Hallmans G, Pettersson-Kymmer U, Ohlsson C, Späth F, Houlston R, Goldschmidt H, Hemminki K, Försti A. Genome-wide association study of monoclonal gammopathy of unknown significance (MGUS): comparison with multiple myeloma. Leukemia. 2019 Feb 8. doi:10.1038/s41375-019-0396-x. [Epub ahead of print] PubMed PMID: 30737484.

Obazee O, Archibugi L, Andriulli A, Soucek P, Małecka-Panas E, Ivanauskas A, Johnson T, Gazouli M, Pausch T, Lawlor RT, Cavestro GM, Milanetto AC, Di Leo M, Pasquali C, Hegyi P, Szentesi A, Radu CE, Gheorghe C, Theodoropoulos GE, Bergmann F, Brenner H, Vodickova L, Katzke V, Campa D, Strobel O, Kaiser J, Pezzilli R, Federici F, Mohelnikova-Duchonova B, Boggi U, Lemstrova R, Johansen JS, Bojesen SE, Chen I, Jensen BV, Capurso G, Pazienza V, Dervenis C, Sperti C, Mambrini A, Hackert T, Kaaks R, Basso D, Talar-Wojnarowska R, Maiello E, Izbicki JR, Cuk K, Saum KU, Cantore M, Kupcinskas J, Palmieri O, Delle Fave G, Landi S, Salvia R, Fogar P, Vashist YK, Scarpa A, Vodicka P, Tjaden C, Iskierka-Jazdzewska E, Canzian F. Germline BRCA2 K3326X and CHEK2 I157T mutations increase risk for sporadic pancreatic ductal adenocarcinoma. Int J Cancer. 2019 Jan 23. doi:10.1002/ijc.32127. [Epub ahead of print] PubMed PMID: 30672594.

Gentiluomo M, García PP, Galeotti AA, Talar-Wojnarowska R, Tjaden C, Tavano F, Strobel O, Kupcinskas J, Neoptolemos J, Hegyi P, Costello E, Pezzilli R, Sperti C, Lawlor RT, Capurso G, Szentesi A, Soucek P, Vodicka P, Lovecek M, Hackert T, Cavestro GM, Milanetto AC, Canzian F, Daniele C. Genetic variability of the ABCC2 gene and clinical outcomes in pancreatic cancer patients. Carcinogenesis. 2019 Jan 9. doi: 10.1093/carcin/bgz006. [Epub ahead of print] PubMed PMID: 30629142.

2018

Jiraskova K , Hughes DJ, Brezina S, Gumpenberger T, Veskrnova V, Buchler T, Schneiderova M, Levy M, Liska V, Vodenkova S, Di Gaetano C, Naccarati A, Pardini B, Vymetalkova V, Gsur A, Vodicka P. Functional Polymorphisms in DNA Repair Genes Are Associated with Sporadic Colorectal Cancer Susceptibility and Clinical Outcome. Int J Mol Sci. 2018 Dec 27;20(1). pii: E97. doi: 10.3390/ijms20010097.

Huyghe JR, Bien SA, Harrison TA, Kang HM, Chen S, Schmit SL, Conti DV, Qu C, Jeon J, Edlund CK, Greenside P, Wainberg M, Schumacher FR, Smith JD, Levine DM, Nelson SC, Sinnott-Armstrong NA, Albanes D, Alonso MH, Anderson K, Arnau-Collell C, Arndt V, Bamia C, Banbury BL, Baron JA, Berndt SI, Bézieau S, Bishop DT, Boehm J, Boeing H, Brenner H, Brezina S, Buch S, Buchanan DD, Burnett-Hartman A, Butterbach K, Caan BJ, Campbell PT, Carlson CS, Castellví-Bel S, Chan AT, Chang-Claude J, Chanock SJ, Chirlaque MD, Cho SH, Connolly CM, Cross AJ, Cuk K, Curtis KR, de la Chapelle A, Doheny KF, Duggan D, Easton DF, Elias SG, Elliott F, English DR, Feskens EJM, Figueiredo JC, Fischer R, FitzGerald LM, Forman D, Gala M, Gallinger S, Gauderman WJ, Giles GG, Gillanders E, Gong J, Goodman PJ, Grady WM, Grove JS, Gsur A, Gunter MJ, Haile RW, Hampe J, Hampel H, Harlid S, Hayes RB, Hofer P, Hoffmeister M, Hopper JL, Hsu WL, Huang WY, Hudson TJ, Hunter DJ, Ibañez-Sanz G, Idos GE, Ingersoll R, Jackson RD, Jacobs EJ, Jenkins MA, Joshi AD, Joshu CE, Keku TO, Key TJ, Kim HR, Kobayashi E, Kolonel LN, Kooperberg C, Kühn T, Küry S, Kweon SS, Larsson SC, Laurie CA, Le Marchand L, Leal SM, Lee SC, Lejbkowicz F, Lemire M, Li CI, Li L, Lieb W, Lin Y, Lindblom A, Lindor NM, Ling H, Louie TL, Männistö S, Markowitz SD, Martín V, Masala G, McNeil CE, Melas M, Milne RL, Moreno L, Murphy N, Myte R, Naccarati A, Newcomb PA, Offit K, Ogino S, Onland-Moret NC, Pardini B, Parfrey PS, Pearlman R, Perduca V, Pharoah PDP, Pinchev M, Platz EA, Prentice RL, Pugh E, Raskin L, Rennert G, Rennert HS, Riboli E, Rodríguez-Barranco M, Romm J, Sakoda LC, Schafmayer C, Schoen RE, Seminara D,  Shah M, Shelford T, Shin MH, Shulman K, Sieri S, Slattery ML, Southey MC, Stadler ZK, Stegmaier C, Su YR, Tangen CM, Thibodeau SN, Thomas DC, Thomas SS, Toland AE,
Trichopoulou A, Ulrich CM, Van Den Berg DJ, van Duijnhoven FJB, Van Guelpen B, van Kranen H, Vijai J, Visvanathan K, Vodicka P, Vodickova L, Vymetalkova V, Weigl K, Weinstein SJ, White E, Win AK, Wolf CR, Wolk A, Woods MO, Wu AH, Zaidi SH, Zanke BW, Zhang Q, Zheng W, Scacheri PC, Potter JD, Bassik MC, Kundaje A, Casey G, Moreno V, Abecasis GR, Nickerson DA, Gruber SB, Hsu L, Peters U. Discovery of common and rare genetic risk variants for colorectal cancer. Nat Genet. 2018 Dec 3. doi: 10.1038/s41588-018-0286-6.

