13. 01. 2026
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A new co-authored study by scientists from the Department of Auditory Neuroscience, with first author neuroscientist Jana Svobodová Burianová, has been published in the prestigious international journal Hearing Research (open in a new window). The study was created in collaboration with colleagues from the Institute of Physiology of the CAS, specifically from the Laboratory of Neurophysiology of Memory, within the NPO NEUR-IN project. The importance of the study is underscored by the fact that a microscopic image from the publication was selected as the cover image for the journal’s current issue.
The study focuses on how Alzheimer’s disease affects sound processing in the brain in the APP/PS1 mouse model. The authors show that 10-month-old mice have unchanged hearing thresholds but impaired ability to respond adequately to sound stimuli. This manifests itself in weakened sensorimotor gating. These functional changes are accompanied by significant structural changes in neurons in the auditory centres of the brain and in the hippocampus. The results thus suggest that early auditory dysfunction in Alzheimer’s disease primarily has a central, structural basis and could serve as a potential early indicator of the disease.
