Institute of Experimental Medicine CAS

 

About Project

Center of Reconstruction Neuroscience – NEURORECON
CZ.02.1.01/0.0/0.0/15_003/0000419

eu-msmt

The project Center of Reconstruction Neuroscience – NEURORECON encompasses the creation and development of excellent research team headed by prominent foreign scientists, prof. James Fawcett (University of Cambridge), which will deal with R & D in the field of therapeutic methods nervous system. The project builds on existing R & D activities of the Institute of Experimental Medicine ASCR, v.v.i. and in connection with its implementation will strengthen the quality of research at the international level, the acquisition of lack of infrastructures and intensify international cooperation IEM.

The project is financed from the Operational Programme Research and Education (OP VVV), which is a multi-year thematic program sponsored by the Ministry of Education, Youth and Sports, within which it is possible in the programming period 2014-2020 draw on funds from the European Structural and Investment Funds (ESI +).

 

 

News

„Regeneration, plasticity, protection“ (Dr. James Fawcett) – 10.–11. 1. 2017, Prague

Conference Programme

Newsletters

březen 2017

 

Project duration

1. 1. 2017 – 30. 10. 2022

 

Research Team

prof. MUDr. James Fawcett, Ph.D.
doc. RNDr. Pavla Jendelová, Ph.D.
PharmDr. Šárka Kubinová, Ph.D.
Dr. Jessica Kwok, Ph.D.
MUDr. Lucia Machová Urdziková, Ph.D.
Dr. Slaven Erceg, Ph.D.
RNDr. Jiří Růžička, Ph.D.
Mgr. Jana Svobodová Burianová, Ph.D.
Juan Pablo Muňoz-Cobo Belart, Ph.D.
Mgr. Kristýna Kekulová
Mgr. Monika Šeneklová
Mgr. Jana Dubišová
Mgr. Noelia Martinez Varea
Mgr. Klára Hahnová

 

External advisory team

Dr. Elisabeth Bradbury – King's College London
prof. Joost Verhaagen – Netherlands Institute for Neuroscience, Amsterdam
Ing. Miroslava Anděrová, PhD. – ÚEM AV ČR
Doc. MVDr. Daša Čížková, DrSc – Ústav Imunologie, SAV, Bratislava
Dr. Andreas Lakatos – University of Cambridge

 

Publications

2017

  • Foscarin, S., Raha-Chowdhury, R., Fawcett, J., Kwok, J.: (2017) Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory. Aging. 9 (6): 1607-1622.
  • Koseki, H., Donegá, M., Lam, B.Y.H., Petrová, V., van Erp, S., Yeo, G.S.H., Kwok, J., Ffrench-Constant, Ch., Eva, R., Fawcett, J.: (2017) Selective rab11 transport and the intrinsic regenerative ability of CNS axons. eLife. 6: e26956.
  • Yang, S., Hilton, S., Alves, J.N., Saksida, L.M., Bussey, T., Matthews, R.T., Kitagawa, H., Spillantini, M.G., Kwok, J., Fawcett, J.: (2017) Antibody recognizing 4-sulfated chondroitin sulfate proteoglycans restores memory in tauopathy-induced neurodegeneration. Neurobiology of Aging. 59: 197-209.
  • Giulia E. Tyzack, Claire E. Hall, Christopher R. Sibley, Tomasz Cymes, Serhiy Forostyak, Giulia Carlino, Ione Meyer, Giampietro Schiavo, Su-Chun Zhang, George M. Gibbons, Jia Newcombe, Rickie Patani & András Lakatos*A neuroprotective astrocyte st 1 ate is induced by neuronal signal EphB1 but fails in ALS models, Nature Communications, Oct 27;8(1):1164.
  • Lucia Machova Urdzikova L, Ruzicka J,Karova K, Kloudova A, Svobodova B, Amin A, Dubisova J, Schmidt M, Kubinova S,  Jhanwar-Uniyal M, Jendelova P. A green tea polyphenol epigallocatechin-3-gallate enhances neuroregeneration after spinal cord injury by altering levels of inflammatory cytokines, Neuropharmacology, 2017 Nov;126:213-223. doi: 10.1016/j.neuropharm.2017.09.006. https://doi.org/10.1016/j.neuropharm.2017.09.006
  • Jiri Ruzicka, Lucia Machova Urdzikova, Barbora Svobodova, Anubhav G.Amin, Kristyna Karova, Jana Dubisova, Kristyna Zaviskova, Sarka Kubinova, Meic Schmidt,Meena Jhanwar-Uniyal and Pavla Jendelova Combined therapy of Curcumin and Epigallocatechin gallate in an experimental model of spinal cord injury in rats. Neural Regeneration Research (in press)
  • Serhiy Forostyak* & Eva Sykova, Neuroprotective potential of cell-based therapies in ALS: from bench to bedside, Front Neurosci. 2017 Oct 24;11:591. doi: 10.3389/fnins.2017.00591. eCollection 2017
  • Eva R, Koseki H, Kanamarlapudi V, Fawcett JW. EFA6 regulates selective polarised transport and axon regeneration from the axon initial segment. J Cell Sci. 2017 Nov 1;130(21):3663-3675. doi: 10.1242/jcs.207423. Epub 2017 Sep 21.
  • Cheah M, Fawcett JW, Andrews MR. Assessment of Thermal Pain Sensation in Rats and Mice Using the Hargreaves Test. Bio Protoc. 2017 Aug 20;7(16). pii: e2506. doi: 10.21769/BioProtoc.2506.
  • Richter RP, Baranova NS, Day AJ, Kwok JC. Glycosaminoglycans in extracellular matrix organisation: are concepts from soft matter physics key to understanding the formation of perineuronal nets? Curr Opin Struct Biol. 2017 Dec 21;50:65-74. doi: 10.1016/j.sbi.2017.12.002.

2018

  • Nieuwenhuis B, Haenzi B, Andrews MR, Verhaagen J, Fawcett JW. Integrins promote axonal regeneration after injury of the nervous system. Biol Rev CambPhilos Soc. 2018 Feb 15. doi: 10.1111/brv.12398. [Epub ahead of print] PubMed PMID: 29446228.
  • Krupa P, Vackova I, Ruzicka J, Zaviskova K, Dubisova J, Koci Z, Turnovcova K, Urdzikova LM, Kubinova S, Rehak S, Jendelova P. The Effect of Human Mesenchymal Stem Cells Derived from Wharton's Jelly in Spinal Cord Injury Treatment Is Dose-Dependent and Can Be Facilitated by Repeated Application. Int J Mol Sci. 2018 May 17;19(5). pii: E1503. doi: 10.3390/ijms19051503.

 

 

Contacts

Prof. James Fawcett, MD, PhD.

Assoc. Prof. Pavla Jendelová, PhD.

Jan Tomanec, MSc

Zuzana Kodymová, MSc

Markéta Nováčková, MSc

Centrum rekonstrukčních neurověd

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Contacts

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