Vodicka P, Musak L, Vodickova L, Vodenkova S, Catalano C, Kroupa M, Naccarati A, Polivkova Z, Vymetalkova V, Försti A, Hemminki K. Genetic variation of acquired structural chromosomal aberrations. Mutat Res. 2018 Dec;836(Pt A):13-21.doi: 10.1016/j.mrgentox.2018.05.014.

Vymetalkova V, Cervena K, Bartu L, Vodicka P. Circulating Cell-Free DNA and Colorectal Cancer: A Systematic Review. Int J Mol Sci. 2018 Oct 26;19(11). pii:E3356. doi: 10.3390/ijms19113356. Review. PubMed PMID: 30373199.

Niazi Y, Thomsen H, Smolkova B, Vodickova L, Vodenkova S, Kroupa M, Vymetalkova V, Kazimirova A, Barancokova M, Volkovova K, Staruchova M, Hoffmann P, Nöthen MM, Dušinská M, Musak L, Vodicka P, Hemminki K, Försti A. Genetic variation associated with chromosomal aberration frequency: A genome-wide association study. Environ Mol Mutagen. 2018 Oct 3. doi: 10.1002/em.22236.

Campa D, Matarazzi M, Greenhalf W, Bijlsma M, Saum KU, Pasquali C, van Laarhoven H, Szentesi A, Federici F, Vodicka P, Funel N, Pezzilli R, Bueno-de-Mesquita HB, Vodickova L, Basso D, Obazee O, Hackert T, Soucek P, Cuk K, Kaiser J, Sperti C, Lovecek M, Capurso G, Mohelnikova-Duchonova B, Khaw KT, König
AK, Kupcinskas J, Kaaks R, Bambi F, Archibugi L, Mambrini A, Cavestro GM, Landi S, Hegyi P, Izbicki JR, Gioffreda D, Zambon CF, Tavano F, Talar-Wojnarowska R, Jamroziak K, Key TJ, Fave GD, Strobel O, Jonaitis L, Andriulli A, Lawlor RT, Pirozzi F, Katzke V, Valsuani C, Vashist YK, Brenner H, Canzian F. Genetic determinants of telomere length and risk of pancreatic cancer: a PANDoRA study. Int J Cancer. 2018 Oct 16. doi: 10.1002/ijc.31928.

Vodenkova S, Jiraskova K, Urbanova M, Kroupa M, Slyskova J, Schneiderova M, Levy M, Buchler T, Liska V, Vodickova L, Vymetalkova V, Collins A, Opattova A, Vodicka P. Base excision repair capacity as a determinant of prognosis and therapy response in colon cancer patients. DNA Repair (Amst). 2018 Oct 1. pii:S1568-7864(18)30070-3. doi: 10.1016/j.dnarep.2018.09.006.

Kral J , Korenkova V, Novosadova V, Langerova L, Schneiderova M, Liska V, Levy  M, Veskrnova V, Spicak J, Opattova A, Jiraskova K, Vymetalkova V, Vodicka P, Slyskova J. Expression profile of miR-17/92 cluster is predictive of treatment response in rectal cancer. Carcinogenesis. 2018 Oct 1. doi:10.1093/carcin/bgy100.

Thiele JA, Hosek P, Kralovcova E, Ostasov P, Liska V, Bruha J, Vycital O, Rosendorf J, Opattova A, Horak J, Kralickova M, Vodicka P, Pitule P. lncRNAs in Non-Malignant Tissue Have Prognostic Value in Colorectal Cancer. Int J Mol Sci. 2018 Sep 8;19(9). pii: E2672. doi: 10.3390/ijms19092672.

Huhn S, da Silva Filho MI, Sanmuganantham T, Pichulik T, Catalano C, Pardini B, Naccarati A, Polakova-Vymetálkova V, Jiraskova K, Vodickova L, Vodicka P, Löffler MW, Courth L, Wehkamp J, Din FVN, Timofeeva M, Farrington SM, Jansen L, Hemminki K, Chang-Claude J, Brenner H, Hoffmeister M, Dunlop MG, Weber ANR, Försti A. Coding variants in NOD-like receptors: An association study on risk and survival of colorectal cancer. PLoS One. 2018 Jun 21;13(6):e0199350. doi:10.1371/journal.pone.0199350.

Catalano C, da Silva Filho MI, Jiraskova K, Vymetalkova V, Levy M, Liska V, Vycital O, Naccarati A, Vodickova L, Hemminki K, Vodicka P, Weber ANR, Försti A. Short article: Influence of regulatory NLRC5 variants on colorectal cancer survival and 5-fluorouracil-based chemotherapy. Eur J Gastroenterol Hepatol. 2018 Aug;30(8):838-842. doi: 10.1097/MEG.0000000000001154.

IARC Monographs Vol 121 Group. Carcinogenicity of quinoline, styrene, and styrene-7,8-oxide. Lancet Oncol. 2018 Apr 18. pii: S1470-2045(18)30316-4. doi:10.1016/S1470-2045(18)30316-4.

Catalano, C., da Silva Filho, M. I., Frank, C., Jiraskova, K., Vymetalkova, V., Levy, M., Liska, V., Vycital, O., Naccarati, A., Vodickova, L., Hemminki, K., Vodicka, P.,Weber, A. N. R., Försti, A.: (2018). Investigation of single and synergic effects of NLRC5 and PD-L1 variants on the risk of colorectal cancer. PLoS ONE13(2).

