Postdoc position – Corticospinal tract regeneration

Postdoc position – Corticospinal tract regeneration

Postdoc position – Corticospinal tract regeneration

Regeneration of axons in the damaged spinal cord has been a central aim of neuroscience for many decades. Long-distance axon regeneration with accurate connections is the only way to bring back substantial function after spinal cord injury. In the past year Prof Fawcett and his group in Cambridge has demonstrated a method for long distance regeneration (from forelimb levels to brain) of sensory axons in the spinal cord, with correct connections and excellent functional recovery. This method depends on expressing an integrin that recognises tenascin-C that is present in the spinal cord matrix with kindlin-1 to overcome inactivation by inhibitory molecules. The aim of this project is to apply this concept, in collaboration with Cambridge University, to descending motor connections in the corticospinal tract in a more complex way. This approach will include methods to overcome selective exclusion of integrins from the selective transport in mature cortical axons.


Requirements
The successful applicant should have a Ph.D. and/or education in biology or medical science and have a good proficiency in English. Experience with animal work and surgery and molecular biology techniques is advantageous. The successful applicant will also have excellent interpersonal, communication and organizational skills and be highly-motivated with the ability to work independently and as part of the international team of NeuroRecon Centre.


Terms and place of employment
This position is available at the Institute of Experimental Medicine of the ASCR, v.v.i.) in Prague, Czech Republic. The successful candidates will be part of the EU funded Centre of Reconstructive Neuroscience (NeuroRecon) research program. The Centre hosts an international collaborative research program between Institute of Experimental Medicine (Prague, CR) - John van Geest Centre for Brain Repair (University of Cambridge) - Faculty of Biological Sciences (University of Leeds). The position is available immediately as an initial fixed-term contract, with longer-term extension possible upon demonstrated proficiency.


Application
Interested candidates should provide motivation letter, CV and contacts to at least two independent professionals who can provide reference.

Your application must be submitted electronically to Dr. Pavla Jendelova (jendel@biomed.cas.cz). Dr Jendelova will provide additional information about the position as well.