Department of Molecular Biology of Cancer
Pavel Vodička, MD, PhD
DNA damage and repair in carcinogenesis of solid tumors
Pavel Vodička, MD, PhD / Soňa Vodenková, PhD
Genome instability represents one of the leading forces driving the onset and development of cancer. It arises as a consequence of the combined effect of DNA damage and errors made by the DNA repair system. In many cancers, DNA damage tolerance and DNA repair pathways are disrupted or deregulated, which increases mutagenesis and genome instability, thereby promoting cancer progression. DNA repair also appears to play a substantial role in cancer therapy response. This project will be performed in response to several unclear and unresolved issues of the role of DNA damage and DNA repair in cancer pathogenesis. The aim of the project will be searching for potential novel biomarkers and confirmation of the validity of already existing biomarkers related to DNA damage and DNA repair, which may be associated with cancer susceptibility and the patient's clinical outcome. The biological basis of different biomarkers and their associations will be also explored. Experimental work will include advanced molecular, cytogenetic, and microscopic techniques on human (cancer) samples and cancer cell lines.
A successful candidate should:
- have a master's degree in molecular/cellular biology, (bio)chemistry, genetics, or medicine;
- have a strong interest in conducting basic cancer research, enthusiasm and high motivation to learn new laboratory techniques, and a commitment to hard work;
- have a good knowledge of and experience in molecular biology of cancer;
- be willing to work with human (tumor) samples and cancer cell lines;
- be able to work independently as well as in a team;
- have good communications skills and the ability to work on an international level;
- have a good working knowledge of the English language (both spoken and written).
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