Klein, A. P., Wolpin, B. M., Risch, H. A., Stolzenberg-Solomon, R. Z., Mocci, E., Zhang, M., Canzian, F., Childs, E.J., Hoskins, J.W., Jermusyk, A., Zhong, J., Chen, F., Albanes, D., Andreotti, G., Arslan, A.A., Babic, A., Bamlet, W.R., Beane-Freeman, L., Berndt, S.I., Blackford, A., Borges, M., Borgida, A., Bracci, P.M., Brais, L., Brennan, P., Brenner, H., Bueno-de-Mesquita, B., Buring, J., Campa, D., Capurso, G., Cavestro, G.M., Chaffee, K.G., Chung, C.C., Cleary, S., Cotterchio, M., Dijk, F., Duell, E.J., Foretova, L., Fuchs, C., Funel, N., Gallinger, S., M. Gaziano, J.M., Gazouli, M., Giles, G.G., Giovannucci, E., Goggins, M., Goodman, G.E., Goodman, P.J., Hackert, T., Haiman, C., Hartge, P., Hasan, M., Hegyi, P., Helzlsouer, K.J., Herman, J., Holcatova, I., Holly, E.A., Hoover, R., Hung, R.J., Jacobs, E.J., Jamroziak, K., Janout, V., Kaaks, R., Khaw, K.T., Klein, E.A., Kogevinas, M., Kooperberg, C., Kulke, M.H., Kupcinskas, J., Kurtz, R.J., Laheru, D., Landi, S., Lawlor, R.T., Lee, I.M., LeMarchand, L., Lu, L., Malats, N., Mambrini, A., Mannisto, S., Milne, R.L., Mohelníková-Duchoňová, B., Neale, R.E., Neoptolemos, J.P., Oberg, A.L., Olson, S.H., Orlow, I., Pasquali, C., Patel, A.V., Peters, U., Pezzilli, R., Porta, M., Real, F.X., Rothman, N., Scelo, G., Sesso, H.D., Severi, G., Shu, X.O., Silverman, D., Smith, J.P., Soucek, P., Sund, M., Talar-Wojnarowska, R., Tavano, F., Thornquist, M.D., Tobias, G.S., Van Den Eeden, S.K., Vashist, Y., Visvanathan, K., Vodicka, P., Wactawski-Wende, J., Wang, Z., Wentzensen, N., White, E., Yu, H., Yu, K., Zeleniuch-Jacquotte, A., Zheng, W., Kraft, P., Li, D., Chanock, S., Obazee, O., Petersen, G.M., Amundadottir, L. T. (2018). Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Nature Communications9(1), 556.

Rejhova, A., Opattova, A., Cumova, A.,  Slíva, D., & Vodicka, P. (2018). Natural compounds and combination therapy in colorectal cancer treatment. European Journal of Medicinal Chemistry144, 582–594.

2017

Barontini, J., Antinucci, M., Tofanelli, S., Cammalleri, M., Dal Monte, M., Gemignani, F., Vodička, P., Marangoni, R., Vodičková, L., Kupcinskas, J., Vymetálková, V., Försti, A., Canzian, F., Stein, A., Moreno, V., Mastrodonato, N., Tavano, F., Panza, A., Barale, R., Landi, S., Campa, D.: (2017) Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer. BMC Gastroenterology. 17: 104.

Carrai, M., Campa, D., Vodička, P., Flamini, R., Martelli, I., Slyšková, J., Jirásková, K., Rejhová, A., Vodenková, S., Canzian, F., Bertelli, A., Dalla Vedova, A., Bavaresco, L., Vodičková, L., Barale, R.: (2017) Association between taste receptor (TAS) genes and the perception of wine characteristics. Scientific Reports. 7: 9239.

De Santi, Ch., Pucci, P., Bonotti, A., Melaiu, O., Cipollini, M., Silvestri, R., Vymetálková, V., Barone, E., Paolicchi, E., Corrado, A., Lepori, I., Dell'Anno, I., Pelle, L., Vodička, P., Mutti, L., Foddis, R., Cristaudo, A., Gemignani, F., Landi, S.: (2017) Mesothelin promoter variants are associated with increased soluble mesothelin-related peptide levels in asbestos-exposed individuals. Occupational and Environmental Medicine. 74 (6): 457-464.

Kroupa, M. , Polívková, Z., Rachakonda, S., Schneiderová, M., Vodenková, S., Buchler, T., Jirásková, K., Urbanová, M., Vodičková, L., Hemminki, K., Kumar, R., Vodička, P.: (2017) Bleomycin-induced chromosomal damage and shortening of telomeres in peripheral blood lymphocytes of incident cancer patients. Genes Chromosomes & Cancer. IN PRESS

Mohelníková-Duchoňová, B., Strouhal, O., Hughes, D. J., Holcatová, I., Oliverius, M., Kala, Z., Campa, D., Rizzato, C., Canzian, F., Pezzilli, R., Talar-Wojnarowska, R., Malecka-Panas, E., Sperti, C., Sperti, C., Federico Zambon, C., Pedrazzoli, S., Fogar, P., Milanetto, A.C., Capurso, G., Fave, G.D., Valente, R., Gazouli, M., Malleo, G., Lawlor, R.T., Strobel, O., Hackert, T., Giese, N., Vodička, P., Vodičková, L., Landi, S., Tavano, F., Gioffreda, D., Piepoli, A., Pazienza, V., Mambrini, A., Pedata, M., Cantore, M., Bambi, F., Ermini, S., Funel, N., Lemstrová, R., Souček, P.: (2017) SLC22A3 polymorphisms do not modify pancreatic cancer risk, but may influence overall patient survival. Scientific Reports. 7, 43812.

Schneiderová, B., Naccarati, A., Pardini, B., Rosa, F., Di Gaetano, C., Jirásková, K., Opattová, A., Levý, M., Veskrna, K., Veškrnová, V., Buchler, T., Landi, S., Vodička, P., Vymetálková, V.: (2017) MicroRNA-binding site polymorphisms in genes involved in colorectal cancer etiopathogenesis and their impact on disease prognosis. Mutagenesis. 32(5): 533-542.

Schormair, B., Zhao, Ch., Bell, S., Tilch, E., Salminen, A.V., Putz, B., Dauvilliers, Y., Stefani, A., Högl, B., Poewe, W., Kemlink, D., Šonka, K., Bachmann, C. G., Paulus, W., Trenkwalder, C., Oertel, W., Hornyak, M., Teder-Laving, M., Metspalu, A., Hadjigeorgiou, G.M., Polo, O., Fietze, I., Ross, O.A., Wszolek, Z., Butterworth, A.S., Soranzo, N., Ouwehand, W. H., Roberts, D.J., Danesh, J., Allen, R.P., Earley, Ch.J., Ondo, W.G., Xiong, L., Montplaisir, J., Gan-Or, Z., Perola, M., Vodička, P., Dina, Ch., Franke, A., Tittmann, L., Stewart, A.F.R., Shah, S.H., Gieger, Ch., Peters, A., Rouleau, G.A., Berger, K., Oexle, K., Di Angelantonio, E., Hinds, D.A., Müller-Myhsok, B., Winkelmann, J.: (2017) Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. Lancet Neurology. 16 (11): 898-907.

Schubert, S.A., Ruano, D., Elsayed, F.A., Boot, A., Crobach, S., Sarasqueta, A.F., Wolffenbuttel, B., van der Klauw, M.M., Oosting, J., Tops, C.M., van Eijk, R., Vasen, H.F., Vossen, R.H., Nielsen, M., Castellví-Bel, S., Ruiz-Ponte, C., Tomlinson, I., Dunlop, M.G., Vodička, P., Wijnen, J.T., Hes, F.J., Morreau, H., de Miranda, N.F., Sijmons, R.H., van Wezel, T.: (2017) Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia. British Journal of Cancer. 117 (8): 1215-1223.

Thomsen, H., Campo, Ch., Weinhold, N., da Silva Filho, M.I., Pour, L., Gregora, E., Vodička, P., Vodičková, L., Hoffmann, P., Nöthen, M.M., Jöckel, K.H., Langer, Ch., Hájek, R., Goldschmidt, H., Hemminki, K., Försti, A.: (2017) Genomewide association study on monoclonal gammopathy of unknown significance (MGUS). European Journal of Haematology. 99 (1): 70-79.

Vymetálková, V. , Pardini, B., Rosa, F., Jirásková, K., Di Gaetano, C., Bendová, P., Levy, M., Veskrnová, V., Buchler, T., Vodičková, L., Naccarati, A., Vodička, P.: (2017) Polymorphisms in microRNA binding sites of mucin genes as predictors of clinical outcome in colorectal cancer patients. Carcinogenesis, 38(1): 28-39.

Wultsch, G., Nersesyan, A., Kundi, M., Mišík, M., Setayesh, T., Waldherr, M., Vodička, P., Vodičková, L., Knasmüller, S.: (2017) Genotoxic and Cytotoxic Effects in Exfoliated Buccal and Nasal Cells of Chromium and Cobalt Exposed Electroplaters. Journal of Toxicology and Environmental Health. Part A. 80(13-15): 651-660.

2016

Campa, D., Pastore, M., Gentiluomo, M., Talar-Wojnarowská, R., Kupcinskas, J., Malecka-Panas, E., Neoptolemos, J.P., Niesen, W., Vodička, P., Delle Fave, G., Bas Bueno-de-Mesquita, H., Gazouli M., Pacetti, P., Di Leo, M., Ito, H., Klüter, H., Souček, P., Corbo, V., Yamao, K., Hosono, S., Kaaks, R., Vashist, Y., Gioffreda, D., Strobel, O., Shimizu, Y., Dijk, F., Andriulli, A., Ivanauskas, A., Bugert, P., Tavano, F., Vodičková, L., Federico Zambon, C., Lovecek, M., Landi, S., Key, T.J., Boggi, U., Pezzilli, R., Jamroziak, K., Mohelnikova-Duchonová, B., Mambrini, A., Bambi, F., Busch, O., Pazienza, V., Valente, R., Theodoropoulos, G.E., Hackert, T., Capurso, G., Martina Cavestro, G., Pasquali, C., Basso, D., Sperti, C., Matsuo, K., Büchler, M., Khaw, K.T., Izbicki, J., Costello, E., Katzke, V., Michalski, C., Stepien, A., Rizzato, C., Canzian, F.: (2016) Functional single nucleotide polymorphisms within the cyclin-dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk. Oncotarget, IN PRESS

Elsnerová, K., Mohelniková-Duchonová, B., Čeřovská, E., Ehrlichová, M., Gut, I., Rob, L., Skapa, P., Hruda, M., Bartaková, A., Bouda, J., Vodička, P., Souček, P., Václavíková, R.,: (2016) Gene expression of membrane transporters: Importance for prognosis and progression of ovarian carcinoma. Oncol. Rep., 35(4): 2159-2170.

Försti, A., Frank, C., Smolková, B., Kazimirová, A., Barancoková, M., Vymetálková, V., Kroupa, M., Naccarati, A., Vodičková, L., Buchancová, J., Dusinská, M., Musak, L., Vodička, P., Hemminki, K.: (2016) Genetic variation in the major mitotic checkpoint genes associated with chromosomal aberrations in healthy humans. Cancer Lett., 380(2):442-446.

Kořenková, V., Slyšková, J., Novosadová, V., Pizzamiglio, S., Langerová, L., Bjorkman, J., Vyčítal, O., Liska, V., Levy, M., Veskrna, K., Vodička, P., Vodičková, L., Kubista, M., Verderio, P.: (2016)The focus on sample quality: Influence of colon tissue collection on reliability of qPCR data. Sci Rep, 6: 29023.

Kunická, T., Procházka, P., Krus, I., Bendová, P., Protivová, M., Susová, S., Hlaváč, V., Liska, V., Novák, P., Schneiderová, M., Pitule, P., Bruha, J., Vyčítal, O., Vodička, P., Souček, P.: (2016) Molecular profile of 5-fluorouracil pathway genes in colorectal carcinoma. BMC Cancer, 16(1):795.

Naccarati, A. , Rosa, F., Vymetálková V., Barone, E., Jirásková, K., Di Gaetano, C., Novotný, J., Levy, M., Vodičková, L., Gemignani, F., Buchler, T., Landi, S., Vodička, P., Pardini, B.: (2016) Double-strand break repair and colorectal cancer: gene variants within 3' UTRs and microRNAs binding as modulators of cancer risk and clinical outcome. Oncotarget, 7(17): 23156-23169.

Vodička, P. , Musak, L., Fiorito, G., Vymetálková, V., Vodičková, L., Naccarati, A.: (2016) DNA and chromosomal damage in medical workers exposed to anaesthetic gases assessed by the lymphocyte cytokinesis-block micronucleus (CBMN) assay. A critical review. Mutat. Res.-Rev. Mutat. Res., 770(Pt A): 26-34.

Vodička, P., Pardini, B., Vymetálková, V., Naccarati, A.: (2016) Polymorphisms in Non-coding RNA Genes and Their Targets Sites as Risk Factors of Sporadic Colorectal Cancer. Adv.Exp.Med.Biol., 937: 123-149.

Vymetálková, V. , Pardini, B., Rosa, F., Jirásková, K., Di Gaetano, C., Bendová, P., Levy, M., Veskrnová, V., Buchler, T., Vodičková, L., Naccarati,A., Vodička, P.: (2016) Polymorphisms in microRNA binding sites of mucin genes as predictors of clinical outcome in colorectal cancer patients. Carcinogenesis, IN PRESS.

Vymetálková, V., Vodička, P. , Pardini, B., Rosa, F., Levy, M., Schneiderová, M., Liska, V., Vodičková, L., Nilsson, T.K., Farkas, S.A.: (2016) Epigenome-wide analysis of DNA methylation reveals a rectal cancer-specific epigenomic signature. Epigenomics, 8(9): 1193-1207.

Zhang, M., Wang, Z., Obazee, O., Jia, J., Childs, E.J., Hoskins, J., Figlioli, G., Mocci, E., Collins, I., Chung, C.C., Hautman, C., Arslan, A.A., Beane-Freeman, L., Bracci, P.M., Buring, J., Duell, E.J., Gallinger, S., Giles, G.G., Goodman, G.E., Goodman, P.J., Kamineni, A., Kolonel, L.N., Kulke, M.H., Malats, N., Olson SH, Sesso HD, Visvanathan K, White E, Zheng W, Abnet CC, Albanes D, Andreotti, G., Brais, L., Bueno-de-Mesquita, H.B., Basso, D., Berndt, S.I., Boutron-Ruault, M.C., Bijlsma, M.F., Brenner, H., Burdette, L., Campa, D., Caporaso, N.E., Capurso, G., Cavestro, G.M., Cotterchio, M., Costello, E., Elena, J., Boggi, U., Gaziano, J.M., Gazouli, M., Giovannucci, E.L., Goggins, M., Gross, M., Haiman, C.A., Hassan, M., Helzlsouer, K.J., Hu, N., Hunter, D.J., Iskierka-Jazdzewska, E., Jenab, M., Kaaks, R., Key, T.J., Khaw, K.T., Klein, E.A., Kogevinas, M., Krogh, V., Kupcinskas, J., Kurtz, R.C., Landi, M.T., Landi, S., Le Marchand, L., Mambrini, A., Mannisto, S., Milne, R.L., Neale, R.E., Oberg, A.L., Panico, S., Patel, A.V., Peeters, P.H., Peters, U., Pezzilli, R., Porta, M., Purdue, M., Quiros, J.R., Riboli, E., Rothman, N., Scarpa, A., Scelo, G., Shu, X.O., Silverman, D.T., Souček, P., Strobel, O., Sund, M., Małecka-Panas, E., Taylor, P.R., Tavano, F., Travis, R.C., Thornquist, M., Tjønneland, A., Tobias, G.S., Trichopoulos, D., Vashist, Y., Vodička, P., Wactawski-Wende, J., Wentzensen, N., Yu, H., Yu, K., Zeleniuch-Jacquotte, A., Kooperberg, C., Risch, H.A., Jacobs, E.J., Li, D., Fuchs, C., Hoover, R., Hartge, P., Chanock, S.J., Petersen, G.M., Stolzenberg-Solomon, R.S., Wolpin, B.M., Kraft, P., Klein, A.P., Canzian, F., Amundadottir, L.T.: (2016) Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21. Oncotarget, IN PRESS

2015

Aherne, S.T., Madden, S.F., Hughes, D.J., Pardini, B., Naccarati, A., Levy, M., Vodička, P., Neary, P., Dowling, P., Clynes, M.: (2015) Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression. BMC Cancer. 15: 329.

Campa, D., Rizzato, C., Stolzenberg-Solomon, R., Pacetti, P., Vodička, P., Cleary, S.P., Capurso, G., Bueno-de-Mesquita, H.B., Werner, J., Gazouli, M., Butterbach, K., Ivanauskas, A., Giese, N., Petersen, G.M., Fogar, P., Wang, Z., Bassi, C., Ryska, M., Theodoropoulos, G.E., Kooperberg, C., Li, D., Greenhalf, W., Pasquali, C., Hackert, T., Fuchs, C.S., Mohelnikova-Duchonova, B., Sperti, C., Funel, N., Dieffenbach, A.K., Wareham, N.J., Buring, J., Holcátová, I., Costello, E., Zambon, C.F., Kupcinskas, J., Risch, H.A., Kraft, P., Bracci, P.M., Pezzilli, R., Olson, S.H., Sesso, H.D., Hartge, P., Strobel, O., Małecka-Panas, E., Visvanathan, K., Arslan, A.A., Pedrazzoli, S., Souček, P., Gioffreda, D., Key, T.J., Talar-Wojnarowská, R., Scarpa, A., Mambrini, A., Jacobs, E.J., Jamroziak, K., Klein, A., Tavano, F., Bambi, F., Landi, S., Austin, M.A., Vodičková, L., Brenner, H., Chanock, S.J., Delle Fave, G., Piepoli, A., Cantore, M., Zheng, W., Wolpin, B.M., Amundadottir, L.T., Canzian, F.: (2015) TERT gene harbors multiple variants associated with pancreatic cancer susceptibility. Int J Cancer. 1;137(9):2175-2183.

Childs, E.J., Mocci, E., Campa, D., Bracci, P.M., Gallinger, S., Goggins, M., Li, D., Neale, R.E., Olson, S.H., Scelo, G., Amundadottir, L.T., Bamlet, W.R., Bijlsma, M.F., Blackford, A., Borges, M., Brennan, P., Brenner, H., Bueno-de-Mesquita, H.B., Canzian, F., Capurso, G., Cavestro, G.M., Chaffee, K.G., Chanock, S.J., Cleary, S.P., Cotterchio, M., Foretová, L., Fuchs, C., Funel, N., Gazouli, M., Hassan, M., Herman, J.M., Holcatová, I., Holly, E.A., Hoover, R.N., Hung, R.J., Janout, V., Key, T.J., Kupcinskas, J., Kurtz, R.C., Landi, S., Lu, L., Malecka-Panas, E., Mambrini, A., Mohelniková-Duchonová, B., Neoptolemos, J.P., Oberg, A.L., Orlow, I., Pasquali, C., Pezzilli, R., Rizzato, C., Saldia, A., Scarpa, A., Stolzenberg-Solomon, R.Z., Strobel, O., Tavano, F., Vashist, Y.K., Vodička, P., Wolpin, B.M., Yu, H., Petersen, G.M., Risch, H.A., Klein, A.P.: (2015) Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer. Nat Genet. 47(8):911-916.

Dowling, P., Hughes, D. J., Larkin, A. M., Meiller, J., Henry, M., Meleady, P., Lynch, V., Pardini, B., Naccarati, A., Levy, M., Vodička, P., Neary, P., Clynes, M.: (2015) Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer. Clin. Chim. Acta. 441: 133-141.

Hemminki, K., Frank, C., Försti, A., Musak, L., Kazimirova, A., Barancokova, M., Horska, A., Vymetalková, V., Šmerhovský, Z.,Naccarati, A., Souček, P., Vodičková, L., Buchancová, J., Smolková, B., Dušinská, M., Vodička, P.: (2015) Metabolic gene variants associated with chromosomal aberrations in healthy humans. Gene Chromosomes Cancer. 54(4): 260-266.

Hemminki, K., Rachakonda, S., Musak, L., Vymetálková, V., Halasová, E., Försti, A., Vodičková, L., Buchancová, J., Vodička, P., Kumar, R.: (2015) Telomere length in circulating lymphocytes: Association with chromosomal aberrations. Gene Chromosomes Cancer. 54(3): 194-196.

Pardini, B., Rosa, F., Naccarati, A., Vymetálková, V., Ye, Y., Wu, X., di Gaetano, C., Buchler, T., Novotný, J., Matullo, G., Vodička, P.: (2015) Polymorphisms in microRNA genes as predictors of clinical outcomes in colorectal cancer patients. Carcinogenesis. 31(6): 82-86.

Slyšková, J., Cordero, F., Pardini, B., Korenková, V., Vymetalková, V., Bielik, L., Vodičková, L., Pitule, P., Liska, V., Matejka, V. M., Levy, M., Buchler, T., Kubista, M., Naccarati, A., Vodička, P.: (2015) Post-treatment recovery of suboptimal DNA repair capacity and gene expression levels in colorectal cancer patients. Mol. Carcinog., 54 (9): 769-778.

Vodenková, S., Polivková, Z., Musak, L., Šmerhovský, Z., Zoubková, H., Sytarová, S., Kavcová, E., Halasová, E., Vodičková, L., Jirásková, K., Svoboda, M., Ambrus, M., Hemminki, K., Vodička, P.: (2015) Structural chromosomal aberrations as potential risk markers in incident cancer patients. Mutagenesis.30(4):557-563.

Vodička, P., Caja, F., Vymetálková, V., Procházka, P., Vodičková, L., Schwarzová, L., Slyšková, J., Kumar, R., Schneiderová, M.: (2015) Ile68Met germline variant in exon 2 of the mutL homolog 1 gene in a colorectal cancer patient. Oncol. Lett. 9(1): 183-186.

Vodička, P., Musak, L., Frank, C., Kazimirova, A., Vymetálková, V., Barancoková, M., Smolková, B., Dzupinková, Z., Jirasková, K., Vodenková, S., Kroupa, M., Osina, O., Naccarati, A., Palitti, F., Försti, A., Dusinská, M., Vodičková, L., Hemminki, K.: (2015) Interactions of DNA repair gene variants modulate chromosomal aberrations in healthy subjects. Carcinogenesis.36(11): 1299-1306.

Vymetálková, V., Souček, P., Kunicka, T., Jirásková, K., Brynychova, V., Pardini, B., Novosadova, V., Polivkova, Z., Kubackova, K., Kozevnikovova, R., Ambrus, M., Vodičková, L., Naccarati, A., Vodička, P.: (2015) Genotype and Haplotype Analyses of TP53 Gene in Breast Cancer Patients: Association with Risk and Clinical Outcomes. PLoS One. 10(7): e0134463.

2014

Farkas, S. A., Vymetálková, V., Vodičková, L., Vodička, P., Nilsson, T. K.: (2014) DNA methylation changes in genes frequently mutated in sporadic colorectal cancer and in the DNA repair and Wnt/β-catenin signaling pathway genes. Epigenomics 6(2): 179-191.

Huhn, S., Bevier, M., Pardini, B., Naccarati, A., Vodičková, L., Novotny, J., Vodička, P., Hemminki, K., Försti, A.: (2014) Colorectal cancer risk and patients' survival: influence of polymorphisms in genes somatically mutated in colorectal tumors. Cancer Causes Control. 25(6): 759-769.

Kunická, T., Václavíková, R., Hlaváč, V., Vrána, D., Pecha, V., Rauš, K., Trnková, M., Kubáčková, K., Ambruš, M., Vodičková, L., Vodička, P., Souček, P.: (2014) Non-Coding Polymorphisms in Nucleotide Binding Domain 1 in ABCC1 Gene Associate with Transcript Level and Survival of Patients with Breast Cancer. PLoS One 9(7): e101740.

Lu, S., Pardini, B., Cheng, B., Naccarati, A., Huhn, S., Vymetálková, V., Vodičková, L., Buchler, T., Hemminki, K., Vodička, P., Försti, A.: (2014) Single Nucleotide Polymorphisms within Interferon Signaling Pathway Genes Are Associated with Colorectal Cancer Susceptibility and Survival. PLoS One 9(10): e111061.

Makovický, P., Tumova, E., Volek, Z., Makovický, P., Vodičková, L., Slyšková, J., Svoboda, M., Rejhová, A., Vodička, P., Samasca, G., Králová, A., Nagy, M., Mydlarova-Blascaková, M., Poracova, J.: (2014) Histopathological aspects of liver under variable food restriction: Has the intense one-week food restriction a protective effect on non-alcoholic-fatty-liver-disease (NAFLD) development?Pathol. Res. Pract. 210(12): 855-862.

Makovický, P., Tůmová, E., Volek, Z., Makovický, P., Vodička, P.: (2014) Histological aspects of the small intestine under variable feed restriction: The effects of short and intense restriction on a growing rabbit model. Exp. Ther. Med. 8(5): 1623-1627.

Pardini, B., Verderio, P., Pizzamiglio, S., Nici, C., Maiorana, M. V., Naccarati, A., Vodičková, L., Vymetálková, V., Veneroni, S., Daidone, M. G., Ravagnani, F., Bianchi, T., Bujenda, L., Carracedo, A., Castells, A., Ruiz-Ponte, C., Morreau, H., Howarth, K., Jones, A., Castellvı´-Bel, S., Li L., Tomlinson, I., Van Wezel, T., Vodička, P., Radice, P., Peterlongo, P., the EPICOLON Consortium: (2014) Association between CASP8 –652 6N Del Polymorphism (rs3834129) and Colorectal Cancer Risk: Results from a Multi-Centric Study. PLoS ONE 9(3): e91310.

Pardini, B., Bermejo, J. L., Naccarati, A., Di Gaetano, C., Rosa, F., Legrand, C., Novotny, J., Vodička, P., Kumar, R.: (2014) Inherited variability in a master regulator polymorphism (rs4846126) associates with survival in 5-FU treated colorectal cancer patients.Mutat. Res.-Fundam. Mol. Mech. Mutagen. 766-767: 7-13.

Svoboda, M., Slyšková, J., Schneiderova, M., Makovicky, P., Bielik, L., Levy, M., Lipska, L., Hemmelova, B., Kala, Z., Protivankova, M., Vycital, O., Liska, V., Schwarzova, L., Vodičková, L, Vodička P.: (2014) HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients. Carcinogenesis. 35(7): 1510-1515.

Slyšková, J., Lorenzo, Y., Karlsen, A., Carlsen, M. H., Novosadová, V., Blomhoff, R., Vodička, P., Collins, A. R.: (2014) Both genetic and dietary factors underlie individual differences in DNA damage levels and DNA repair capacity. DNA Repair (Amst). 16 :66-73.

Slyšková, J., Langie, S, A. , Collins, A. R., Vodička, P.: (2014) Functional evaluation of DNA repair in human biopsies and their relation to other cellular biomarkers. Front Genet. 5: 116.

Švec, J., Schwarzová, L., Janošíková, B., Štekrová, J., Mandys, V., Kment, M., Vodička, P.: (2014) Synchronous gastric and sebaceous cancers, a rare manifestation of MLH1-related Muir-Torre syndrome. Int. J. Clin. Exp. Pathol. 7(8): 5196-5202.

Vymetálková, V., Pardini, B., Rosa, F., Di Gaetano, C., Novotny, J., Levy, M., Buchler, T., Slyšková, J., Vodičková, L., Naccarati, A., Vodička, P.: (2014) Variations in mismatch repair genes and colorectal cancer risk and clinical outcome. Mutagenesis. 29(4): 259-265.

Vymetálková, V., Slyšková, J., Korenková, V., Bielik, L., Langerová, L., Procházka, P., Rejhová, A., Schwarzová, L., Pardini, B.,Naccarati, A., Vodička, P.: (2014) Molecular characteristics of mismatch repair genes in sporadic colorectal tumors in Czech patients BMC Med. Genet. 15(1) :17.

Wolpin, B. M., Rizzato, C., Kraft, P., Kooperberg, C., Petersen, G. M., Wang, Z., Arslan, A. A., Beane-Freeman, L., Bracci, P.M., Buring, J., Canzian, F., Duell, E. J., Gallinger, S., Giles, G. G., Goodman, G. E., Goodman, P. J., Jacobs, E. J., Kamineni, A., Klein, A. P., Kolonel, L. N., Kulke, M. H., Li, D., Malats, N., Olson, S. H., Risch, H. A., Sesso, H. D., Visvanathan, K., White, E., Zheng, W., Abnet, C. C., Albanes, D., Andreotti, G., Austin, M. A., Barfield, R., Basso, D., Berndt, S. I., Boutron-Ruault, M. C., Brotzman, M., Büchler, M. W., Bueno-de-Mesquita, H. B., Bugert, P., Burdette, L., Campa, D., Caporaso, N. E., Capurso, G., Chung, C., Cotterchio, M., Costello, E., Elena, J., Funel, N., Gaziano, J. M., Giese, N. A., Giovannucci, E. L., Goggins, M., Gorman, M. J., Gross, M., Haiman, C. A., Hassan, M., Helzlsouer, K. J., Henderson, B. E., Holly, E. A., Hu, N., Hunter, D. J., Innocenti, F., Jenab, M., Kaaks, R., Key, T. J., Khaw, K. T., Klein, E. A., Kogevinas, M., Krogh, V., Kupcinskas, J., Kurtz, R. C., LaCroix, A., Landi, M. T., Landi, S., Le Marchand, L., Mambrini, A., Mannisto, S., Milne, R. L., Nakamura, Y., Oberg, A. L., Owzar, K., Patel, A. V., Peeters, P. H., Peters, U., Pezzilli, R., Piepoli, A., Porta, M., Real, F. X., Riboli, E., Rothman, N., Scarpa, A., Shu, X. O., Silverman, D. T., Soucek, P., Sund, M., Talar-Wojnarowska, R., Taylor, P. R., Theodoropoulos, G. E., Thornquist, M., Tjønneland, A., Tobias, G. S., Trichopoulos, D., Vodička, P., Wactawski-Wende, J., Wentzensen, N., Wu, C., Yu, H., Yu, K., Zeleniuch-Jacquotte, A., Hoover, R., Hartge, P., Fuchs, C., Chanock, S. J., Stolzenberg-Solomon, R. S., Amundadottir, L. T.: (2014) Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Nature Genet. 46(9): 994-1000.

2013

Azqueta, A., Langie, S. A., Slyšková, J., Collins, A. R.: (2013) Measurement of DNA base and nucleotide excision repair activities in mammalian cells and tissues using the comet assay - A methodological overview. DNA Repair (Amst) 12: 1007-1010.

Campa, D., Rizzato, C., Capurso, G., Giese, N., Funel, N., Greenhalf, W., Souček, P., Gazouli, M., Pezzilli, R, Pasquali, C., Talar-Wojnarowska, R., Cantore, M., Andriulli, A., Scarpa, A., Jamroziak, K., Delle Fave, G., Costello, E., Khaw, K. T., Heller, A., Key, T. J., Theodoropoulos, G., Malecka-Panas, E., Mambrini, A., Bambi, F., Land, S., Pedrazzoli, S., Bassi, C., Pacetti, P., Piepoli, A., Tavano, F., di Sebastiano, P., Vodičková, L., Basso, D., Plebani, M., Fogar, P., Büchler, M. W., Bugert, P., Vodička, P., Boggi, U., Neoptolemos, J. P., Werner, J., Canzian, F.: (2013) Genetic susceptibility to pancreatic cancer and its functional characterisation: The PANcreatic Disease ReseArch (PANDoRA) consortium. Dig. Liver Dis. 45(2): 95-99.

Campa, D., Rizzato, C., Bauer, A. S., Werner, J., Capurso, G., Costello, E., Talar-Wojnarowska, R., Jamroziak, K., Pezzilli, R., Gazouli, M., Khaw, K. T., Key, T. J., Bambi, F., Mohelnikova-Duchonova, B., Heller, A., Landi, S., Vodičková, L., Theodoropoulos, G., Bugert, P.,Vodička, P., Hoheisel, J., Delle Fave, G., Neoptolemos, J., Souček, P., Buchler, M. W., Giese, N. A., Canzian F.: (2013) Lack of replication of seven pancreatic cancer susceptibility lociidentified in two Asian populations. Cancer Epidemiol. Biomarkers Prev.22(2): 320-323.

Lu, S., Bevier, M., Huhn, S., Sainz, J., Lascorz, J., Pardini, B., Naccarati, A., Vodičková, L., Novotný, J., Hemminki, K., Vodička, P., Försti A.: (2013) Genetic variants in C-type lectin genes are associated with colorectal cancer susceptibility and clinical outcome.Int. J. Cancer. 133(10): 2325-2333.

Makovicky, P., Rimarova, K., Boor, A., Makovicky, P., Vodička, P., Samasca, G., Kruzliak, P.: (2013) Correlation between antibodies and histology in celiac disease: Incidence of celiac disease is higher than expected in the pediatric population. Mol. Med. Rep.8(4): 1079-1083.

Mušák, L., Šmerhovský, Z., Halasová, E., Osina, O., Letková, L., Vodičková, L., Poláková, V., Buchancová, J., Hemminki, K.,Vodička, P.: (2013) Chromosomal damage among medical staff occupationally exposed to volatile anesthetics, antineoplastic drugs, and formaldehyde. Scand. J. Work Environ. Health. 39(6): 618-630.

Pardini, B., Rosa, F., Barone, E., Di Gaetano, C., Slyšková, J., Novotný, J., Levy, M., Garritano, S., Vodičková, L., Buchler, T., Gemignani, F., Landi, S., Vodička, P., Naccarati, A.: (2013) Variation within 3' UTRs of base excision repair genes and response to therapy in colorectal cancer patients: a potential modulation of microRNAs binding. Clin. Cancer Res. 19(21): 6044-6056.

Picelli, S., Bermejo, J. L., Change-Claude, J., Hoffmeister, M., Fernández-Rozadilla, C., Carracedo, A., Castells, A., Castellví-Bel, S.,Naccarati, A., Pardini, B., Vodičková, L., Hüller, H., Talseth-Palmer, B. A., Stibbard, G., Peterlongo, P., Nici, C., Veneroni, S., Li, L., Casey, G., Tenesa, A., Farrington, S. M., Tomlinson, I., Moreno, V., van Wezel, T., Wijnen, J., Dunlop, M., Radice, P., Scott, R. J.,Vodička, P., Ruiz-Ponte, C., Brenner, H., Buch, S., Völzke, H., Hampe, J., Schafmayer, C., Lindblom, A.: Meta-Analysis of Mismatch Repair Polymorphisms within the Cogent Consortium for Colorectal Cancer Susceptibility; PLoS One 8(9): e72091.

Poláková-Vymetálková, V., Vannucci, L., Korenková, V., Procházka, P., Slyšková, J., Vodičková, L., Rusňáková, V., Bielik, L., Burocziová, M., Rossmann., P., Vodička, P.: (2013) Evaluation of tumor suppressor gene expressions and aberrant methylation in the colon of cancer-induced rats: a pilot study. Mol. Biol. Rep. 40(10): 5921-5929.

Procházka, P., Hrabeta, J., Vicha, A., Cipro, S., Stejskalová, E., Musil, Z., Vodička, P., Eckschlager, T.: (2013) Changes in MYCN expression in human neuroblastoma cell lines following cisplatin treatment may not be related to MYCN copy numbers. Oncol. Rep. 29(6):2415-2421.

Rizzato, C., Campa, D., Pezzilli, R., Souček, P., Greenhalf, W., Capurso, G., Talar-Wojnarowska, R., Heller, A., Jamroziak, K., Khaw, K. T., Key, T. J., Bambi, F., Landi, S., Mohelniková-Duchoňová, B., Vodičková, L., Büchler, M. W., Bugert. P., Vodička, P., Neoptolemos, J. P., Werner, J., Hoheisel, J. D., Bauer, A. S., Giese, N., Canzian, F.: (2013) ABO blood groups and pancreatic cancer risk and survival: Results from the PANcreatic Disease ReseArch (PANDoRA) consortium. Oncol. Rep. 29(4): 1637-1644.

AZV 15-27580A Taste perception, oxidative damage and colon microenvironment in colorectal carcinogenesis: impacts on the disease risk, prognosis and prevention. PI: Dr. Vodička, (2015-2019).

AZV 17-30920A Characterization of acquired chemoresistance by DNA repair gene profiling in colon cancer patients through non-invasive repeated analysis. PI: Ing. Vymetálková, (2017-2020).

GACR 17 – 16857S Identification and comparison of plasma/stool miRNA signature in colorectal cancer by next generation sequencing. PI: Dr. Naccarati, (2017 – 2019).

GACR 18- 09709S  Mapping the traits involved in malignant transformation of colorectal adenoma into carcinoma. PI: Dr. Vodička, (2018-2020).

NV 18-03-00199 Identification of diagnostic markers in colorectal cancer by profiling of trascriptome, DNA methylome and microbiome in adenoma-carcinoma transition. PI: Dr. Vodička, (2018-2021).

GACR 19-10543S Changes in DNA repair system associated with therapy outcome of ovarian carcinoma. PI: Dr. Vodička, (2019-2021).

NV19-09-00237 The clinicopathological and molecular factors detected in metastases, predicting of treatment response in colon cancer patients. PI: Dr.Vymetálková, (2019-2022).

Thomayer hospital Prague

IKEM, Prague

General teaching hospital, Prague

Teaching hospital Pilsen, Pilsen

Teaching hospital Kralovske Vinohrady, Prague

Masaryk University, Brno

First Medical Faculty, Charles University, Prague

Third Medical Faculty, Charles University, Prague

Biomedical Centre, Faculty of Medicine, Pilsen, Charles University, Prague

National Institute of Public Health, Prague

Institute of Biotechnology, CAS v.v.i., Vestec

Institute of Molecular Genetics, ASCR, Prague

Institute of Microbiology, ASCR, Prague

CEITEC - central european institute of technology, Brno

DKFZ (German Cancer Research Center) Heidelberg, Germany (prof. Hemminki, prof. Kumar, Dr. Canzian, Dr. Főrsti)

University of Pisa, Italy (prof. Landi, prof. Barale, dr. Campa)

Italian Institute for Genomic Medicine, Torino, Italy (Dr. Naccarati, Dr. Pardini)

Leiden University Medical Center, Leiden, Holland (prof. Van Wezel)

IDIBAPS / CIBERehd / Hospital Clínic, Barcelona, Spain (Dr. Castellvi-Bel)

Umeå University, Sweden (Prof. Torbjőrn Nilsson)

Vienna Medical University, Austria (prof. Knasműller, Dr.Gsur)

RCSI Royal College of Surgeons in Ireland, Ireland (Dr. Hughes)

Genetics and Epidemiology of Colorectal cancer Consortium (GECCO)

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Contacts

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